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Protein Page:
RPL15 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RPL15 a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]
Protein type: Translation; Ribosomal protein
Cellular Component: ribosome; nucleus; cytosol
Molecular Function: protein binding; structural constituent of ribosome; RNA binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; viral reproduction; translation; viral infectious cycle; translational termination; mRNA metabolic process; cellular protein metabolic process; translational elongation; RNA metabolic process; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; viral transcription
Reference #:  P61313 (UniProtKB)
Alt. Names/Synonyms: 60S ribosomal protein L15; EC45; FLJ26304; MGC88603; ribosomal protein L15; RL15; RPL10; RPL15; RPLY10; RPYL10
Gene Symbols: RPL15
Molecular weight: 24,146 Da
Basal Isoelectric point: 11.62  Predict pI for various phosphorylation states
Select Structure to View Below

RPL15

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 S34-p CWQYRQLsALHRAPR
0 5 K47-ub PRPTRPDkARRLGYk
0 1 K54-ub kARRLGYkAkQGyVI
0 4 K56-ub RRLGYkAkQGyVIyR
0 20 Y59-p GYkAkQGyVIyRIRV
0 1 Y62-p AkQGyVIyRIRVRRG
0 1 K77 GRKRPVPKGATyGkP
0 25 Y81-p PVPKGATyGkPVHHG
0 1 K83-ac PKGATyGkPVHHGVN
0 36 K83-ub PKGATyGkPVHHGVN
0 1 K93-ub HHGVNQLkFARsLQs
0 11 S97-p NQLkFARsLQsVAEE
0 4 S100-p kFARsLQsVAEERAG
0 96 K140-ub ILIDPFHkAIRRNPD
0 1 T148 AIRRNPDTQWITkPV
0 1 T152 NPDTQWITkPVHkHR
0 44 K153-ub PDTQWITkPVHkHRE
0 17 K157-ub WITkPVHkHREMRGL
0 7 K179-ub RGLGKGHkFHHTIGG
0 29 T197-p AAWRRRNtLQLHRYR
  mouse

 
S34-p CWQYRQLsALHRAPR
K47-ub PRPTRPDkARRLGYK
K54 kARRLGYKAkQGyVI
K56-ub RRLGYKAkQGyVIYR
Y59-p GYKAkQGyVIYRIRV
Y62 AkQGyVIYRIRVRRG
K77-ub GRKRPVPkGATyGkP
Y81-p PVPkGATyGkPVHHG
K83 PkGATyGKPVHHGVN
K83-ub PkGATyGkPVHHGVN
K93 HHGVNQLKFARsLQs
S97-p NQLKFARsLQsVAEE
S100-p KFARsLQsVAEERAG
K140-ub ILIDPFHkAIRRNPD
T148-p AIRRNPDtQWItkPV
T152-p NPDtQWItkPVHkHR
K153-ub PDtQWItkPVHkHRE
K157-ub WItkPVHkHREMRGL
K179-ub RGLGKGHkFHHTIGG
T197-p AAWRRRNtLQLHRYR
  rat

 
S34-p CWQYRQLsALHRAPR
K47 PRPTRPDKARRLGYK
K54 KARRLGYKAKQGYVI
K56 RRLGYKAKQGYVIYR
Y59 GYKAKQGYVIYRIRV
Y62 AKQGYVIYRIRVRRG
K77 GRKRPVPKGATyGKP
Y81-p PVPKGATyGKPVHHG
K83 PKGATyGKPVHHGVN
K83 PKGATyGKPVHHGVN
K93 HHGVNQLKFARsLQS
S97-p NQLKFARsLQSVAEE
S100 KFARsLQSVAEERAG
K140 ILIDPFHKAIRRNPD
T148 AIRRNPDTQWITKPV
T152 NPDTQWITKPVHKHR
K153 PDTQWITKPVHKHRE
K157 WITKPVHKHREMRGL
K179 RGLGKGHKFHHTIGG
T197 AAWRRRNTLQLHRYR
  dog

 
S34 CWQYRQLSALHRAPR
K47 PRPTRPDKARRLGYK
K54 KARRLGYKAKQGYVI
K56 RRLGYKAKQGYVIYR
Y59 GYKAKQGYVIYRIRV
Y62 AKQGYVIYRIRVRRG
K77 GRKRPVPKGATYGKP
Y81 PVPKGATYGKPVHHG
K83 PKGATYGKPVHHGVN
K83 PKGATYGKPVHHGVN
K93 HHGVNQLKFARSLQS
S97 NQLKFARSLQSVAEE
S100 KFARSLQSVAEERAG
K140 ILIDPFHKAIRRNPD
T148 AIRRNPDTQWITKPV
T152 NPDTQWITKPVHKHR
K153 PDTQWITKPVHKHRE
K157 WITKPVHKHREMRGL
K179 RGLGKGHKFHHTIGG
T197 AAWRRRNTLQLHRYR
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