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Protein Page:
PLXNA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLXNA1 Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: cytoplasm; integral to membrane; plasma membrane; nucleus
Molecular Function: semaphorin receptor activity; receptor activity
Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
Reference #:  Q9UIW2 (UniProtKB)
Alt. Names/Synonyms: DKFZp761P19121; NOV; NOVP; plexin 1; plexin A1; Plexin-A1; PLXA1; PLXN1; PLXNA1; Semaphorin receptor NOV
Gene Symbols: PLXNA1
Molecular weight: 211,067 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLXNA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y122 NKLLLLDYAANRLLA
0 1 T446 AYDYRGRTVVFAGTR
0 1 S454 VVFAGTRSGRIRKIL
0 1 T726-ga VGVVKPItLAARNLP
0 1 K1041-ub QLTNPEVkYNYTEDP
0 1 Y1097-p RENGCLVyNDTTMVC
0 1 K1353 EVQANVEKSLTLFGQ
0 1 T1356 ANVEKSLTLFGQLLT
0 1 T1363 TLFGQLLTKKHFLLT
0 1 Y1403-p ALQGEMEyATGVLKQ
0 2 K1418-ub LLSDLIEkNLESKNH
0 1 K1454-ac FLLYKFLkECAGEPL
0 1 Y1486-p AITGEARySLSEDKL
0 1 Y1500-p LIRQQIDyKTLTLNC
0 1 S1597-p YQVTDGSsVALVPKQ
0 57 Y1608-p VPKQTSAyNISNSSt
0 1 T1615-p yNISNSStFTKsLsR
0 1 K1618 SNSStFTKsLsRyEs
0 1 S1619-p NSStFTKsLsRyEsM
0 2 S1621-p StFTKsLsRyEsMLR
0 1 Y1623-p FTKsLsRyEsMLRTA
0 4 S1625-p KsLsRyEsMLRTAss
0 3 S1631-p EsMLRTAssPDsLRS
0 2 S1632-p sMLRTAssPDsLRSR
0 8 S1635-p RTAssPDsLRSRTPM
0 1 T1644 RSRTPMITPDLESGT
0 1 Y1817-p KSWVERYyADIAKMP
0 1 S1844 EQSRLHLSQFNSMSA
  mouse

 
Y120-p NKLLLLDyAANRLLA
T444-p AYDYQGRtVVFAGTR
S452-p VVFAGTRsGRIRKIL
T724 VGVVKPITLAARNLP
K1039 QLSNPEVKYNYTEDP
Y1095 RENSCMVYNDTTMVC
K1351-ub EVQANVEkSLtLFGQ
T1354-p ANVEkSLtLFGQLLt
T1361-p tLFGQLLtKKHFLLT
Y1401 ALQGEMEYATGVLKQ
K1416-ub LLSDLIEkNLESKNH
K1452 FLLYKFLKECAGEPL
Y1484 AITGEARYSLSEDKL
Y1498 LIRQQIDYKTLTLNC
S1595 YQVTDGSSVALVPKQ
Y1606 VPKQTSAYNISNSST
T1613 YNISNSSTFTkSLsR
K1616-ub SNSSTFTkSLsRYEs
S1617 NSSTFTkSLsRYEsM
S1619-p STFTkSLsRYEsMLR
Y1621 FTkSLsRYEsMLRTA
S1623-p kSLsRYEsMLRTAss
S1629-p EsMLRTAssPDsLRS
S1630-p sMLRTAssPDsLRSR
S1633-p RTAssPDsLRSRTPM
T1642-p RSRTPMItPDLESGT
Y1815 KSWVERYYADIAKMP
S1842-p EQSRLHLsQFNSMSA
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