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H2A.4 (human)

Overview H2A.4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleosome; nucleus Molecular Function: DNA binding; protein heterodimerization activity Biological Process: nucleosome assembly Reference #:  Q96QV6 (UniProtKB) Alt. Names/Synonyms: bA317E16.2; H2A histone family, member R; H2A1A; H2AFR; HIST1H2AA; histone 1, H2aa; histone cluster 1, H2aa; Histone H2A type 1-A; Histone H2A/r Gene Symbols: HIST1H2AA Molecular weight: 14,234 Da Basal Isoelectric point: 10.86  Predict pI for various phosphorylation states

Select Structure to View Below H2A.4 1EQZ - A/E=1-128 (chicken) 1HIO - A=15-109 (chicken) 1HQ3 - A/E=1-128 (chicken) 1TZY - A/E=0-128 (chicken) 2ARO - A/E=0-128 (chicken) 2HIO - A=1-128 (chicken) 2XQL - A/C/I/G/E=16-106 (chicken) 3C9K - A/E=2-129 (chicken)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	82		K6-a	__MSGRGkQGGkARA
0	81		K10-a	GRGkQGGkARAKSKS
0	13		K37-u	RIHRLLRkGNYAERI
0	32		K96-u	RNDEELNkLLGGVtI
0	6		T102-p	NkLLGGVtIAQGGVL
0	16		K119-a	IQAVLLPkkTESHHH
0	149		K119-u	IQAVLLPkkTESHHH
0	13		K120-a	QAVLLPkkTESHHHk
0	131		K120-u	QAVLLPkkTESHHHk
0	1		K127-a	kTESHHHkAQSK___
0	9		K127	kTESHHHKAQSK___

	mouse
K6	__MSGPTKRGGKARA
K10	GPTKRGGKARAKVKS
Q37	RVHRLLRQGNYAQRI
K96-u	RNDEELNkLLGRVtI
T102-p	NkLLGRVtIAQGGVL
K119-a	IQAVLLPkkTESHkS
K119-u	IQAVLLPkkTESHkS
K120-a	QAVLLPkkTESHkSQ
K120-u	QAVLLPkkTESHkSQ
K125	PkkTESHKSQTK___
K125-u	PkkTESHkSQTK___

	rat
K6	__MSGRAKQGGKARA
K10	GRAKQGGKARAKAKS
Q37	RVHRLLRQGNYAERI
K96	RNDEELNKLLGRVTI
T102	NKLLGRVTIAQGGVL
K119	IQAVLLPKKTESHHK
K119-u	IQAVLLPkKTESHHK
K120	QAVLLPkKTESHHKS
K120	QAVLLPkKTESHHKS
K126	kKTESHHKSQTK___
K126	kKTESHHKSQTK___

	chicken
K6-a	__MSGRGkQGGKARA
K10	GRGkQGGKARAKAKS
K37	RVHRLLRKGNYAERV
K96	RNDEELNKLLGKVTI
T102	NKLLGKVTIAQGGVL
K119	IQAVLLPKKTDSHKA
K119	IQAVLLPKKTDSHKA
K120	QAVLLPKKTDSHKAK
K120	QAVLLPKKTDSHKAK
K125	PKKTDSHKAKAK___
K125	PKKTDSHKAKAK___

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