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Protein Page:
H2A.4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
H2A.4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component: nucleosome; nucleus
Molecular Function: DNA binding; protein heterodimerization activity
Biological Process: nucleosome assembly
Reference #:  Q96QV6 (UniProtKB)
Alt. Names/Synonyms: bA317E16.2; H2A histone family, member R; H2A1A; H2AFR; HIST1H2AA; histone 1, H2aa; histone cluster 1, H2aa; Histone H2A type 1-A; Histone H2A/r
Gene Symbols: HIST1H2AA
Molecular weight: 14,234 Da
Basal Isoelectric point: 10.86  Predict pI for various phosphorylation states
Select Structure to View Below

H2A.4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 82 K6-ac __MSGRGkQGGkARA
0 81 K10-ac GRGkQGGkARAKSKS
0 13 K37-ub RIHRLLRkGNYAERI
0 3 K96 RNDEELNKLLGGVtI
0 32 K96-ub RNDEELNkLLGGVtI
0 8 T102-p NkLLGGVtIAQGGVL
0 16 K119-ac IQAVLLPkkTESHHH
0 149 K119-ub IQAVLLPkkTESHHH
0 13 K120-ac QAVLLPkkTESHHHk
0 131 K120-ub QAVLLPkkTESHHHk
0 1 K127-ac kTESHHHkAQSK___
0 9 K127 kTESHHHKAQSK___
8240 : Ubiquityl-Histone H2A (Lys119) (D27C4) XP(R) Rabbit mAb
  mouse

 
K6 __MSGPTKRGGKARA
K10 GPTKRGGKARAKVKS
Q37 RVHRLLRQGNYAQRI
K96-ac RNDEELNkLLGRVtI
K96-ub RNDEELNkLLGRVtI
T102-p NkLLGRVtIAQGGVL
K119-ac IQAVLLPkkTESHkS
K119-ub IQAVLLPkkTESHkS
K120-ac QAVLLPkkTESHkSQ
K120-ub QAVLLPkkTESHkSQ
K125 PkkTESHKSQTK___
K125-ub PkkTESHkSQTK___
8240 : Ubiquityl-Histone H2A (Lys119) (D27C4) XP(R) Rabbit mAb
  rat

 
K6 __MSGRAKQGGKARA
K10 GRAKQGGKARAKAKS
Q37 RVHRLLRQGNYAERI
K96-ac RNDEELNkLLGRVtI
K96 RNDEELNKLLGRVtI
T102-p NkLLGRVtIAQGGVL
K119 IQAVLLPKKTESHHK
K119-ub IQAVLLPkKTESHHK
K120 QAVLLPkKTESHHKS
K120 QAVLLPkKTESHHKS
K126 kKTESHHKSQTK___
K126 kKTESHHKSQTK___
8240 : Ubiquityl-Histone H2A (Lys119) (D27C4) XP(R) Rabbit mAb
  chicken

 
K6-ac __MSGRGkQGGKARA
K10 GRGkQGGKARAKAKS
K37 RVHRLLRKGNYAERV
K96 RNDEELNKLLGKVTI
K96 RNDEELNKLLGKVTI
T102 NKLLGKVTIAQGGVL
K119 IQAVLLPKKTDSHKA
K119 IQAVLLPKKTDSHKA
K120 QAVLLPKKTDSHKAK
K120 QAVLLPKKTDSHKAK
K125 PKKTDSHKAKAK___
K125 PKKTDSHKAKAK___
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