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Protein Page:
TNFRSF11B (human)

TNFRSF11B Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal. Note: This description may include information from UniProtKB.
Protein type: Secreted; Inhibitor; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region; plasma membrane
Molecular Function: cytokine activity; receptor activity
Biological Process: response to drug; response to magnesium ion; extracellular matrix organization and biogenesis; tumor necrosis factor-mediated signaling pathway; response to estrogen stimulus; negative regulation of odontogenesis of dentine-containing teeth; apoptosis; response to arsenic; signal transduction; negative regulation of bone resorption; skeletal development; response to nutrient
Disease: Paget Disease, Juvenile
Reference #:  O00300 (UniProtKB)
Alt. Names/Synonyms: MGC29565; OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; TR11B; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
Gene Symbols: TNFRSF11B
Molecular weight: 46,026 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 T360-p KTYHFPKtVtQsLKK
0 1 T362-p YHFPKtVtQsLKKTI
0 1 S364-p FPKtVtQsLKKTIRF

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