May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 17q11-q12
Cellular Component: membrane; perinuclear region of cytoplasm; endocytic vesicle; plasma membrane; caveola; flotillin complex; vesicle; endosome; acrosomal membrane
Molecular Function: ionotropic glutamate receptor binding; protein binding
Biological Process: epidermis development; protein stabilization; cell adhesion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.