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FLOT2 (human)

Overview FLOT2 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB. Protein type: Cell adhesion Cellular Component: cell surface; endocytic vesicle; plasma membrane; flotillin complex; endosome; acrosomal membrane Biological Process: epidermis development; cell adhesion Reference #:  Q14254 (UniProtKB) Alt. Names/Synonyms: ECS-1; ECS1; Epidermal surface antigen; ESA; ESA1; FLOT2; flotillin 2; Flotillin 2 (epidermal surface antigen 1); Flotillin-2; M17S1; Membrane component chromosome 17 surface marker 1; membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1) Gene Symbols: FLOT2 Molecular weight: 47,064 Da Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FLOT2 1WIN - A=1-123 (mouse)

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	Sites Implicated In
endocytosis, altered: Y163‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		Y24	GGCCGSDYKQYVFGG
1	0		Y27	CGSDYKQYVFGGWAW
0	7		K81-u	QVKIMTEkELLAVAC
0	21		K100-u	GKNVQDIkNVVLQTL
1	0		Y124	TLTVEQIYQDRDQFA
0	2		Y158-p	SFTIKDVyDkVDyLS
0	2		K160-u	TIKDVyDkVDyLSSL
3	19		Y163-p	DVyDkVDyLSSLGkT
0	2		K169-u	DyLSSLGkTQtAVVQ
0	2		T172-p	SSLGkTQtAVVQRDA
0	28		Y241-p	TAEAQLAyELQGARE
0	3		T285-p	TDKELIAtVRRPAEA
0	3		Y348-p	MKLKAEAyQKyGDAA
0	1		K350	LKAEAyQKyGDAAKM
0	4		Y351-p	KAEAyQKyGDAAKMA
0	12		K370-u	ALPQIAAkIAAPLTK
0	1		S385-p	VDEIVVLsGDNskVt
0	1		S389-p	VVLsGDNskVtSEVN
0	3		K390-u	VLsGDNskVtSEVNR
0	1		T392-p	sGDNskVtSEVNRLL
0	1		K416	LTGVDLSKIPLIkKA
0	1		K421-u	LSKIPLIkKATGVQV

	mouse
Y24	GGCCGSDYKQYVFGG
Y27	CGSDYKQYVFGGWAW
K81	QVKIMTEKELLAVAC
K100-u	GKNVQDIkNVVLQTL
Y124	TLTVEQIYQDRDQFA
Y158	SFTIKDVYDkVDYLS
K160-u	TIKDVYDkVDYLSSL
Y163	DVYDkVDYLSSLGkT
K169-u	DYLSSLGkTQTAVVQ
T172	SSLGkTQTAVVQRDA
Y241	TAEAQLAYELQGARE
T285	TDKELIATVRRPAEA
Y348	MKLKAEAYQkYGDAA
K350-u	LKAEAYQkYGDAAKM
Y351	KAEAYQkYGDAAKMA
K370-u	ALPQIAAkISAPLTK
S385	VDEIVVLSGDNSkVT
S389	VVLSGDNSkVTSEVN
K390-u	VLSGDNSkVTSEVNR
T392	SGDNSkVTSEVNRLL
K416-u	LTGVDLSkIPLIKNA
K421	LSkIPLIKNATGAQV

	rat
Y24-p	GGCCGSDyKQyVFGG
Y27-p	CGSDyKQyVFGGWAW
K81	QVKIMTEKELLAVAC
K100	GKNVQDIKNVVLQTL
Y124-p	TLTVEQIyQDRDQFA
Y158-p	SFTIKDVyDKVDyLS
K160	TIKDVyDKVDyLSSL
Y163-p	DVyDKVDyLSSLGKT
K169	DyLSSLGKTQTAVVQ
T172	SSLGKTQTAVVQRDA
Y241	TAEAQLAYELQGARE
T285	TDKELIATVRRPAEA
Y348	MKLKAEAYQKYGDAA
K350	LKAEAYQKYGDAAKM
Y351	KAEAYQKYGDAAKMA
K370-u	ALPQIAAkISAPLTK
S385	VDEIVVLSGDNSKVT
S389	VVLSGDNSKVTSEVN
K390	VLSGDNSKVTSEVNR
T392	SGDNSKVTSEVNRLL
K416	LTGVDLSKIPLIKNA
K421	LSKIPLIKNATGAQV

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