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Protein Page:
FLOT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FLOT2 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Cellular Component: perinuclear region of cytoplasm; endocytic vesicle; plasma membrane; caveola; flotillin complex; endosome; vesicle; acrosomal membrane
Molecular Function: ionotropic glutamate receptor binding; protein binding
Biological Process: epidermis development; cell adhesion
Reference #:  Q14254 (UniProtKB)
Alt. Names/Synonyms: ECS-1; ECS1; Epidermal surface antigen; ESA; ESA1; FLOT2; flotillin 2; Flotillin 2 (epidermal surface antigen 1); Flotillin-2; M17S1; Membrane component chromosome 17 surface marker 1; membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
Gene Symbols: FLOT2
Molecular weight: 47,064 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLOT2

Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: Y163‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y24 GGCCGSDYKQYVFGG
1 0 Y27 CGSDYKQYVFGGWAW
0 7 K81-ub QVKIMTEkELLAVAC
0 21 K100-ub GKNVQDIkNVVLQTL
1 0 Y124 TLTVEQIYQDRDQFA
0 1 Y158 SFTIKDVYDkVDyLS
0 2 K160-ub TIKDVYDkVDyLSSL
3 18 Y163-p DVYDkVDyLSSLGkT
0 2 K169-ub DyLSSLGkTQtAVVQ
0 2 T172-p SSLGkTQtAVVQRDA
0 1 S227-p ELQKSAFsEEVNIKT
0 28 Y241-p TAEAQLAyELQGARE
0 3 T285-p TDKELIAtVRRPAEA
0 3 Y348-p MKLKAEAyQKyGDAA
0 1 K350 LKAEAyQKyGDAAKM
0 3 Y351-p KAEAyQKyGDAAKMA
0 12 K370-ub ALPQIAAkIAAPLTK
0 1 S385-p VDEIVVLsGDNskVt
0 1 S389-p VVLsGDNskVtSEVN
0 3 K390-ub VLsGDNskVtSEVNR
0 1 T392-p sGDNskVtSEVNRLL
0 1 K416 LTGVDLSKIPLIkKA
0 1 K421-ub LSKIPLIkKATGVQV
  mouse

 
Y24 GGCCGSDYKQYVFGG
Y27 CGSDYKQYVFGGWAW
K81 QVKIMTEKELLAVAC
K100-ub GKNVQDIkNVVLQTL
Y124 TLTVEQIYQDRDQFA
Y158 SFTIKDVYDkVDYLS
K160-ub TIKDVYDkVDYLSSL
Y163 DVYDkVDYLSSLGkT
K169-ub DYLSSLGkTQTAVVQ
T172 SSLGkTQTAVVQRDA
S227 ELQKSAFSEEVNIKT
Y241 TAEAQLAYELQGARE
T285 TDKELIATVRRPAEA
Y348 MKLKAEAYQkYGDAA
K350-ub LKAEAYQkYGDAAKM
Y351 KAEAYQkYGDAAKMA
K370-ub ALPQIAAkISAPLTK
S385 VDEIVVLSGDNSkVT
S389 VVLSGDNSkVTSEVN
K390-ub VLSGDNSkVTSEVNR
T392 SGDNSkVTSEVNRLL
K416-ub LTGVDLSkIPLIKNA
K421 LSkIPLIKNATGAQV
  rat

 
Y24-p GGCCGSDyKQyVFGG
Y27-p CGSDyKQyVFGGWAW
K81 QVKIMTEKELLAVAC
K100 GKNVQDIKNVVLQTL
Y124-p TLTVEQIyQDRDQFA
Y158-p SFTIKDVyDKVDyLS
K160 TIKDVyDKVDyLSSL
Y163-p DVyDKVDyLSSLGKT
K169 DyLSSLGKTQTAVVQ
T172 SSLGKTQTAVVQRDA
S227 ELQKSAFSEEVNIKT
Y241 TAEAQLAYELQGARE
T285 TDKELIATVRRPAEA
Y348 MKLKAEAYQKYGDAA
K350 LKAEAYQKYGDAAKM
Y351 KAEAYQKYGDAAKMA
K370-ub ALPQIAAkISAPLTK
S385 VDEIVVLSGDNSKVT
S389 VVLSGDNSKVTSEVN
K390 VLSGDNSKVTSEVNR
T392 SGDNSKVTSEVNRLL
K416 LTGVDLSKIPLIKNA
K421 LSKIPLIKNATGAQV
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