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Protein Page:
PR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm; mitochondrial outer membrane
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; enzyme binding; DNA binding; zinc ion binding; steroid hormone receptor activity; steroid binding; receptor binding
Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; signal transduction; ovulation from ovarian follicle; regulation of epithelial cell proliferation
Reference #:  P06401 (UniProtKB)
Alt. Names/Synonyms: NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PRGR; Progesterone receptor
Gene Symbols: PGR
Molecular weight: 98,981 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PR

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S294‑p
cell growth, altered: S294‑p, K388‑sm
transcription, induced: S81‑p, S102‑p, S162‑p, K183‑ac, S190‑p, S294‑p, S345‑p, S400‑p, S676‑p
transcription, inhibited: K388‑sm
intracellular localization: S294‑p
molecular association, regulation: S81‑p, K183‑ac, S345‑p
phosphorylation: K183‑ac
protein degradation: S294‑p
sumoylation: S294‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 K7-sm _MTELKAkGPRAPHV
0 1 S20-p HVAGGPPsPEVGSPL
5 0 S81-p TQDQQSLsDVEGAys
0 1 Y87-p LsDVEGAysRAEATR
0 1 S88-p sDVEGAysRAEATRG
2 1 S102-p GAGGSSSsPPEKDSG
0 1 S130-p GPGQSQPsPPACEVT
5 4 S162-p PATQRVLsPLMSRSG
1 1 K183-ac SGTAAAHkVLPRGLs
0 2 K183-ub SGTAAAHkVLPRGLs
5 1 S190-p kVLPRGLsPARQLLL
1 0 S213-p SGAPVKPsPQAAAVE
1 0 S227 EVEEEDGSESEESAG
0 1 S229 EEEDGSESEESAGPL
0 1 S232 DGSESEESAGPLLKG
1 0 S276 PKEDSRFSAPRVALV
19 0 S294-p APMAPGRsPLATTVM
1 0 S328 RQLLEDESYDGGAGA
6 1 S345-p AFAPPRSsPCASSTP
2 0 K388-ub QPPALKIkEEEEGAE
7 0 K388-sm QPPALKIkEEEEGAE
7 0 S400-p GAEASARsPRSYLVA
0 1 N410 SYLVAGANPAAFPDF
1 0 K464-m1 TLECILYkAEGAPPQ
1 0 K531-sm GYQAAVLkEGLPQVY
1 0 S549-p LNYLRPDsEAsQsPQ
1 0 S552-p LRPDsEAsQsPQYsF
2 0 S554-p PDsEAsQsPQYsFEs
2 0 S558-p AsQsPQYsFEsLPQK
1 0 S561-p sPQYsFEsLPQKICL
2 1 S676-p LSQRFTFsPGQDIQL
3171 : Phospho-Progesterone Receptor (Ser190) Antibody
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
12783 : Phospho-Progesterone Receptor (Ser345) Antibody
  PR iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K19 SGTAAAHKVLPRGLs
K19 SGTAAAHKVLPRGLs
S26-p KVLPRGLsPARQLLL
S49 SGAPVKPSPQAAAVE
S63-p EVEEEDGsESEESAG
S65 EEEDGsESEESAGPL
S68 DGsESEESAGPLLKG
S112-p PKEDSRFsAPRVALV
S130-p APMAPGRsPLATTVM
S164-p RQLLEDEsYDGGAGA
S181 AFAPPRSSPCASSTP
K224 QPPALKIKEEEEGAE
K224 QPPALKIKEEEEGAE
S236-p GAEASARsPRSYLVA
N246 SYLVAGANPAAFPDF
K300 TLECILYKAEGAPPQ
K367 GYQAAVLKEGLPQVY
S385 LNYLRPDSEASQsPQ
S388 LRPDSEASQsPQYsF
S390-p PDSEASQsPQYsFES
S394-p ASQsPQYsFESLPQK
S397 sPQYsFESLPQKICL
S512-p LSQRFTFsPGQDIQL
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
  mouse

 
K7 _MTELQAKDPQVLHT
S20 HTSGASPSPPHIGSP
S82 TGDQQSLSDVEGAFS
- gap
S89 SDVEGAFSGVEATHR
S102 HREGGRNSRPPEKDS
S131 GPEQSHASPPACEAI
S163 PATKGLLSPLMSRPE
K184 SGTGRGQKVLPKGLS
K184 SGTGRGQKVLPKGLS
S191 KVLPKGLSPPRQLLL
S214 PGAGVKPSPQPAAGE
- gap
T230-p EEDSGLEtEGsASPL
S233-p SGLEtEGsASPLLKS
S277 PKEDSRFSAPRVSLE
S294-p SPIAPGRsPLATTVV
S328 RQLLEGESYDGGATA
S343 GPFCPPRSPSAPSTP
K386 QTPGLKIKEEEEGAD
K386 QTPGLKIKEEEEGAD
S398 GADAAVRSPRPYLSA
S408-p PYLSAGAsSSTFPDF
K459 ALECILYKAEAPPTQ
K521 GYQAAVLKDSLPQVY
S539 LNYLRPDSEASQSPQ
S542 LRPDSEASQSPQYGF
S544 PDSEASQSPQYGFDS
G548 ASQSPQYGFDSLPQK
S551 SPQYGFDSLPQKICL
S666 LSQRITFSPNQEIQL
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
  rat

 
K7 _MTELQAKDPRTLHT
S20 HTSGAAPSPTHVGSP
S82 TQNQQSLSDVEGAFS
- gap
S89 SDVEGAFSGVEASRR
S98 VEASRRRSRNPRAPE
S130 GPEQSQTSPPACEAI
S162 PATKGLLSPLMSRPE
K183 SGTGAGQKVLPKAVS
K183 SGTGAGQKVLPKAVS
S190 KVLPKAVSPPRQLLL
S213 PGAGVKPSQQPATVE
- gap
T229 EEDGGLETEGSAGPL
S232 GGLETEGSAGPLLKS
S276 PKEDSRFSAPRVSLE
S293 APVAPGRSPLATTVV
S327 RQLLEGDSYDGGAAA
S344 PFAPPRGSPSAPSPP
K387 QPPGLKIKEEEEGTE
K387 QPPGLKIKEEEEGTE
S399 GTEAASRSPRPYLLA
S409 PYLLAGASAATFPDF
K458 ALECILYKAEGAPPT
K521 GYQAAVLKDSLPQVY
S539 LNYLRPDSEASQSPQ
S542 LRPDSEASQSPQYGF
S544 PDSEASQSPQYGFDS
G548 ASQSPQYGFDSLPQK
S551 SPQYGFDSLPQKICL
S666 LGQRITFSPNQEIQL
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
  chicken

 
K7 _MTEVKSKETRAPSS
S13 SKETRAPSSARDGAV
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S176 RPGPEDASENRAPGL
- gap
- gap
- gap
- gap
S259 SAFGPRSSPSVPAAD
K294 FQSALKIKEEGVGLP
K294 FQSALKIKEEGVGLP
- gap
- gap
K335 SLECVLYKAEPPLLP
K385 GFPAAVLKEGLPQLC
T403 LGYVRPDTETSQSSQ
S406 VRPDTETSQSSQYSF
S408 PDTETSQSSQYSFES
S412 TSQSSQYSFESLPQK
S415 SSQYSFESLPQKICL
S529 LTQRLSFSPNQEIPF
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