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PR (human)

Overview PR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Nuclear receptor Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus Molecular Function: identical protein binding; ligand-dependent nuclear receptor activity; protein binding; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding; receptor binding Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; gene expression; signal transduction; ovulation from ovarian follicle; regulation of epithelial cell proliferation Reference #:  P06401 (UniProtKB) Alt. Names/Synonyms: NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRGR; Progesterone receptor Gene Symbols: PGR Molecular weight: 98,981 Da Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PR 1A28 - A/B=678-933 (human) 1E3K - A/B=676-933 (human) 1SQN - A/B=673-933 (human) 1SR7 - A/B=676-933 (human) 1ZUC - A/B=676-933 (human) 2C7A - A/B=563-640 (human) 2OVH - A=678-933 (human) 2OVM - A=678-933 (human) 2W8Y - A/B=678-933 (human) 3D90 - A/B=676-933 (human) 3G8N - A/B=673-933 (human) 3G8O - A/B=673-933 (human) 3HQ5 - A/B=678-933 (human) 3KBA - A/B=681-933 (human) 3ZR7 - A/B=678-933 (human) 3ZRA - A/B=678-933 (human) 3ZRB - A/B=678-933 (human) 4A2J - A/B=514-769 (human) 4APU - A/B=514-769 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8N 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU  |  Phospho3D  |  DISEASE 264080 607311  |  Source  |  NURSA  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: S294‑p cell growth, altered: S294‑p, K388‑s transcription, altered: S81‑p, S102‑p, S162‑p, S190‑p, S294‑p, S345‑p, K388‑s, S400‑p, S676‑p intracellular localization: S294‑p molecular association, regulation: S345‑p protein degradation: S294‑p sumoylation: S294‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		K7-s	_MTELKAkGPRAPHV
0	1		S20-p	HVAGGPPsPEVGSPL
4	0		S81-p	TQDQQSLsDVEGAys
0	1		Y87-p	LsDVEGAysRAEATR
0	1		S88-p	sDVEGAysRAEATRG
2	1		S102-p	GAGGSSSsPPEKDSG
0	1		S130-p	GPGQSQPsPPACEVT
5	3		S162-p	PATQRVLsPLMSRSG
0	2		K183-u	SGTAAAHkVLPRGLs
4	1		S190-p	kVLPRGLsPARQLLL
1	0		S213-p	SGAPVKPsPQAAAVE
0	1		S229	EEEDGSESEESAGPL
0	1		S232	DGSESEESAGPLLKG
16	0		S294-p	APMAPGRsPLATTVM
5	1		S345-p	AFAPPRSsPCASSTP
2	0		K388-u	QPPALKIkEEEEGAE
7	0		K388-s	QPPALKIkEEEEGAE
5	0		S400-p	GAEASARsPRSYLVA
0	1		N410	SYLVAGANPAAFPDF
1	0		K531-s	GYQAAVLkEGLPQVY
1	0		S549-p	LNYLRPDsEAsQsPQ
1	0		S552-p	LRPDsEAsQsPQYsF
1	0		S554-p	PDsEAsQsPQYsFEs
1	0		S558-p	AsQsPQYsFEsLPQK
1	0		S561-p	sPQYsFEsLPQKICL
1	1		S676-p	LSQRFTFsPGQDIQL

	PR iso2
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K19	SGTAAAHKVLPRGLS
S26	KVLPRGLSPARQLLL
S49	SGAPVKPSPQAAAVE
S65	EEEDGSESEESAGPL
S68	DGSESEESAGPLLKG
S130	APMAPGRSPLATTVM
S181	AFAPPRSSPCASSTP
K224	QPPALKIKEEEEGAE
K224	QPPALKIKEEEEGAE
S236	GAEASARSPRSYLVA
N246	SYLVAGANPAAFPDF
K367	GYQAAVLKEGLPQVY
S385	LNYLRPDSEASQSPQ
S388	LRPDSEASQSPQYSF
S390	PDSEASQSPQYSFES
S394	ASQSPQYSFESLPQK
S397	SPQYSFESLPQKICL
S512	LSQRFTFSPGQDIQL

	mouse
K7	_MTELQAKDPQVLHT
S20	HTSGASPSPPHIGSP
S82	TGDQQSLSDVEGAFS
F88	LSDVEGAFSGVEATH
S89	SDVEGAFSGVEATHR
-	gap
S131	GPEQSHASPPACEAI
S163	PATKGLLSPLMSRPE
K184	SGTGRGQKVLPKGLS
S191	KVLPKGLSPPRQLLL
S214	PGAGVKPSPQPAAGE
T230-p	EEDSGLEtEGsASPL
S233-p	SGLEtEGsASPLLKS
S294-p	SPIAPGRsPLATTVV
-	gap
K386	QTPGLKIKEEEEGAD
K386	QTPGLKIKEEEEGAD
S398	GADAAVRSPRPYLSA
S408-p	PYLSAGAsSSTFPDF
K521	GYQAAVLKDSLPQVY
S539	LNYLRPDSEASQSPQ
S542	LRPDSEASQSPQYGF
S544	PDSEASQSPQYGFDS
G548	ASQSPQYGFDSLPQK
S551	SPQYGFDSLPQKICL
S666	LSQRITFSPNQEIQL

	rat
K7	_MTELQAKDPRTLHT
S20	HTSGAAPSPTHVGSP
S82	TQNQQSLSDVEGAFS
F88	LSDVEGAFSGVEASR
S89	SDVEGAFSGVEASRR
-	gap
S130	GPEQSQTSPPACEAI
S162	PATKGLLSPLMSRPE
K183	SGTGAGQKVLPKAVS
S190	KVLPKAVSPPRQLLL
S213	PGAGVKPSQQPATVE
T229	EEDGGLETEGSAGPL
S232	GGLETEGSAGPLLKS
S293	APVAPGRSPLATTVV
S344	PFAPPRGSPSAPSPP
K387	QPPGLKIKEEEEGTE
K387	QPPGLKIKEEEEGTE
S399	GTEAASRSPRPYLLA
S409	PYLLAGASAATFPDF
K521	GYQAAVLKDSLPQVY
S539	LNYLRPDSEASQSPQ
S542	LRPDSEASQSPQYGF
S544	PDSEASQSPQYGFDS
G548	ASQSPQYGFDSLPQK
S551	SPQYGFDSLPQKICL
S666	LGQRITFSPNQEIQL

	chicken
K7	_MTEVKSKETRAPSS
S13	SKETRAPSSARDGAV
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S176	RPGPEDASENRAPGL
-	gap
G219	AAVEPGAGQDYLHVP
S259	SAFGPRSSPSVPAAD
K294	FQSALKIKEEGVGLP
K294	FQSALKIKEEGVGLP
-	gap
A313	PFLGAKAAPADFAQP
K385	GFPAAVLKEGLPQLC
T403	LGYVRPDTETSQSSQ
S406	VRPDTETSQSSQYSF
S408	PDTETSQSSQYSFES
S412	TSQSSQYSFESLPQK
S415	SSQYSFESLPQKICL
S529	LTQRLSFSPNQEIPF

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