a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm; cytosol; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: negative regulation of smooth muscle cell proliferation; heart development; positive regulation of transcription, DNA-dependent; low-density lipoprotein receptor biosynthetic process; cell maturation; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; response to lipid; signal transduction; response to caffeine; response to vitamin A; epithelial cell differentiation; regulation of blood pressure; positive regulation of oligodendrocyte differentiation; response to nutrient; placenta development; long-chain fatty acid transport; caspase activation; response to drug; transcription initiation from RNA polymerase II promoter; organ regeneration; cell fate commitment; response to retinoic acid; monocyte differentiation; negative regulation of acute inflammatory response; G-protein coupled receptor protein signaling pathway; negative regulation of telomerase activity; cellular response to insulin stimulus; lipoprotein transport; response to estrogen stimulus; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; brown fat cell differentiation; positive regulation of fat cell differentiation; innate immune response; steroid hormone mediated signaling; positive regulation of transcription factor activity; fatty acid oxidation; positive regulation of transcription from RNA polymerase II promoter; gene expression; lipid metabolic process; response to cold; negative regulation of cell growth; negative regulation of transcription, DNA-dependent
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.