a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: nucleoplasm; cytosol; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; heart development; low-density lipoprotein receptor biosynthetic process; cell maturation; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; response to lipid; glucose homeostasis; signal transduction; response to vitamin A; response to caffeine; epithelial cell differentiation; regulation of blood pressure; positive regulation of oligodendrocyte differentiation; response to nutrient; placenta development; caspase activation; response to drug; long-chain fatty acid transport; transcription initiation from RNA polymerase II promoter; organ regeneration; cell fate commitment; response to retinoic acid; monocyte differentiation; negative regulation of acute inflammatory response; G-protein coupled receptor protein signaling pathway; negative regulation of telomerase activity; cellular response to insulin stimulus; lipoprotein transport; response to estrogen stimulus; response to low density lipoprotein stimulus; positive regulation of fatty acid oxidation; white fat cell differentiation; brown fat cell differentiation; innate immune response; positive regulation of fat cell differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; fatty acid oxidation; negative regulation of cell growth; lipid metabolic process; response to cold; negative regulation of transcription, DNA-dependent
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.