a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: nucleoplasm; nucleus; cytosol
Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: negative regulation of smooth muscle cell proliferation; heart development; positive regulation of transcription, DNA-dependent; cell maturation; low-density lipoprotein receptor biosynthetic process; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; response to lipid; glucose homeostasis; signal transduction; response to vitamin A; response to caffeine; epithelial cell differentiation; regulation of blood pressure; positive regulation of oligodendrocyte differentiation; response to nutrient; placenta development; caspase activation; long-chain fatty acid transport; response to drug; transcription initiation from RNA polymerase II promoter; organ regeneration; cell fate commitment; response to retinoic acid; monocyte differentiation; negative regulation of acute inflammatory response; negative regulation of telomerase activity; G-protein coupled receptor protein signaling pathway; cellular response to insulin stimulus; lipoprotein transport; response to estrogen stimulus; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; brown fat cell differentiation; innate immune response; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; fatty acid oxidation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; response to cold; negative regulation of cell growth; lipid metabolic process; negative regulation of transcription, DNA-dependent
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.