a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm; nucleus; cytosol
Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; arachidonic acid binding; retinoid X receptor binding; protein binding; enzyme binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: negative regulation of smooth muscle cell proliferation; heart development; positive regulation of transcription, DNA-dependent; low-density lipoprotein receptor biosynthetic process; cell maturation; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; response to lipid; signal transduction; glucose homeostasis; response to vitamin A; response to caffeine; epithelial cell differentiation; regulation of blood pressure; positive regulation of oligodendrocyte differentiation; response to nutrient; placenta development; response to drug; caspase activation; long-chain fatty acid transport; transcription initiation from RNA polymerase II promoter; organ regeneration; response to retinoic acid; cell fate commitment; monocyte differentiation; negative regulation of acute inflammatory response; negative regulation of telomerase activity; G-protein coupled receptor protein signaling pathway; cellular response to insulin stimulus; response to estrogen stimulus; lipoprotein transport; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; brown fat cell differentiation; innate immune response; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; fatty acid oxidation; steroid hormone mediated signaling; gene expression; positive regulation of transcription factor activity; negative regulation of cell growth; response to cold; lipid metabolic process; negative regulation of transcription, DNA-dependent
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.