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PPAR-gamma (human)

Overview PPAR-gamma a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor; DNA binding protein Cellular Component: nucleoplasm; nucleus; cytosol Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; chromatin binding; transcription factor activity Biological Process: negative regulation of smooth muscle cell proliferation; heart development; positive regulation of transcription, DNA-dependent; low-density lipoprotein receptor biosynthetic process; cell maturation; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; signal transduction; response to lipid; response to caffeine; epithelial cell differentiation; regulation of blood pressure; positive regulation of oligodendrocyte differentiation; response to nutrient; placenta development; caspase activation; response to drug; long-chain fatty acid transport; transcription initiation from RNA polymerase II promoter; organ regeneration; cell fate commitment; response to retinoic acid; monocyte differentiation; negative regulation of acute inflammatory response; negative regulation of telomerase activity; cellular response to insulin stimulus; response to estrogen stimulus; lipoprotein transport; response to low density lipoprotein stimulus; induction of apoptosis; positive regulation of fatty acid oxidation; white fat cell differentiation; brown fat cell differentiation; positive regulation of fat cell differentiation; innate immune response; fatty acid oxidation; positive regulation of transcription from RNA polymerase II promoter; gene expression; positive regulation of transcription factor activity; negative regulation of cell growth; lipid metabolic process; response to cold; negative regulation of transcription, DNA-dependent Reference #:  P37231 (UniProtKB) Alt. Names/Synonyms: CIMT1; GLM1; NR1C3; Nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor gamma; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma 1; PPAR gamma; PPAR-gamma; PPARG; PPARG1; PPARG2; PPARgamma Gene Symbols: PPARG Molecular weight: 57,620 Da Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  mTOR Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPAR-gamma 1FM6 - D/X=234-505 (human) 1FM9 - D=234-505 (human) 1I7I - A/B=225-505 (human) 1K74 - D=234-505 (human) 1KNU - A/B=232-505 (human) 1NYX - A/B=230-505 (human) 1PRG - A/B=235-504 (human) 1RDT - D=235-505 (human) 1WM0 - X=232-505 (human) 1ZEO - A/B=231-505 (human) 1ZGY - A=234-505 (human) 2ATH - A/B=235-505 (human) 2F4B - A/B=235-505 (human) 2FVJ - A=235-505 (human) 2G0G - A/B=235-505 (human) 2G0H - A/B=235-505 (human) 2GTK - A=235-505 (human) 2HFP - A=234-505 (human) 2HWQ - A/B=235-505 (human) 2HWR - A/B=235-505 (human) 2I4J - A/B=222-504 (human) 2I4P - A/B=222-504 (human) 2I4Z - A/B=222-504 (human) 2OM9 - A/B/C/D=232-505 (human) 2P4Y - A/B=231-505 (human) 2POB - A/B=234-505 (human) 2PRG - A/B=235-505 (human) 2Q59 - A/B=233-505 (human) 2Q5P - A/B=233-505 (human) 2Q5S - A/B=233-505 (human) 2Q61 - A/B=233-505 (human) 2Q6R - A/B=233-505 (human) 2Q6S - A/B=233-505 (human) 2Q8S - A/B=235-505 (human) 2QMV - A=235-504 (human) 2VSR - A/B=202-475 (human) 2VST - A/B=202-475 (human) 2VV0 - A/B=202-475 (human) 2VV1 - A/B=202-475 (human) 2VV2 - A/B=202-475 (human) 2VV3 - A/B=202-475 (human) 2VV4 - A/B=202-475 (human) 2XKW - A/B=204-477 (human) 2YFE - A/B=195-477 (human) 2ZK0 - A/B=223-504 (human) 2ZK1 - A/B=223-504 (human) 2ZK2 - A/B=223-504 (human) 2ZK3 - A/B=223-504 (human) 2ZK4 - A/B=223-504 (human) 2ZK5 - A/B=223-504 (human) 2ZK6 - A/B=223-504 (human) 2ZNO - A/B=223-504 (human) 2ZVT - A/B=223-504 (human) 3ADS - A/B=223-505 (human) 3ADT - A/B=223-505 (human) 3ADU - A/B=223-505 (human) 3ADV - A/B=223-505 (human) 3ADW - A/B=223-505 (human) 3ADX - A/B=223-505 (human) 3AN3 - A/B=223-504 (human) 3AN4 - A/B=223-504 (human) 3B0Q - A/B=231-504 (human) 3B0R - A/B=231-504 (human) 3B1M - A=234-505 (human) 3B3K - A/B=223-504 (human) 3BC5 - A=231-505 (human) 3CDP - A/B=223-504 (human) 3CDS - A/B=223-504 (human) 3CS8 - A=234-504 (human) 3CWD - A/B=236-505 (human) 3D6D - A/B=223-504 (human) 3DZU - D=102-505 (human) 3DZY - D=102-505 (human) 3E00 - D=102-505 (human) 3ET0 - A/B=235-505 (human) 3ET3 - A=235-505 (human) 3FEJ - A=235-505 (human) 3FUR - A=234-505 (human) 3G9E - A=235-505 (human) 3GBK - A/B=235-505 (human) 3H0A - D=234-505 (human) 3HO0 - A/B=223-504 (human) 3HOD - A/B=223-504 (human) 3IA6 - A/B=235-505 (human) 3K8S - A/B=234-505 (human) 3KMG - A/D=234-505 (human) 3LMP - A=234-505 (human) 3NOA - A/B=235-505 (human) 3OSI - A/B=224-504 (human) 3OSW - A/B=224-504 (human) 3PBA - A/B=224-505 (human) 3PO9 - A/B=224-505 (human) 3PRG - A=232-505 (human) 3QT0 - A=235-505 (human) 3R5N - A=232-505 (human) 3R8A - A/B=235-505 (human) 3R8I - A/B=223-505 (human) 3S9S - A=234-505 (human) 3SZ1 - A/B=232-505 (human) 3T03 - A/B=234-505 (human) 3TY0 - A/B=231-505 (human) 3U9Q - A=236-504 (human) 3V9T - A=234-505 (human) 3V9V - A=234-505 (human) 3V9Y - A=234-505 (human) 3VJH - A/B=223-504 (human) 3VJI - A/B=223-504 (human) 3VN2 - A=225-505 (human) 3VSO - A/B=223-504 (human) 3VSP - A/B=223-504 (human) 4A4V - A/B=195-477 (human) 4A4W - A/B=195-477 (human) 4E4K - A/B=223-505 (human) 4E4Q - A/B=223-505 (human) 4EM9 - A/B=235-505 (human) 4EMA - A/B=235-505 (human) 4F9M - C=686-700 (human) 4FGY - B=686-696 (human) 4PRG - A/B/C/D=235-504 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 4A4V 4A4W 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4PRG  |  Phospho3D  |  DISEASE 125853 137800 151660 601487 601665 604367 609338  |  Source  |  NURSA  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell differentiation, altered: S112‑p cell growth, altered: S112‑p transcription, altered: S112‑p protein degradation: S112‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S46	WPTNFGISSVDLSVM
1	0		S51	GISSVDLSVMEDHSH
1	0		K63	HSHSFDIKPFTTVDF
0	1		Y95-p	PVVADYKyDLKLQEy
0	1		Y102-p	yDLKLQEyQSAIkVE
7	0		K107-s	QEyQSAIkVEPAsPP
14	0		S112-p	AIkVEPAsPPYYSEK
0	1		Y173	TIRLKLIYDRCDLNC
1	1		K268	ARAILTGKTTDKsPF
4	1		S273-p	TGKTTDKsPFVIYDM
1	1		K293	GEDKIKFKHITPLQE
0	1		S317	FQGCQFRSVEAVQEI
1	0		K395	FGDFMEPKFEFAVKF

	mouse ► Hide Isoforms
S46	WPTNFGISSVDLSVM
S51	GISSVDLSVMEDHSH
K63-s	HSHSFDIkPFTTVDF
Y95	PMVADYKYDLKLQEY
Y102	YDLKLQEYQSAIkVE
K107-s	QEYQSAIkVEPAsPP
S112-p	AIkVEPAsPPYYSEK
Y173-p	TIRLKLIyDRCDLNC
K268-a	ARAILTGkTTDKsPF
S273-p	TGkTTDKsPFVIYDM
K293-a	GEDKIKFkHITPLQE
S317-p	FQGCQFRsVEAVQEI
K395	FGDFMEPKFEFAVKF

	PPAR-gamma iso2
S16-p	WPTNFGIsSVDLsVM
S21-p	GIsSVDLsVMEDHSH
K33	HSHSFDIKPFTTVDF
Y65	PMVADYKYDLKLQEY
Y72	YDLKLQEYQSAIkVE
K77-s	QEYQSAIkVEPAsPP
S82-p	AIkVEPAsPPYYSEK
Y143	TIRLKLIYDRCDLNC
K238	ARAILTGKTTDKSPF
S243	TGKTTDKSPFVIYDM
K263	GEDKIKFKHITPLQE
S287	FQGCQFRSVEAVQEI
K365-s	FGDFMEPkFEFAVKF

	rat
S46	WPTNFGISSVDLSVM
S51	GISSVDLSVMDDHSH
K63	HSHSFDIKPFTTVDF
Y95	PMVADYKYDLKLQEY
Y102	YDLKLQEYQSAIKVE
K107	QEYQSAIKVEPASPP
S112	AIKVEPASPPYYSEK
Y173	TIRLKLIYDRCDLNC
K268	ARAILTGKTTDKSPF
S273	TGKTTDKSPFVIYDM
K293	GEDKIKFKHITPLQE
S317	FQGCQFRSVEAVQEI
K395	FGDFMEPKFEFAVKF

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