Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein
Cellular Component: nucleus
Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; metal ion binding; drug binding; receptor activity; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; protein heterodimerization activity; sequence-specific DNA binding; protein complex binding; steroid hormone receptor activity; lipid binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; epidermis development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; wound healing; positive regulation of transcription, DNA-dependent; behavioral response to nicotine; glucose metabolic process; lipoprotein metabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; regulation of gene expression; positive regulation of fatty acid oxidation; regulation of fatty acid metabolic process; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of blood pressure; lipid metabolic process; circadian regulation of gene expression; negative regulation of protein binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.