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Protein Page:
TBX21 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TBX21 Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: cell soma; nucleus
Molecular Function: transcription factor activity
Biological Process: positive regulation of isotype switching to IgG isotypes; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation
Reference #:  Q9UL17 (UniProtKB)
Alt. Names/Synonyms: T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; TBET; TBLYM; TBX21; Transcription factor TBLYM
Gene Symbols: TBX21
Molecular weight: 58,328 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBX21

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y220-p SMPGNRLyVHPDSPN
1 0 Y266-p VLQSLHKyQPRLHIV
1 0 T303 ETQFIAVTAyQNAEI
1 0 Y305-p QFIAVTAyQNAEITQ
1 0 K314 NAEITQLKIDNNPFA
0 1 S513 PSSGDSSSPAGAPSP
1 0 Y530 KEAEGQFYNYFPN__
  mouse

 
Y219 SMPGNRLYVHPDSPN
Y265 VLQSLHKYQPRLHIV
T302-p ETQFIAVtAYQNAEI
Y304 QFIAVtAYQNAEITQ
K313-u NAEITQLkIDNNPFA
S508-p PSSGDSSsPAGAPSP
Y525-p KETEGQFyNYFPN__
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