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TBX21 (human)

Overview TBX21 Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cell soma; nucleus Molecular Function: transcription factor activity Biological Process: positive regulation of isotype switching to IgG isotypes; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to virus; multicellular organismal development; positive regulation of transcription, DNA-dependent; T cell differentiation Reference #:  Q9UL17 (UniProtKB) Alt. Names/Synonyms: T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; TBET; TBLYM; TBX21; Transcription factor TBLYM Gene Symbols: TBX21 Molecular weight: 58,328 Da Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TBX21

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 208550 604895  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y58-p	GGSLGSPyPGGALVP
0	1		S213	QCGKAEGSMPGNRLy
1	0		Y220-p	SMPGNRLyVHPDSPN
0	1		S251-p	LTNNKGAsNNVtQMI
0	1		T255-p	KGAsNNVtQMIVLQs
0	1		S262-p	tQMIVLQsLHKyQPR
1	0		Y266-p	VLQsLHKyQPRLHIV
1	0		Y305-p	QFIAVTAyQNAEITQ
0	1		Y395-p	GAPRDHSyEAEFRAV
0	1		S512-p	YPSSGDSsSPAGAPS
0	1		S513	PSSGDSsSPAGAPSP
1	0		Y530	KEAEGQFYNYFPN__

	mouse
Y57	GSSLGTPYSGGALVP
S212-p	QCGKAEGsMPGNRLY
Y219	sMPGNRLYVHPDSPN
S250	LTNNKGASNNVTQMI
T254	KGASNNVTQMIVLQS
S261	TQMIVLQSLHKYQPR
Y265	VLQSLHKYQPRLHIV
Y304	QFIAVTAYQNAEITQ
Y394	GTPREHSYEAEFRAV
S507	YPSSGDSSsPAGAPS
S508-p	PSSGDSSsPAGAPSP
Y525-p	KETEGQFyNYFPN__

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