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Protein Page:
TBX21 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBX21 Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: cell soma; nucleus
Molecular Function: transcription factor activity
Biological Process: positive regulation of isotype switching to IgG isotypes; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; multicellular organismal development; positive regulation of transcription, DNA-dependent; T cell differentiation
Reference #:  Q9UL17 (UniProtKB)
Alt. Names/Synonyms: T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; TBET; TBLYM; TBX21; Transcription factor TBLYM
Gene Symbols: TBX21
Molecular weight: 58,328 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TBX21

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y58-p GGSLGSPyPGGALVP
0 1 S213 QCGKAEGSMPGNRLy
1 0 Y220-p SMPGNRLyVHPDSPN
0 1 S251-p LTNNKGAsNNVtQMI
0 1 T255-p KGAsNNVtQMIVLQs
0 1 S262-p tQMIVLQsLHKyQPR
1 0 Y266-p VLQsLHKyQPRLHIV
1 0 T303 ETQFIAVTAyQNAEI
1 0 Y305-p QFIAVTAyQNAEITQ
1 0 K314 NAEITQLKIDNNPFA
0 1 Y395-p GAPRDHSyEAEFRAV
0 1 S512-p YPSSGDSsSPAGAPS
0 1 S513 PSSGDSsSPAGAPSP
1 0 Y530 KEAEGQFYNYFPN__
  mouse

 
Y57 GSSLGTPYSGGALVP
S212-p QCGKAEGsMPGNRLY
Y219 sMPGNRLYVHPDSPN
S250 LTNNKGASNNVTQMI
T254 KGASNNVTQMIVLQS
S261 TQMIVLQSLHKYQPR
Y265 VLQSLHKYQPRLHIV
T302-p ETQFIAVtAYQNAEI
Y304 QFIAVtAYQNAEITQ
K313-ub NAEITQLkIDNNPFA
Y394 GTPREHSYEAEFRAV
S507 YPSSGDSSsPAGAPS
S508-p PSSGDSSsPAGAPSP
Y525-p KETEGQFyNYFPN__
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