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Protein Page:
TLR7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TLR7 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; lysosome; endoplasmic reticulum; cytoplasm; integral to membrane; plasma membrane; endosome membrane; receptor complex; endosome
Molecular Function: transmembrane receptor activity; siRNA binding; single-stranded RNA binding; double-stranded RNA binding; drug binding
Biological Process: positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-6 production; pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 7 signaling pathway; positive regulation of chemokine production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; inflammatory response; I-kappaB phosphorylation; defense response to virus; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response
Reference #:  Q9NYK1 (UniProtKB)
Alt. Names/Synonyms: TLR7; Toll-like receptor 7
Gene Symbols: TLR7
Molecular weight: 120,922 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TLR7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S22-p LFNIILIsKLLGARW
0 1 K293-ub FDALTELkVLRLHSN
0 1 S359-p ELQVYRAsMNLSQAF
0 14 S371-p QAFSSLKsLKILRIR
0 1 S609-p MMNDNDIssSTSRTM
0 1 S610-p MNDNDIssSTSRTME
0 1 S722-p PERLSNCsRsLKNLI
0 1 S724-p RLSNCsRsLKNLILK
0 1 Y807-p HTEVTIPyLATDVTC
0 1 Y881 CKAKIKGYQRLISPD
0 1 S974 FKIAFYLSHQRLMDE
  mouse

 
S22 FLNMLLVSRVFGFRW
K293 FNSLTELKVLRLHSN
S359 ELQVYHASITLPHSL
N371 HSLSSLENLKILRVK
S610 MMNDNDISTSASRTM
T611 MNDNDISTSASRTME
S723 PERLANCSKSLTTLI
S725 RLANCSKSLTTLILK
Y808 HTDVTIPYLATDVTC
Y882-p WKAKIKGyQHLQSME
S975-p FKMAFYLsHQRLLDE
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