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TLR7 (human)

Overview TLR7 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum; lysosome; cytoplasm; integral to membrane; plasma membrane; endosome membrane; endosome Molecular Function: single-stranded RNA binding; siRNA binding; double-stranded RNA binding; drug binding Biological Process: pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 7 signaling pathway; positive regulation of chemokine production; response to chemical stimulus; positive regulation of interleukin-8 production; positive regulation of interferon-beta biosynthetic process; innate immune response; I-kappaB phosphorylation; inflammatory response; defense response to virus; microglial cell activation during immune response; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response Reference #:  Q9NYK1 (UniProtKB) Alt. Names/Synonyms: TLR7; Toll-like receptor 7 Gene Symbols: TLR7 Molecular weight: 120,922 Da Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TLR7

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K293-u	FDALTELkVLRLHSN
0	14		S371-p	QAFSSLKsLKILRIR
0	1		S609-p	MMNDNDIssSTSRTM
0	1		S610-p	MNDNDIssSTSRTME
0	1		S722-p	PERLSNCsRsLKNLI
0	1		S724-p	RLSNCsRsLKNLILK
0	1		Y807-p	HTEVTIPyLATDVTC
0	1		Y881	CKAKIKGYQRLISPD
0	1		S974	FKIAFYLSHQRLMDE

	mouse
K293	FNSLTELKVLRLHSN
N371	HSLSSLENLKILRVK
S610	MMNDNDISTSASRTM
T611	MNDNDISTSASRTME
S723	PERLANCSKSLTTLI
S725	RLANCSKSLTTLILK
Y808	HTDVTIPYLATDVTC
Y882-p	WKAKIKGyQHLQSME
S975-p	FKMAFYLsHQRLLDE

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