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Protein Page:
SGCB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SGCB Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCB are the cause of limb-girdle muscular dystrophy type 2E (LGMD2E). LGMD2E is an autosomal recessive disorder. Belongs to the sarcoglycan beta/delta/gamma/zeta family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Dystrophin complex
Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; integral to plasma membrane; cytoplasm; sarcoglycan complex; sarcolemma
Biological Process: muscle development; cardiac cell differentiation
Reference #:  Q16585 (UniProtKB)
Alt. Names/Synonyms: 43 kDa dystrophin-associated glycoprotein; 43DAG; A3b; Beta-sarcoglycan; beta-sarcoglycan(43kD dystrophin-associated glycoprotein); Beta-SG; LGMD2E; limb girdle muscular dystrophy 2E (non-linked families); sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); SGC; SGCB
Gene Symbols: SGCB
Molecular weight: 34,777 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below

SGCB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K41-u KEHNSNFkAGyIPID
0 1 K19 QSSNGPVKKSMREKA
0 3 Y44-p NSNFkAGyIPIDEDR
0 1 K54 IDEDRLHKTGLRGRK
0 1 K111-u ESGLLRFkQVSDMGV
0 1 K124-u GVIHPLYkSTVGGRR
0 1 K152-u VFQQGTTkLSVENNK
0 1 K196-u FHLPSGVkSLNVQkA
0 1 K202-u VkSLNVQkASTERIT
0 1 K219-u ATSDLNIkVDGRAIV
  mouse

 
K43-u KEHNSNFkAGYIPID
K21-u QGSNGPVkKSMREKA
Y46 NSNFkAGYIPIDEDR
K56-u IDEDRLHkTGLRGRK
K113 ESGLLRFKQVSDMGV
K126 GVIHPLYKSTVGGRR
K154 VFQQGTTKLSVEKNK
K198 FHLPSGVKSLNVQKA
K204 VKSLNVQKASTERIT
K221 ATSDLNIKVDGRAIV
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