Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 18.104.22.168
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: early endosome; plasma membrane
Molecular Function: prenylated protein tyrosine phosphatase activity
Alt. Names/Synonyms: potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; PRL3; Protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PTP4A3; TP4A3
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.