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Protein Page:
PTP4A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTP4A3 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48
Cellular Component: early endosome; plasma membrane
Molecular Function: prenylated protein tyrosine phosphatase activity
Reference #:  O75365 (UniProtKB)
Alt. Names/Synonyms: potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; PRL3; Protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PTP4A3; TP4A3
Gene Symbols: PTP4A3
Molecular weight: 19,535 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTP4A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S13 RPAPVEVSyKHMRFL
0 4 Y14-p PAPVEVSyKHMRFLI
0 1 Y40 FIEDLKKYGATTVVR
0 1 K155-ac YLEKYRPkQRLRFKD
0 1 K167-ac FKDPHTHkTRCCVM_
  mouse

 
S13-p RPAPVEVsyRHMRFL
Y14-p PAPVEVsyRHMRFLI
Y40-p FIEDLKKyGATTVVR
K155 YLEKYRPKQRLRFKD
K167 FKDPHTHKTRCCVM_
  rat

 
S13 RPAPVEVSYRHMRFL
Y14 PAPVEVSYRHMRFLI
Y40 FIEDLKKYGATTVVR
K155 YLEKYRPKQRLRFKD
K167 FKDPHTHKTRCCVM_
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