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TMED9
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. Belongs to the EMP24/GP25L family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
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Cellular Component: Golgi apparatus; trans-Golgi network transport vesicle; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; endoplasmic reticulum; ER-Golgi intermediate compartment; integral to membrane
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Molecular Function: protein binding
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Biological Process: COPI coating of Golgi vesicle; protein exit from endoplasmic reticulum; Golgi organization and biogenesis
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Reference #:
Q9BVK6 (UniProtKB)
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| Alt. Names/Synonyms: Glycoprotein 25L2; GP25L2; gp25L2 protein; HSGP25L2G; TMED9; Transmembrane emp24 domain-containing protein 9; transmembrane emp24 protein transport domain containing 9 |
| Gene Symbols: TMED9 |
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Molecular weight: 27,277 Da
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Basal Isoelectric point: 7.81
Predict pI for various phosphorylation states
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