Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TMED9 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TMED9 Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. Belongs to the EMP24/GP25L family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: Golgi membrane; Golgi apparatus; trans-Golgi network transport vesicle; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; endoplasmic reticulum; ER-Golgi intermediate compartment; integral to membrane
Molecular Function: protein binding; syntaxin binding
Biological Process: COPI coating of Golgi vesicle; protein exit from endoplasmic reticulum; Golgi organization and biogenesis
Reference #:  Q9BVK6 (UniProtKB)
Alt. Names/Synonyms: Glycoprotein 25L2; GP25L2; gp25L2 protein; HSGP25L2G; TMED9; Transmembrane emp24 domain-containing protein 9; transmembrane emp24 protein transport domain containing 9
Gene Symbols: TMED9
Molecular weight: 27,277 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Select Structure to View Below

TMED9

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 K71-u YRTQLYDkQREEYQP
0 1 K90-u LGMFVEVkDPEDKVI
0 5 K160-u AEIAAKDkLSELQLR
0 72 K180-u EQVEQIQkEQNYQRW
0 4 K226-u VWQMRHLkSFFEAkK
0 2 K232-u LkSFFEAkKLV____
  mouse

 
K71 YRTQLYDKQREEYQP
K90 LGMFVEVKDPEDKVI
K160 AEIAAKDKLSELQLR
K180-u EQVEQIQkEQNYQRW
K226 VWQMRHLKSFFEAKK
K232 LKSFFEAKKLV____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.