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Protein Page:
PLCG1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 3.1.4.11
Cellular Component: signalosome; ruffle; lamellipodium; cytoplasm; plasma membrane; cytosol
Molecular Function: glutamate receptor binding; protein binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; inositol phosphate metabolic process; fibroblast growth factor receptor signaling pathway; viral reproduction; nerve growth factor receptor signaling pathway; activation of MAPKK activity; in utero embryonic development; phospholipid catabolic process; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; blood coagulation; leukocyte migration
Reference #:  P19174 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC-148; PLC-gamma-1; PLC-II; PLC1; PLC148; PLCG1; PLCgamma1; triphosphoinositide phosphodiesterase
Gene Symbols: PLCG1
Molecular weight: 148,532 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCG1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell motility, altered: Y783‑p
enzymatic activity, induced: Y783‑p
molecular association, regulation: Y783‑p
phosphorylation: Y783‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K178-u RISAKDLkNMLSQVN
0 4 Y186-p NMLSQVNyRVPNMRF
0 10 Y210-p QRSGDITyGQFAQLY
0 2 Y217 yGQFAQLYRSLMYSA
0 2 K226-u SLMYSAQkTMDLPFL
0 10 Y379-p PDGMPVIyHGHTLTT
0 1 T383 PVIyHGHTLTTKIkF
0 1 T385 IyHGHTLTTKIkFSD
0 1 T386 yHGHTLTTKIkFSDV
0 1 K389-u HTLTTKIkFSDVLHT
0 7 Y428-p QQRNMAQyFKkVLGD
0 3 K431-u NMAQyFKkVLGDTLL
0 3 K440-u LGDTLLTkPVEISAD
0 9 S470-p HKKLAEGsAyEEVPT
2 133 Y472-p KLAEGsAyEEVPTSM
0 82 Y481-p EVPTSMMySENDISN
0 3 Y496-p SIKNGILyLEDPVNH
0 31 Y506-p DPVNHEWyPHyFVLT
3 8 Y509-p NHEWyPHyFVLTSSK
0 4 Y518-p VLTSSKIyYSEETSs
0 1 S525-p yYSEETSsDQGNEDE
0 1 T542-p PKEVSSStELHSNEK
0 10 Y702-p KRNEPNSyAISFRAE
0 2 T766-p EALEKIGtAEPdyGA
0 1 D770-ca KIGtAEPdyGALyEG
11 567 Y771-p IGtAEPdyGALyEGR
2 392 Y775-p EPdyGALyEGRNPGF
61 558 Y783-p EGRNPGFyVEANPMP
0 7 Y833-p GGWWRGDyGGKKQLW
0 2 K941-u DARLTEGkIMERRKK
0 35 Y959-p ELSELVVyCRPVPFD
0 675 Y977-p IGTERACyRDMsSFP
0 3 S981-p RACyRDMsSFPETKA
0 7 Y991-p PETKAEKyVNKAKGK
0 24 Y1003-p KGKKFLQyNRLQLSR
0 1 K1215 KIDIFPAKENGDLsP
0 65 S1221-p AKENGDLsPFsGtsL
0 5 S1224-p NGDLsPFsGtsLRER
0 5 T1226-p DLsPFsGtsLRERGs
0 30 S1227-p LsPFsGtsLRERGsD
0 32 S1233-p tsLRERGsDAsGQLF
0 6 S1236-p RERGsDAsGQLFHGR
3 241 S1248-p HGRAREGsFEsRyQQ
0 14 S1251-p AREGsFEsRyQQPFE
10 62 Y1253-p EGsFEsRyQQPFEDF
0 55 S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  PLCG1 iso2  
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
K226 SLMYSAQKTMDLPFL
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVEISAD
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSM
Y481 EVPTSMMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHYFVLT
Y509 NHEWYPHYFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
T542 PKEVSSSTELHSNEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDYGA
D770 KIGTAEPDYGALYEG
Y771 IGTAEPDYGALYEGR
Y775 EPDYGALYEGRNPGF
Y783 EGRNPGFYVEANPMP
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKIMERRKK
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKQENGDLs
S1222-p KQENGDLsPFsGtsL
S1225-p NGDLsPFsGtsLRER
T1227-p DLsPFsGtsLRERGs
S1228-p LsPFsGtsLRERGsD
S1234-p tsLRERGsDAsGQLF
S1237-p RERGsDAsGQLFHGR
S1249 HGRAREGSFESRYQQ
S1252 AREGSFESRYQQPFE
Y1254 EGSFESRYQQPFEDF
S1264 PFEDFRISQEHLADH
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
  mouse

 
K178-u RISAKDLkNMLSQVN
Y186-p NMLSQVNyRVPNMRF
Y210-p QRSGDITyGQFAQLy
Y217-p yGQFAQLyRSLMYSA
K226-u SLMYSAQkTMDLPFL
Y379-p PDGMPVIyHGHtLtt
T383-p PVIyHGHtLttKIKF
T385-p IyHGHtLttKIKFSD
T386-p yHGHtLttKIKFSDV
K389 HtLttKIKFSDVLHT
H428 QQRNMAQHFRkVLGD
K431-u NMAQHFRkVLGDTLL
K440-u LGDTLLTkPVDIAAD
S470 HKKLAEGSAyEEVPT
Y472-p KLAEGSAyEEVPTSV
Y481-p EVPTSVMySENDISN
Y496-p SIKNGILyLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSs
S525-p YYSEETSsDQGNEDE
T542 PKEASSSTELHSSEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
Y833 GGWWRGDYGGKKQLW
K941-u DARLTEGkMMERRKK
Y959 ELSELVVYCRPVPFD
Y977-p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215-u KIDIFPAkENGDLsP
S1221-p AkENGDLsPFsGIsL
S1224-p NGDLsPFsGIsLRER
I1226 DLsPFsGIsLRERAS
S1227-p LsPFsGIsLRERASD
S1233 IsLRERASDAsSQLF
S1236-p RERASDAsSQLFHVR
S1248-p HVRAREGsFEARyQQ
A1251 AREGsFEARyQQPFE
Y1253-p EGsFEARyQQPFEDF
S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  rat

 
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
K226 SLMYSAQKTMDLPFL
Y379-p PDGMPVIyHGHTLTT
T383 PVIyHGHTLTTKIKF
T385 IyHGHTLTTKIKFSD
T386 yHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
H428 QQRNMAQHFRKVLGD
K431 NMAQHFRKVLGDTLL
K440 LGDTLLTKPVDIAAD
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSV
Y481-p EVPTSVMySENDISN
Y496 SIKNGILYLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
T542 PKEASGSTELHSSEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
Y959 ELSELVVYCRPVPFD
Y977-p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKENGDLSP
S1221 AKENGDLSPFSGTSL
S1224 NGDLSPFSGTSLRER
T1226 DLSPFSGTSLRERAS
S1227 LSPFSGTSLRERASD
S1233 TSLRERASDASSQLF
S1236 RERASDASSQLFHVR
S1248 HVRAREGSFEARyQQ
A1251 AREGSFEARyQQPFE
Y1253-p EGSFEARyQQPFEDF
S1263 PFEDFRISQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  cow

 
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRTSDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
K226 SLMYSAQKTMDLPFL
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVDIAAD
S470 HKKLAEGSAyEEVPT
Y472-p KLAEGSAyEEVPTSV
Y481 EVPTSVMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHyFVLT
Y509-p NHEWYPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
T542 PKEASGSTELHSNEK
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDVFPAKQENGDLS
S1222 KQENGDLSPFGGASL
G1225 NGDLSPFGGASLRER
A1227 DLSPFGGASLRERSC
S1228 LSPFGGASLRERSCD
C1234 ASLRERSCDASGPLF
S1237 RERSCDASGPLFHGR
S1249 HGRAREGSFEARyQQ
A1252 AREGSFEARyQQPFE
Y1254-p EGSFEARyQQPFEDF
S1264 PFEDFRISQEHLADH
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