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Protein Page:
PLCG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q12-q13.1
Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; cytosol
Molecular Function: glutamate receptor binding; protein binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; protein kinase binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; inositol phosphate metabolic process; fibroblast growth factor receptor signaling pathway; viral reproduction; activation of MAPKK activity; nerve growth factor receptor signaling pathway; phospholipid catabolic process; in utero embryonic development; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; blood coagulation; leukocyte migration
Reference #:  P19174 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC-148; PLC-gamma-1; PLC-II; PLC1; PLC148; PLCG1; PLCgamma1; triphosphoinositide phosphodiesterase
Gene Symbols: PLCG1
Molecular weight: 148,532 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCG1

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: Y783‑p
enzymatic activity, induced: Y783‑p
molecular association, regulation: Y783‑p
phosphorylation: Y783‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S6-p __MAGAAsPCANGCG
0 1 Y93-p TSRDFDRyQEDPAFR
0 2 K178-ub RISAKDLkNMLSQVN
0 4 Y186-p NMLSQVNyRVPNMRF
0 10 Y210-p QRSGDITyGQFAQLY
0 2 Y217 yGQFAQLYRsLMYSA
0 1 S219-p QFAQLYRsLMYSAQk
0 2 K226-ub sLMYSAQkTMDLPFL
0 1 S236-p DLPFLEAstLRAGER
0 2 T237-p LPFLEAstLRAGERP
0 11 Y379-p PDGMPVIyHGHTLTT
0 1 T383 PVIyHGHTLTTKIkF
0 1 T385 IyHGHTLTTKIkFSD
0 1 T386 yHGHTLTTKIkFSDV
0 1 K389-ub HTLTTKIkFSDVLHT
0 1 S412-p SEYPVILsIEDHCSI
0 7 Y428-p QQRNMAQyFKkVLGD
0 3 K431-ub NMAQyFKkVLGDTLL
0 3 K440-ub LGDTLLTkPVEISAD
0 1 S451-p ISADGLPsPNQLKRK
0 11 S470-p HKKLAEGsAyEEVPt
3 111 Y472-p KLAEGsAyEEVPtSM
0 1 T477-p sAyEEVPtSMMySEN
1 68 Y481-p EVPtSMMySENDISN
0 3 Y496-p SIKNGILyLEDPVNH
0 31 Y506-p DPVNHEWyPHyFVLT
3 8 Y509-p NHEWyPHyFVLTSSK
0 4 Y518-p VLTSSKIyYSEETSs
0 3 S525-p yYSEETSsDQGNEDE
0 1 S539-p EEEPKEVsSStELHS
0 1 T542-p PKEVsSStELHSNEK
0 1 Y669-p AHESKEWyHASLTRA
0 10 Y702-p KRNEPNSyAISFRAE
0 2 T766-p EALEKIGtAEPdyGA
0 1 D770-ca KIGtAEPdyGALyEG
14 562 Y771-p IGtAEPdyGALyEGR
2 365 Y775-p EPdyGALyEGRNPGF
64 553 Y783-p EGRNPGFyVEANPMP
0 2 T791-p VEANPMPtFKCAVKA
0 9 Y833-p GGWWRGDyGGKKQLW
0 2 K941-ub DARLTEGkIMERRKK
0 1 S954-p KKIALELsELVVyCR
0 38 Y959-p ELsELVVyCRPVPFD
0 662 Y977-p IGTERACyRDMssFP
0 3 S981-p RACyRDMssFPETKA
0 1 S982-p ACyRDMssFPETKAE
0 9 Y991-p PETKAEKyVNKAKGK
1 25 Y1003-p KGKKFLQyNRLQLSR
0 1 K1215 KIDIFPAKENGDLsP
0 72 S1221-p AKENGDLsPFsGtsL
0 5 S1224-p NGDLsPFsGtsLRER
0 5 T1226-p DLsPFsGtsLRERGs
0 31 S1227-p LsPFsGtsLRERGsD
0 34 S1233-p tsLRERGsDAsGQLF
0 6 S1236-p RERGsDAsGQLFHGR
3 247 S1248-p HGRAREGsFEsRyQQ
0 14 S1251-p AREGsFEsRyQQPFE
12 75 Y1253-p EGsFEsRyQQPFEDF
0 55 S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
14008 : Phospho-PLC gamma1 (Tyr783) (D6M9S) Rabbit mAb
14461 : Phospho-PLCgamma1 (Tyr783) (D6M9S) Rabbit mAb (PE Conjugate)
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  PLCG1 iso2  
S6 __MAGAASPCANGCG
Y93 TSRDFDRYQEDPAFR
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
S236 DLPFLEASTLRAGER
T237 LPFLEASTLRAGERP
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVEISAD
S451 ISADGLPSPNQLKRK
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSM
T477 SAYEEVPTSMMYSEN
Y481 EVPTSMMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHYFVLT
Y509 NHEWYPHYFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEVSSSTELHS
T542 PKEVSSSTELHSNEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDYGA
D770 KIGTAEPDYGALYEG
Y771 IGTAEPDYGALYEGR
Y775 EPDYGALYEGRNPGF
Y783 EGRNPGFYVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKIMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
S982 ACYRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKQENGDLs
S1222-p KQENGDLsPFsGtsL
S1225-p NGDLsPFsGtsLRER
T1227-p DLsPFsGtsLRERGs
S1228-p LsPFsGtsLRERGsD
S1234-p tsLRERGsDAsGQLF
S1237-p RERGsDAsGQLFHGR
S1249 HGRAREGSFESRYQQ
S1252 AREGSFESRYQQPFE
Y1254 EGSFESRYQQPFEDF
S1264 PFEDFRISQEHLADH
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
  mouse

 
T6 __MAGVATPCANGCG
Y93 TSRDFDRYQEDPAFR
K178-ub RISAKDLkNMLSQVN
Y186-p NMLSQVNyRVPNMRF
Y210-p QRSGDITyGQFAQLy
Y217-p yGQFAQLyRSLMYSA
S219 QFAQLyRSLMYSAQk
K226-ub SLMYSAQkTMDLPFL
N236 DLPFLETNALRTGER
A237 LPFLETNALRTGERP
Y379-p PDGMPVIyHGHtLtt
T383-p PVIyHGHtLttKIKF
T385-p IyHGHtLttKIKFSD
T386-p yHGHtLttKIKFSDV
K389 HtLttKIKFSDVLHT
S412 SEYPVILSIEDHCSI
H428 QQRNMAQHFRkVLGD
K431-ub NMAQHFRkVLGDTLL
K440-ub LGDTLLTkPVDIAAD
S451 IAADGLPSPNQLRRK
S470 HKKLAEGSAyEEVPT
Y472-p KLAEGSAyEEVPTSV
T477 SAyEEVPTSVMySEN
Y481-p EVPTSVMySENDISN
Y496-p SIKNGILyLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSs
S525-p YYSEETSsDQGNEDE
S539 EEEPKEASSSTELHS
T542 PKEASSSTELHSSEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941-ub DARLTEGkMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977-p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
S982 ACyRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215-ub KIDIFPAkENGDLsP
S1221-p AkENGDLsPFsGIsL
S1224-p NGDLsPFsGIsLRER
I1226 DLsPFsGIsLRERAS
S1227-p LsPFsGIsLRERASD
S1233 IsLRERASDAsSQLF
S1236-p RERASDAsSQLFHVR
S1248-p HVRAREGsFEARyQQ
A1251 AREGsFEARyQQPFE
Y1253-p EGsFEARyQQPFEDF
S1263-p PFEDFRIsQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
14008 : Phospho-PLC gamma1 (Tyr783) (D6M9S) Rabbit mAb
14461 : Phospho-PLCgamma1 (Tyr783) (D6M9S) Rabbit mAb (PE Conjugate)
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  rat

 
T6 __MAGVGTPCANGCG
Y93 TSRDFDRYQEDPAFR
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
N236 DLPFLETNTLRTGER
T237 LPFLETNTLRTGERP
Y379-p PDGMPVIyHGHTLTT
T383 PVIyHGHTLTTKIKF
T385 IyHGHTLTTKIKFSD
T386 yHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
H428 QQRNMAQHFRKVLGD
K431 NMAQHFRKVLGDTLL
K440 LGDTLLTKPVDIAAD
S451 IAADGLPSPNQLKRK
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSV
T477 SAYEEVPTSVMySEN
Y481-p EVPTSVMySENDISN
Y496 SIKNGILYLEDPVNH
Y506-p DPVNHEWyPHyFVLT
Y509-p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEASGSTELHS
T542 PKEASGSTELHSSEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977-p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
S982 ACyRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDIFPAKENGDLsP
S1221-p AKENGDLsPFSGTSL
S1224 NGDLsPFSGTSLRER
T1226 DLsPFSGTSLRERAS
S1227 LsPFSGTSLRERASD
S1233 TSLRERASDASSQLF
S1236 RERASDASSQLFHVR
S1248-p HVRAREGsFEARyQQ
A1251 AREGsFEARyQQPFE
Y1253-p EGsFEARyQQPFEDF
S1263 PFEDFRISQEHLADH
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
14008 : Phospho-PLC gamma1 (Tyr783) (D6M9S) Rabbit mAb
14461 : Phospho-PLCgamma1 (Tyr783) (D6M9S) Rabbit mAb (PE Conjugate)
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  cow

 
S6 __MAGAASPCANGCG
Y93 TSRDFDRYQEDPAFR
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRTSDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
S236 DLPFLEASALRAGER
A237 LPFLEASALRAGERP
Y379 PDGMPVIYHGHTLTT
T383 PVIYHGHTLTTKIKF
T385 IYHGHTLTTKIKFSD
T386 YHGHTLTTKIKFSDV
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVDIAAD
S451 IAADGLPSPNQLKRK
S470 HKKLAEGSAyEEVPT
Y472-p KLAEGSAyEEVPTSV
T477 SAyEEVPTSVMYSEN
Y481 EVPTSVMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHyFVLT
Y509-p NHEWYPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEASGSTELHS
T542 PKEASGSTELHSNEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771-p IGTAEPDyGALyEGR
Y775-p EPDyGALyEGRNPGF
Y783-p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
S982 ACYRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1215 KIDVFPAKQENGDLS
S1222 KQENGDLSPFGGASL
G1225 NGDLSPFGGASLRER
A1227 DLSPFGGASLRERSC
S1228 LSPFGGASLRERSCD
C1234 ASLRERSCDASGPLF
S1237 RERSCDASGPLFHGR
S1249 HGRAREGSFEARyQQ
A1252 AREGSFEARyQQPFE
Y1254-p EGSFEARyQQPFEDF
S1264 PFEDFRISQEHLADH
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