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HIST2H2AB (human)

Overview HIST2H2AB Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleosome; nucleus Molecular Function: DNA binding; protein heterodimerization activity Biological Process: nucleosome assembly Reference #:  Q8IUE6 (UniProtKB) Alt. Names/Synonyms: H2A2B; HIST2H2AB; histone 2, H2ab; histone cluster 2, H2ab; Histone H2A type 2-B Gene Symbols: HIST2H2AB Molecular weight: 13,995 Da Basal Isoelectric point: 10.88  Predict pI for various phosphorylation states

Select Structure to View Below HIST2H2AB

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	94		K6-a	__MSGRGkQGGkARA
0	93		K10-a	GRGkQGGkARAkAKS
0	1		K14-a	QGGkARAkAKSRSSR
0	14		K37-u	RVHRLLRkGNYAERV
0	3		R89-m1	RHLQLAVrNDEELNk
0	20		K96-u	rNDEELNkLLGGVtI
0	3		T102-p	NkLLGGVtIAQGGVL
0	16		K119-a	IQAVLLPkktESHkP
0	147		K119-u	IQAVLLPkktESHkP
0	138		K120-u	QAVLLPkktESHkPG
0	1		K120-m2	QAVLLPkktESHkPG
0	12		K120-a	QAVLLPkktESHkPG
0	1		T121-p	AVLLPkktESHkPGk
0	103		K125-u	PkktESHkPGkNk__
0	1		K128-m2	tESHkPGkNk_____
0	34		K128-u	tESHkPGkNk_____
0	2		K130-u	SHkPGkNk_______

	mouse
K6-a	__MSGRGkQGGkARA
K10-a	GRGkQGGkARAKAKS
K14	QGGkARAKAKSRSSR
K37-u	RVHRLLRkGNYAERV
R89	RHLQLAVRNDEELNk
K96-u	RNDEELNkLLGGVtI
T102-p	NkLLGGVtIAQGGVL
K119-a	IQAVLLPkkTESHkP
K119-u	IQAVLLPkkTESHkP
K120-u	QAVLLPkkTESHkPG
K120	QAVLLPkKTESHkPG
K120-a	QAVLLPkkTESHkPG
T121	AVLLPkkTESHkPGK
K125-u	PkkTESHkPGKNK__
K128	TESHkPGKNK_____
K128	TESHkPGKNK_____
K130	SHkPGKNK_______

	rat
K6	__MSGRGKQGGKARA
K10	GRGKQGGKARAKAKS
K14	QGGKARAKAKSRSSR
K37	RVHRLLRKGNYAERV
R89-m1	RHLQLAVrNDEELNK
K96	rNDEELNKLLGGVTI
T102	NKLLGGVTIAQGGVL
K119	IQAVLLPKKTDSHKP
K119	IQAVLLPKKTDSHKP
K120	QAVLLPKKTDSHKPG
K120	QAVLLPKKTDSHKPG
K120	QAVLLPKKTDSHKPG
T121	AVLLPKKTDSHKPGK
K125	PKKTDSHKPGKNK__
K128	TDSHKPGKNK_____
K128	TDSHKPGKNK_____
K130	SHKPGKNK_______

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