|
AP1S3
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: Transporter; Vesicle protein; Adaptor/scaffold |
|
Cellular Component: Golgi membrane; cytoplasmic vesicle membrane; membrane coat; lysosomal membrane; trans-Golgi network membrane; coated pit; cytosol
|
|
Molecular Function: protein transporter activity
|
|
Biological Process: intracellular protein transport; viral reproduction; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; post-Golgi vesicle-mediated transport; membrane organization and biogenesis; regulation of defense response to virus by virus
|
|
Reference #:
Q96PC3 (UniProtKB)
|
| Alt. Names/Synonyms: Adapter-related protein complex 1 sigma-1C subunit; Adaptor protein complex AP-1 sigma-1C subunit; adaptor-related protein complex 1, sigma 3 subunit; AP-1 complex subunit sigma-3; AP1S3; Clathrin assembly protein complex 1 sigma-1C small chain; Golgi adaptor HA1/AP1 adaptin sigma-1C subunit; sigma 1C adaptin; Sigma 1C subunit of AP-1 clathrin; Sigma-adaptin 1C; Sigma1C-adaptin |
| Gene Symbols: AP1S3 |
|
Molecular weight: 18,280 Da
|
|
Basal Isoelectric point: 6.32
Predict pI for various phosphorylation states
|
