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Protein Page:
AP1S3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

AP1S3 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: Golgi membrane; membrane coat; cytoplasmic vesicle membrane; lysosomal membrane; trans-Golgi network membrane; coated pit; cytosol
Molecular Function: protein binding; protein transporter activity
Biological Process: viral reproduction; antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport; regulation of defense response to virus by virus; protein targeting
Disease: Psoriasis 15, Pustular, Susceptibility To
Reference #:  Q96PC3 (UniProtKB)
Alt. Names/Synonyms: Adapter-related protein complex 1 sigma-1C subunit; Adaptor protein complex AP-1 sigma-1C subunit; adaptor-related protein complex 1, sigma 3 subunit; AP-1 complex subunit sigma-3; AP1S3; Clathrin assembly protein complex 1 sigma-1C small chain; Golgi adaptor HA1/AP1 adaptin sigma-1C subunit; sigma 1C adaptin; Sigma 1C subunit of AP-1 clathrin; Sigma-adaptin 1C; Sigma1C-adaptin
Gene Symbols: AP1S3
Molecular weight: 18,280 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


► Hide Isoforms
  AP1S3 iso4  

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