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Protein Page:
PLCB3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCB3 a phosphatidylinositol-specific phospholipase C. Binds to calmodulin. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Cellular Component: protein complex; membrane; nucleolus; nucleus; cytosol
Molecular Function: calmodulin binding; signal transducer activity; calcium ion binding; phospholipase C activity; phosphoinositide phospholipase C activity
Biological Process: synaptic transmission; inositol phosphate metabolic process; regulation of systemic arterial blood pressure; lipid catabolic process
Reference #:  Q01970 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; FLJ37084; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-3; phospholipase C beta 3; phospholipase C, beta 3 (phosphatidylinositol-specific); Phospholipase C-beta-3; PLC beta 3; PLC-beta-3; PLCB3
Gene Symbols: PLCB3
Molecular weight: 138,799 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCB3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
enzymatic activity, inhibited: S1105‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S26 VETLRRGSKFIKWDE
0 1 Q283 IEKYEPNQQFLERDQ
0 1 Y428-p QQAKMAEyCRSIFGD
0 1 Y445 LIEPLDKYPLAPGVP
0 1 A448 PLDKYPLAPGVPLPS
0 1 V451 KYPLAPGVPLPSPQD
0 1 S455 APGVPLPSPQDLMGR
0 1 S474-p NKKRHRPsAGGPDSA
0 2 A475 KKRHRPsAGGPDSAG
0 1 A481 sAGGPDSAGRKRPLE
0 1 S492 RPLEQSNSALSESSA
4 22 S537-p PSLEPQKsLGDEGLN
0 1 G542 QKsLGDEGLNRGPyV
0 4 Y548-p EGLNRGPyVLGPADR
0 1 K641 MEFVEYNKQQLSRIY
0 1 S734 ALRVKVISGQFLSDR
0 2 K804-u AAFEEGGkFVGHRIL
0 1 S814-p GHRILPVsAIRSGYH
0 3 Y847-p IYTEASDyIPDDHQD
0 25 Y855-p IPDDHQDyAEALINP
0 1 T924-p PRRPPGPtTsPASTs
0 1 S926-p RPPGPtTsPASTsLs
0 1 S931-p tTsPASTsLssPGQR
0 1 S933-p sPASTsLssPGQRDD
0 4 S934-p PASTsLssPGQRDDL
0 1 K1029-u KEGEDEAkRyQEFQN
0 1 Y1031-p GEDEAkRyQEFQNRQ
4 220 S1105-p LDRKRHNsIsEAKMR
0 13 S1107-p RKRHNsIsEAKMRDK
0 1 T1122-p HKKEAELtEINRRHI
0 2 T1130-p EINRRHItESVNSIR
2481 : Phospho-PLCbeta3 (Ser537) Antibody
2484 : Phospho-PLCbeta3 (Ser1105) Antibody
  mouse

 
S26 VETLRRGSKFIKWDE
K283-u IEKYETNkQFLERDQ
Y428 QQAKMAEYCRSIFGD
Y445 LIDPLDKYPLSAGIP
S448 PLDKYPLSAGIPLPS
I451 KYPLSAGIPLPSPQD
S455 SAGIPLPSPQDLMGR
S474 NKKRHRPStGVPDSs
T475-p KKRHRPStGVPDSsV
S481-p StGVPDSsVRKRPLE
S492-p RPLEQSNsALSESSA
S537-p TSLEPQKsLGEEsLS
S542-p QKsLGEEsLSREPNV
N548 EsLSREPNVPMPDRD
K642-u MEFVEYNkQQLSRIY
S735-p ALRVKVIsGQFLSDK
K805-u AAFEEGGkFVGHRIL
S815 GHRILPVSAIRSGYH
Y848 IYTEASDYIPDDHQD
Y856-p IPDDHQDyAEALINP
T925 PRWPPGPTTSSTSSS
S927 WPPGPTTSSTSSSLS
S932 TTSSTSSSLSSPGQR
S934 SSTSSSLSSPGQRDD
S935 STSSSLSSPGQRDDL
K1029 VKEEEEAKQYREFQN
Y1031 EEEEAKQYREFQNRQ
S1105-p LDRKRNNsIsEAKTR
S1107-p RKRNNsIsEAKTREK
T1122 HKKEVELTEINRRHI
T1130 EINRRHITESVNSIR
2481 : Phospho-PLCbeta3 (Ser537) Antibody
2484 : Phospho-PLCbeta3 (Ser1105) Antibody
  rat

 
S26-p VETLRRGsKFIKWDE
K281 IEKYEPNKQFLERDQ
Y426 QQAKMAEYCRSIFGE
Y443-p LIDPLDKyPLsAGtP
S446-p PLDKyPLsAGtPLPs
T449-p KyPLsAGtPLPsPQD
S453-p sAGtPLPsPQDLMGR
S472 NKKRHRPSTGVPDSS
T473 KKRHRPSTGVPDSSV
S479 STGVPDSSVAKRPLE
S490 RPLEQSNSALSESSA
S535-p TSLEPQKsLGEEGLN
G540 QKsLGEEGLNRGPNV
N546 EGLNRGPNVLMPDRD
K640 MEFVEYNKQQLSRIY
S733 ALRVKVISGQFLSDR
R803 AAFEEGGRFVGHRIL
S813 GHRILPVSAIRSGYH
Y846 IYTEASDYIPDDHQD
Y854 IPDDHQDYAEALINP
T923 PRWPPGPTTSPTSTS
S925 WPPGPTTSPTSTSLS
S930 TTSPTSTSLSSPGQR
S932 SPTSTSLSSPGQRDD
S933 PTSTSLSSPGQRDDL
R1029 EEEKEAARQYREFQN
Y1031 EKEAARQYREFQNRQ
S1105-p LDRKRNNsISEAKTR
S1107 RKRNNsISEAKTREK
T1122 HKKEVELTEINRRHI
T1130 EINRRHITESVNSIR
2481 : Phospho-PLCbeta3 (Ser537) Antibody
2484 : Phospho-PLCbeta3 (Ser1105) Antibody
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