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PLCB3 (human)

Overview PLCB3 a phosphatidylinositol-specific phospholipase C. Binds to calmodulin. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Note: This description may include information from UniProtKB. Protein type: EC 3.1.4.11; Phospholipase; Carbohydrate Metabolism - inositol phosphate Cellular Component: protein complex; cytosol; sarcolemma Molecular Function: calmodulin binding; signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; regulation of systemic arterial blood pressure; post-Golgi vesicle-mediated transport; lipid catabolic process Reference #:  Q01970 (UniProtKB) Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; FLJ37084; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-3; phospholipase C beta 3; phospholipase C, beta 3 (phosphatidylinositol-specific); Phospholipase C-beta-3; PLC beta 3; PLC-beta-3; PLCB3 Gene Symbols: PLCB3 Molecular weight: 138,799 Da Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Phospholipase Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PLCB3 3OHM - B=10-886 (human) 4GNK - D/B=10-1234 E=934-1192 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3OHM 4GNK  |  ENZYME  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: S1105‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S26	VETLRRGSKFIKWDE
0	1		K82	GRYARLPKDPKIREV
0	1		Y279-p	ARLLIEKyEPNQQFL
0	1		Q283	IEKyEPNQQFLERDQ
0	1		Y428-p	QQAKMAEyCRSIFGD
0	1		Y445	LIEPLDKYPLAPGVP
0	1		A448	PLDKYPLAPGVPLPS
0	1		V451	KYPLAPGVPLPSPQD
0	1		S455	APGVPLPSPQDLMGR
0	1		S474-p	NKKRHRPsAGGPDSA
0	2		A475	KKRHRPsAGGPDSAG
0	1		A481	sAGGPDSAGRKRPLE
0	1		S492	RPLEQSNSALSESSA
4	19		S537-p	PSLEPQKsLGDEGLN
0	1		G542	QKsLGDEGLNRGPyV
0	4		Y548-p	EGLNRGPyVLGPADR
0	1		K572-a	EEQTDPKkPTTDEGT
0	1		K641	MEFVEYNKQQLSRIY
0	1		S734	ALRVKVISGQFLSDR
0	1		Y746-p	SDRKVGIyVEVDMFG
0	2		K804-u	AAFEEGGkFVGHRIL
0	1		S814-p	GHRILPVsAIRSGYH
0	3		Y847-p	IYTEASDyIPDDHQD
0	25		Y855-p	IPDDHQDyAEALINP
0	1		T924-p	PRRPPGPtTSPASTs
0	1		S931-p	tTSPASTsLSsPGQR
0	4		S934-p	PASTsLSsPGQRDDL
0	1		K1029-u	KEGEDEAkRyQEFQN
0	1		Y1031-p	GEDEAkRyQEFQNRQ
0	1		K1081-a	DANTTQFkRLKEMNE
4	219		S1105-p	LDRKRHNsIsEAKMR
0	13		S1107-p	RKRHNsIsEAKMRDK
0	1		T1122-p	HKKEAELtEINRRHI
0	2		T1130-p	EINRRHItESVNSIR

	mouse
S26	VETLRRGSKFIKWDE
K82-a	GRYARLPkDPKIREV
Y279	ARLLIEKYETNkQFL
K283-u	IEKYETNkQFLERDQ
Y428	QQAKMAEYCRSIFGD
Y445	LIDPLDKYPLSAGIP
S448	PLDKYPLSAGIPLPS
I451	KYPLSAGIPLPSPQD
S455	SAGIPLPSPQDLMGR
S474	NKKRHRPStGVPDSs
T475-p	KKRHRPStGVPDSsV
S481-p	StGVPDSsVRKRPLE
S492-p	RPLEQSNsALSESSA
S537-p	TSLEPQKsLGEEsLS
S542-p	QKsLGEEsLSREPNV
N548	EsLSREPNVPMPDRD
K573	EETTDPKKPTTDEGT
K642-u	MEFVEYNkQQLSRIY
S735-p	ALRVKVIsGQFLSDK
Y747	SDKKVGIYVEVDMFG
K805-u	AAFEEGGkFVGHRIL
S815	GHRILPVSAIRSGYH
Y848	IYTEASDYIPDDHQD
Y856-p	IPDDHQDyAEALINP
T925	PRWPPGPTTSSTSSS
S932	TTSSTSSSLSSPGQR
S935	STSSSLSSPGQRDDL
K1029	VKEEEEAKQYREFQN
Y1031	EEEEAKQYREFQNRQ
K1081	DTHTTQFKRLKELNE
S1105-p	LDRKRNNsIsEAKTR
S1107-p	RKRNNsIsEAKTREK
T1122	HKKEVELTEINRRHI
T1130	EINRRHITESVNSIR

	rat
S26-p	VETLRRGsKFIKWDE
K82	GRYARLPKDPKIREV
Y277	ARLLIEKYEPNKQFL
K281	IEKYEPNKQFLERDQ
Y426	QQAKMAEYCRSIFGE
Y443-p	LIDPLDKyPLsAGtP
S446-p	PLDKyPLsAGtPLPs
T449-p	KyPLsAGtPLPsPQD
S453-p	sAGtPLPsPQDLMGR
S472	NKKRHRPSTGVPDSS
T473	KKRHRPSTGVPDSSV
S479	STGVPDSSVAKRPLE
S490	RPLEQSNSALSESSA
S535-p	TSLEPQKsLGEEGLN
G540	QKsLGEEGLNRGPNV
N546	EGLNRGPNVLMPDRD
K571	EETTDPKKPTTDEGT
K640	MEFVEYNKQQLSRIY
S733	ALRVKVISGQFLSDR
Y745	SDRKVGIYVEVDMFG
R803	AAFEEGGRFVGHRIL
S813	GHRILPVSAIRSGYH
Y846	IYTEASDYIPDDHQD
Y854	IPDDHQDYAEALINP
T923	PRWPPGPTTSPTSTS
S930	TTSPTSTSLSSPGQR
S933	PTSTSLSSPGQRDDL
R1029	EEEKEAARQYREFQN
Y1031	EKEAARQYREFQNRQ
K1081	DAHTTQFKRLKELNE
S1105-p	LDRKRNNsISEAKTR
S1107	RKRNNsISEAKTREK
T1122	HKKEVELTEINRRHI
T1130	EINRRHITESVNSIR

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