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Protein Page:
ATG5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG5 Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: membrane; pre-autophagosomal structure membrane; cytoplasm; autophagic vacuole; axoneme
Molecular Function: protein binding
Biological Process: response to drug; response to fungus; apoptosis; ventricular cardiac muscle cell development; post-translational protein modification; vasodilation; heart contraction; regulation of cytokine secretion during immune response; autophagy; innate immune response; negative regulation of protein ubiquitination; blood vessel remodeling; negative regulation of interferon type I production; otolith development; autophagic vacuole formation; negative regulation of apoptosis
Reference #:  Q9H1Y0 (UniProtKB)
Alt. Names/Synonyms: APG5; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like; APG5-like; APG5L; apoptosis specific protein; Apoptosis-specific protein; ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae); ATG5 autophagy related 5-like; Autophagy protein 5; hAPG5
Gene Symbols: ATG5
Molecular weight: 32,447 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y35-p TEREAEPyYLLLPRV
0 6 Y44 LLLPRVSYLTLVTDK
1 0 T75 IWFEYEGTPLKWHyP
0 1 Y81-p GTPLKWHyPIGLLFD
0 1 T101-p SALPWNItVHFKSFP
0 2 K138-ub EADALKHkSQVINEM
0 1 K171-ub QFWAINRkLMEYPAE
  mouse

 
Y35 TEREAEPYYLLLPRV
Y44-p LLLPRVSyLTLVTDK
T75-p IWFEYEGtPLKWHYP
Y81 GtPLKWHYPIGLLFD
T101 SALPWNITVHFKSFP
K138-ub EADALKHkSQVINEM
K171 QFWAINRKLMEYPPE
  rat

 
Y35 TEREAEPYYLLLPRV
Y44 LLLPRVSYLTLVTDK
T75 IWFEYEGTPLKWHYP
Y81 GTPLKWHYPIGLLFD
T101 SALPWNITVHFKSFP
K138 EADALKHKSQVINEM
K171 QFWTINRKLMEYPPE
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