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ATG5 (human)

Overview ATG5 Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Ubiquitin conjugating system; Autophagy Cellular Component: protein complex; pre-autophagosomal structure membrane; cytoplasm; autophagic vacuole Molecular Function: protein binding Biological Process: response to drug; apoptosis; ventricular cardiac muscle cell development; post-translational protein modification; vasodilation; heart contraction; autophagy; innate immune response; negative regulation of protein ubiquitination; blood vessel remodeling; negative regulation of interferon type I production; otolith development; negative regulation of apoptosis; autophagic vacuole formation Reference #:  Q9H1Y0 (UniProtKB) Alt. Names/Synonyms: APG5; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like; APG5-like; APG5L; apoptosis specific protein; Apoptosis-specific protein; ASP; ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae); ATG5 autophagy related 5-like; Autophagy protein 5; hAPG5 Gene Symbols: ATG5 Molecular weight: 32,447 Da Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG5 4GDK - F/C=11-43 (human) 4GDL - C=11-43 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y35-p	TEREAEPyYLLLPRV
0	6		Y44	LLLPRVSYLTLVTDK
1	0		T75	IWFEYEGTPLKWHyP
0	1		Y81-p	GTPLKWHyPIGLLFD
0	1		T101-p	SALPWNItVHFKSFP
0	2		K138-u	EADALKHkSQVINEM
0	1		K171-u	QFWAINRkLMEYPAE

	mouse
Y35	TEREAEPYYLLLPRV
Y44-p	LLLPRVSyLTLVTDK
T75-p	IWFEYEGtPLKWHYP
Y81	GtPLKWHYPIGLLFD
T101	SALPWNITVHFKSFP
K138-u	EADALKHkSQVINEM
K171	QFWAINRKLMEYPPE

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