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HNRPLL (human)

Overview HNRPLL RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Unknown function Cellular Component: nucleus; ribonucleoprotein complex Molecular Function: mRNA binding; protein binding; nucleotide binding Biological Process: mRNA processing; positive regulation of RNA splicing Reference #:  Q8WVV9 (UniProtKB) Alt. Names/Synonyms: Heterogeneous nuclear ribonucleoprotein L-like; HNRLL; hnRNPLL; HNRPLL; SRRF; stromal RNA regulating factor; Stromal RNA-regulating factor Gene Symbols: HNRPLL Molecular weight: 60,083 Da Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HNRPLL 1WEX - A=116-207 (mouse) 2E5I - A=197-316 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	1		-	gap
0	1		S2	______MSSSSSSPR
0	1		S3	_____MSSSSSSPRE
0	2		S4	____MSSSSSSPRET
0	2		S5	___MSSSSSSPRETY
0	1		S7	_MSSSSSSPRETYEE
0	1		T11	SSSSPRETYEEDREy
0	4		Y18-p	TYEEDREyESQAKRL
0	1		S20	EEDREyESQAKRLKT
0	1		Y34-p	TEEGEIDysAEEGEN
0	9		S35-p	EEGEIDysAEEGENR
0	4		T46-p	GENRREAtPRGGGDG
0	1		-	gap
0	2		S59-p	DGGGGGRsFsQPEAG
0	12		S61-p	GGGGRsFsQPEAGGs
0	5		S68-p	sQPEAGGsHHkVSVS
0	1		K71-u	EAGGsHHkVSVSPVV
0	1		K261-u	NDSWDYTkPYLGRRD
0	1		S284-p	AILGEHPsSFRHDGY
0	1		S308-p	PSRYRMGsRDTPELV
0	1		S323-p	AYPLPQAsSSYMHGG
0	1		K434	YKDFAMSKNNRFTSA
0	1		E504	LSGLLEWECKTDAVE
0	3		Y530-p	VPNGSNPyTLKLCFS
0	1		-	gap

	mouse ► Hide Isoforms
S29-p	DKGKRPLsPRSLLSH
S81-p	VSTAAAMsssssSsP
S82-p	STAAAMsssssSsPK
S83-p	TAAAMsssssSsPKE
S84-p	AAAMsssssSsPKEE
S85-p	AAMsssssSsPKEEt
S87-p	MsssssSsPKEEtYE
T92-p	sSsPKEEtYEEDREF
F99	tYEEDREFEsQAKRL
S101-p	EEDREFEsQAKRLKT
Y115	TEEGEIVYsAEESEN
S116-p	EEGEIVYsAEESENR
T127	SENRQEATPQAGSDs
S134-p	TPQAGSDsDSGGGDG
S186	GSGGGPRSMPLSTEG
P188	GGGPRSMPLSTEGGG
S196	LSTEGGGSHHKVSVS
K199	EGGGSHHKVSVSPVV
K389	NDSWDYTKPYLGRRD
S412	AILGDHPSSFRHDGY
S436	PSRYRMGSRDTPELV
S451	AYPLPQASSSYMHGG
K562-u	YKDFAMSkNNRFTSA
K632-u	LSGLLEWkCKTDAVE
Y658-p	VPNGSNPyTLKLCFS
-	gap

	HNRPLL iso5
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
-	under review
-	gap
S64-p	YVYVVFHsSASFENF

	rat
-	gap
-	gap
S2	______MSSTSSSPK
S3	_____MSSTSSSPKE
T4	____MSSTSSSPKEE
S5	___MSSTSSSPKEET
S7	_MSSTSSSPKEETYE
T12	SSSPKEETYEEDREF
F19	TYEEDREFESQAKRL
S21	EEDREFESQAKRLKT
Y35	TEEGEIVYSAEESEN
S36	EEGEIVYSAEESENR
T47	SENRQEATPQAGSDS
S54	TPQAGSDSDSGGGDR
S107	GSGGGPRSMPPSTEG
P109	GGGPRSMPPSTEGGG
S117	PSTEGGGSHHKVSVS
K120	EGGGSHHKVSVSPVV
K310	NDSWDYTKPYLGRRD
S333	AILGDHPSSFRHDGY
S357	PSRYRMGSRDTPELV
S372	AYPLPQASSSYMHGG
K483	YKDFAMSKNNRFTSA
K553	LSGLLEWKCKTDAVE
Y579	VPNGSNPYTLKLCFS
-	gap

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