EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hormone; Membrane protein, integral; Ligand, receptor tyrosine kinase
Cellular Component: extracellular space; lysosomal membrane; plasma membrane; extracellular region; integral to membrane
Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activator activity; growth factor activity; calcium ion binding; epidermal growth factor receptor binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase activation (dimerization); positive regulation of mitosis; nerve growth factor receptor signaling pathway; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; signal transduction; positive regulation of MAP kinase activity; platelet degranulation; positive regulation of epidermal growth factor receptor activity; branching morphogenesis of a tube; positive regulation of cell proliferation; innate immune response; negative regulation of secretion; angiogenesis; DNA replication; blood coagulation; positive regulation of phosphorylation; positive regulation of DNA binding; positive regulation of granule cell precursor proliferation; STAT protein nuclear translocation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.