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HNRPLL (mouse)

Overview HNRPLL RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Unknown function Cellular Component: ribonucleoprotein complex; nucleus Molecular Function: mRNA binding; nucleic acid binding; RNA binding; nucleotide binding Biological Process: mRNA processing; positive regulation of RNA splicing Reference #:  BAE27500 (GenPept) Alt. Names/Synonyms: 2510028H02Rik; 2810036L13Rik; AI256697; AI852082; Heterogeneous nuclear ribonucleoprotein L-like; HNRLL; Hnrpll Gene Symbols: Hnrpll Molecular weight: 72,196 Da Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HNRPLL 1WEX - A=116-207 (mouse) 2E5I - A=197-316 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1WEX 2E5I  |  Phospho3D  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse ► Hide Isoforms
0	1		S29-p	DKGKRPLsPRSLLSH
0	1		S81-p	VSTAAAMsssssSsP
0	1		S82-p	STAAAMsssssSsPK
0	1		S83-p	TAAAMsssssSsPKE
0	2		S84-p	AAAMsssssSsPKEE
0	2		S85-p	AAMsssssSsPKEEt
0	1		S87-p	MsssssSsPKEEtYE
0	1		T92-p	sSsPKEEtYEEDREF
0	4		F99	tYEEDREFEsQAKRL
0	1		S101-p	EEDREFEsQAKRLKT
0	1		Y115	TEEGEIVYsAEESEN
0	10		S116-p	EEGEIVYsAEESENR
0	4		T127	SENRQEATPQAGSDs
0	1		S134-p	TPQAGSDsDSGGGDG
0	2		S186	GSGGGPRSMPLSTEG
0	12		P188	GGGPRSMPLSTEGGG
0	5		S196	LSTEGGGSHHKVSVS
0	1		K199	EGGGSHHKVSVSPVV
0	1		K389	NDSWDYTKPYLGRRD
0	1		S412	AILGDHPSSFRHDGY
0	1		S436	PSRYRMGSRDTPELV
0	1		S451	AYPLPQASSSYMHGG
0	1		K562-u	YKDFAMSkNNRFTSA
0	1		K632-u	LSGLLEWkCKTDAVE
0	3		Y658-p	VPNGSNPyTLKLCFS
0	1		-	gap

	HNRPLL iso5
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
-	under review
-	gap
S64-p	YVYVVFHsSASFENF

	human
-	gap
-	gap
S2	______MSSSSSSPR
S3	_____MSSSSSSPRE
S4	____MSSSSSSPRET
S5	___MSSSSSSPRETY
S7	_MSSSSSSPRETYEE
T11	SSSSPRETYEEDREy
Y18-p	TYEEDREyESQAKRL
S20	EEDREyESQAKRLKT
Y34-p	TEEGEIDysAEEGEN
S35-p	EEGEIDysAEEGENR
T46-p	GENRREAtPRGGGDG
-	gap
S59-p	DGGGGGRsFsQPEAG
S61-p	GGGGRsFsQPEAGGs
S68-p	sQPEAGGsHHkVSVS
K71-u	EAGGsHHkVSVSPVV
K261-u	NDSWDYTkPYLGRRD
S284-p	AILGEHPsSFRHDGY
S308-p	PSRYRMGsRDTPELV
S323-p	AYPLPQAsSSYMHGG
K434	YKDFAMSKNNRFTSA
E504	LSGLLEWECKTDAVE
Y530-p	VPNGSNPyTLKLCFS
-	gap

	rat
-	gap
-	gap
S2	______MSSTSSSPK
S3	_____MSSTSSSPKE
T4	____MSSTSSSPKEE
S5	___MSSTSSSPKEET
S7	_MSSTSSSPKEETYE
T12	SSSPKEETYEEDREF
F19	TYEEDREFESQAKRL
S21	EEDREFESQAKRLKT
Y35	TEEGEIVYSAEESEN
S36	EEGEIVYSAEESENR
T47	SENRQEATPQAGSDS
S54	TPQAGSDSDSGGGDR
S107	GSGGGPRSMPPSTEG
P109	GGGPRSMPPSTEGGG
S117	PSTEGGGSHHKVSVS
K120	EGGGSHHKVSVSPVV
K310	NDSWDYTKPYLGRRD
S333	AILGDHPSSFRHDGY
S357	PSRYRMGSRDTPELV
S372	AYPLPQASSSYMHGG
K483	YKDFAMSKNNRFTSA
K553	LSGLLEWKCKTDAVE
Y579	VPNGSNPYTLKLCFS
-	gap

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