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Protein Page:
TDP43 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TDP43 DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: nucleolus; nucleus
Molecular Function: identical protein binding; protein binding; mRNA 3'-UTR binding; RNA binding; double-stranded DNA binding; nucleotide binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cell death; regulation of transcription, DNA-dependent; RNA splicing; mRNA processing
Reference #:  Q13148 (UniProtKB)
Alt. Names/Synonyms: ALS10; TADBP; TAR DNA binding protein; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TARDBP; TDP-43; TDP43
Gene Symbols: TARDBP
Molecular weight: 44,740 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TDP43

Protein Structure Not Found.


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Sites Implicated In
autophagy, altered: S409‑p, S410‑p
intracellular localization: S409‑p, S410‑p
molecular association, regulation: S409‑p, S410‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S2-p ______MsEyIRVTE
1 0 Y4-p ____MsEyIRVTEDE
1 0 T25-p IPSEDDGtVLLSTVT
0 2 S48-p LRYRNPVsQCMRGVR
0 1 Y73 AGWGNLVYVVNYPKD
0 3 K84-ub YPKDNKRkMDEtDAs
1 1 T88-p NKRkMDEtDAssAVk
0 1 D89 KRkMDEtDAssAVkV
1 1 S91-p kMDEtDAssAVkVKR
1 1 S92-p MDEtDAssAVkVKRA
0 1 K95-ac tDAssAVkVKRAVQk
0 8 K95-ub tDAssAVkVKRAVQk
0 36 K102-ub kVKRAVQkTSDLIVL
0 1 K114 IVLGLPWKTtEQDLk
0 64 K114-ub IVLGLPWkTtEQDLk
1 0 T116-p LGLPWkTtEQDLkEY
0 1 K121 kTtEQDLKEYFSTFG
0 11 K121-ub kTtEQDLkEYFSTFG
0 1 K136-ac EVLMVQVkKDLkTGH
0 1 K137 VLMVQVkKDLkTGHS
0 1 K140-ac VQVkKDLkTGHSkGF
0 7 K140-ub VQVkKDLkTGHSkGF
0 50 K145-ub DLkTGHSkGFGFVRF
0 15 Y155-p GFVRFTEyETQVkVM
0 33 K160-ub TEyETQVkVMSQRHM
0 44 K176-ub DGRWCDCkLPNSkQs
0 59 K181-ub DCkLPNSkQsQDEPL
1 14 S183-p kLPNSkQsQDEPLRS
0 17 K192-ub DEPLRSRkVFVGRCT
0 2 K224-ub VMDVFIPkPFRAFAF
0 6 Q238 FVTFADDQIAQsLCG
1 0 S242-p ADDQIAQsLCGEDLI
1 0 S254-p DLIIKGIsVHISNAE
0 25 K263-ub HISNAEPkHNSNRQL
0 1 S266 NAEPkHNSNRQLERs
1 1 S273-p SNRQLERsGRFGGNP
1 6 S292-p NQGGFGNsrGGGAGL
0 21 R293-m1 QGGFGNsrGGGAGLG
1 0 S305-p GLGNNQGsNMGGGMN
1 0 S342-p GMMGMLAsQQNQsGP
1 0 S347-p LAsQQNQsGPsGNNQ
1 0 S350-p QQNQsGPsGNNQNQG
1 0 S369-p EPNQAFGsGNNSYsG
1 0 S375-p GsGNNSYsGsNsGAA
1 0 S377-p GNNSYsGsNsGAAIG
3 1 S379-p NSYsGsNsGAAIGWG
1 1 S387-p GAAIGWGsAsNAGsG
1 1 S389-p AIGWGsAsNAGsGsG
1 1 S393-p GsAsNAGsGsGFNGG
1 1 S395-p AsNAGsGsGFNGGFG
6 1 S403-p GFNGGFGssMDsKss
6 0 S404-p FNGGFGssMDsKssG
1 0 S407-p GFGssMDsKssGWGM
22 1 S409-p GssMDsKssGWGM__
22 1 S410-p ssMDsKssGWGM___
  mouse

 
S2 ______MSEYIRVTE
Y4 ____MSEYIRVTEDE
T25 IPSEDDGTVLLSTVT
S48 LRYRNPVSQCMRGVR
Y73 AGWGNLVYVVNYPKD
K84 YPKDNKRKMDETdAS
T88 NKRKMDETdASSAVk
D89-ca KRKMDETdASSAVkV
S91 KMDETdASSAVkVKR
S92 MDETdASSAVkVKRA
K95 TdASSAVKVKRAVQk
K95-ub TdASSAVkVKRAVQk
K102-ub kVKRAVQkTSDLIVL
K114-ac IVLGLPWkTTEQDLk
K114-ub IVLGLPWkTTEQDLk
T116 LGLPWkTTEQDLkDY
K121-ac kTTEQDLkDYFSTFG
K121 kTTEQDLKDYFSTFG
K136 EVLMVQVKkDLKTGH
K137-ac VLMVQVKkDLKTGHS
K140 VQVKkDLKTGHSKGF
K140 VQVKkDLKTGHSKGF
K145 DLKTGHSKGFGFVRF
Y155-p GFVRFTEyETQVkVM
K160-ub TEyETQVkVMSQRHM
K176-ub DGRWCDCkLPNSkQs
K181-ub DCkLPNSkQsPDEPL
S183-p kLPNSkQsPDEPLRS
K192 DEPLRSRKVFVGRCT
K224 VVDVFIPKPFRAFAF
K238-ub FVTFADDkVAQSLCG
S242 ADDkVAQSLCGEDLI
S254 DLIIKGISVHISNAE
K263 HISNAEPKHNsNRQL
S266-p NAEPKHNsNRQLERS
S273 sNRQLERSGRFGGNP
S292-p NQGGFGNsrGGGAGL
R293-m1 QGGFGNsrGGGAGLG
G305 GLGNNQGGNMGGGMN
S342 GMMGMLASQQNQSGP
S347 LASQQNQSGPSGNNQ
S350 QQNQSGPSGNNQSQG
S369 EPNQAFGSGNNSYSG
S375 GSGNNSYSGSNsGAP
S377 GNNSYSGSNsGAPLG
S379-p NSYSGSNsGAPLGWG
S387-p GAPLGWGsAsNAGsG
S389-p PLGWGsAsNAGsGsG
S393-p GsAsNAGsGsGFNGG
S395-p AsNAGsGsGFNGGFG
S403-p GFNGGFGsSMDSKss
S404 FNGGFGsSMDSKssG
S407 GFGsSMDSKssGWGM
S409-p GsSMDSKssGWGM__
S410-p sSMDSKssGWGM___
  rat

 
S2 ______MSEYIRVTE
Y4 ____MSEYIRVTEDE
T25 IPSEDDGTVLLSTVT
S48 LRYRNPVSQCMRGVR
Y73-p AGWGNLVyVVNYPKD
K84 YPKDNKRKMDEADAS
A88 NKRKMDEADASSAVK
D89 KRKMDEADASSAVKV
S91 KMDEADASSAVKVKR
S92 MDEADASSAVKVKRA
K95 ADASSAVKVKRAVQK
K95 ADASSAVKVKRAVQK
K102 KVKRAVQKTSDLIVL
K114 IVLGLPWKTTEQDLK
K114 IVLGLPWKTTEQDLK
T116 LGLPWKTTEQDLKDY
K121 KTTEQDLKDYFSTFG
K121 KTTEQDLKDYFSTFG
K136 EVLMVQVKKDLKTGH
K137 VLMVQVKKDLKTGHS
K140 VQVKKDLKTGHSkGF
K140 VQVKKDLKTGHSkGF
K145-ub DLKTGHSkGFGFVRF
Y155 GFVRFTEYETQVKVM
K160 TEYETQVKVMSQRHM
K176-ub DGRWCDCkLPNSkQs
K181-ub DCkLPNSkQsPDEPL
S183-p kLPNSkQsPDEPLRS
K192 DEPLRSRKVFVGRCT
K224 VVDVFIPKPFRAFAF
K238-ub FVTFADDkVAQSLCG
S242 ADDkVAQSLCGEDLI
S254 DLIIKGISVHISNAE
K263 HISNAEPKHNSNRQL
S266 NAEPKHNSNRQLERS
S273 SNRQLERSGRFGGKS
S285 GKSPFGRS_______
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