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Protein Page:
TARDBP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TARDBP DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: nucleoplasm; perichromatin fibrils; cytoplasm; nuclear speck; nucleus
Molecular Function: identical protein binding; protein binding; mRNA 3'-UTR binding; RNA binding; double-stranded DNA binding; nucleotide binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; RNA splicing; positive regulation of insulin secretion; positive regulation of transcription from RNA polymerase II promoter; mRNA processing
Disease: Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia
Reference #:  Q13148 (UniProtKB)
Alt. Names/Synonyms: ALS10; TADBP; TAR DNA binding protein; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TARDBP; TDP-43; TDP43
Gene Symbols: TARDBP
Molecular weight: 44,740 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TARDBP

Protein Structure Not Found.


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Sites Implicated In
autophagy, altered: S409‑p, S410‑p
intracellular localization: S409‑p, S410‑p
molecular association, regulation: S409‑p, S410‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 S2-p ______MsEyIRVTE
1 0 Y4-p ____MsEyIRVTEDE
1 0 T25-p IPSEDDGtVLLSTVT
0 2 S48-p LRYRNPVsQCMRGVR
0 1 Y73 AGWGNLVYVVNYPKD
0 3 K84-ub YPKDNKRkMDEtDAs
1 1 T88-p NKRkMDEtDAssAVk
0 1 D89 KRkMDEtDAssAVkV
1 1 S91-p kMDEtDAssAVkVKR
1 1 S92-p MDEtDAssAVkVKRA
0 1 K95-ac tDAssAVkVKRAVQk
0 8 K95-ub tDAssAVkVKRAVQk
0 36 K102-ub kVKRAVQkTSDLIVL
0 1 K114 IVLGLPWKTtEQDLk
0 64 K114-ub IVLGLPWkTtEQDLk
1 0 T116-p LGLPWkTtEQDLkEY
0 1 K121 kTtEQDLKEYFSTFG
0 11 K121-ub kTtEQDLkEYFSTFG
0 1 K136-ac EVLMVQVkKDLkTGH
0 1 K137 VLMVQVkKDLkTGHS
0 1 K140-ac VQVkKDLkTGHSkGF
0 7 K140-ub VQVkKDLkTGHSkGF
1 0 K145-ac DLkTGHSkGFGFVRF
0 50 K145-ub DLkTGHSkGFGFVRF
0 15 Y155-p GFVRFTEyETQVkVM
0 33 K160-ub TEyETQVkVMSQRHM
0 44 K176-ub DGRWCDCkLPNSkQs
0 59 K181-ub DCkLPNSkQsQDEPL
1 16 S183-p kLPNSkQsQDEPLRS
1 0 K192-ac DEPLRSRkVFVGRCT
0 17 K192-ub DEPLRSRkVFVGRCT
0 2 K224-ub VMDVFIPkPFRAFAF
0 6 Q238 FVTFADDQIAQsLCG
1 0 S242-p ADDQIAQsLCGEDLI
1 0 S254-p DLIIKGIsVHISNAE
0 25 K263-ub HISNAEPkHNSNRQL
0 1 S266 NAEPkHNSNRQLERs
1 2 S273-p SNRQLERsGRFGGNP
1 8 S292-p NQGGFGNsrGGGAGL
0 21 R293-m1 QGGFGNsrGGGAGLG
1 0 S305-p GLGNNQGsNMGGGMN
1 0 S342-p GMMGMLAsQQNQsGP
1 0 S347-p LAsQQNQsGPsGNNQ
1 0 S350-p QQNQsGPsGNNQNQG
1 0 S369-p EPNQAFGsGNNSYsG
1 0 S375-p GsGNNSYsGsNsGAA
1 0 S377-p GNNSYsGsNsGAAIG
3 1 S379-p NSYsGsNsGAAIGWG
1 1 S387-p GAAIGWGsAsNAGsG
1 1 S389-p AIGWGsAsNAGsGsG
1 1 S393-p GsAsNAGsGsGFNGG
1 1 S395-p AsNAGsGsGFNGGFG
6 1 S403-p GFNGGFGssMDsKss
6 0 S404-p FNGGFGssMDsKssG
1 0 S407-p GFGssMDsKssGWGM
23 1 S409-p GssMDsKssGWGM__
23 1 S410-p ssMDsKssGWGM___
  TARDBP iso4  
- gap
- gap
- gap
- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
K18 CMLSTIQKVKKDLKT
- gap
- gap
- gap
- gap
- gap
K20 LSTIQKVKKDLKTGH
K21 STIQKVKKDLKTGHS
K24 QKVKKDLKTGHSKGF
K24 QKVKKDLKTGHSKGF
K29 DLKTGHSKGFGFVRF
K29 DLKTGHSKGFGFVRF
Y39 GFVRFTEYETQVKVM
K44 TEYETQVKVMSQRHM
K60 DGRWCDCKLPNSKQS
K65 DCKLPNSKQSQDEPL
S67 KLPNSKQSQDEPLRS
K76 DEPLRSRKVFVGRCT
K76 DEPLRSRKVFVGRCT
K108 VMDVFIPKPFRAFAF
Q122 FVTFADDQIAQSLCG
S126 ADDQIAQSLCGEDLI
S138 DLIIKGISVHISNAE
K147 HISNAEPKHNSNRQL
S150 NAEPKHNSNRQLERS
S157 SNRQLERSGRFGGNP
S176 NQGGFGNSRGGGAGL
R177 QGGFGNSRGGGAGLG
S189 GLGNNQGSNMGGGMN
S226 GMMGMLASQQNQSGP
S231 LASQQNQSGPSGNNQ
S234 QQNQSGPSGNNQNQG
S253 EPNQAFGSGNNSYSG
S259 GSGNNSYSGSNSGAA
S261 GNNSYSGSNSGAAIG
S263 NSYSGSNSGAAIGWG
S271 GAAIGWGSASNAGSG
S273 AIGWGSASNAGSGSG
S277 GSASNAGSGSGFNGG
S279 ASNAGSGSGFNGGFG
S287 GFNGGFGSSMDSKSS
S288 FNGGFGSSMDSKSSG
S291 GFGSSMDSKSSGWGM
S293 GSSMDSKSSGWGM__
S294 SSMDSKSSGWGM___
  mouse

 
S2 ______MSEYIRVTE
Y4 ____MSEYIRVTEDE
T25 IPSEDDGTVLLSTVT
S48 LRYRNPVSQCMRGVR
Y73 AGWGNLVYVVNYPKD
K84 YPKDNKRKMDETdAS
T88 NKRKMDETdASSAVk
D89-ca KRKMDETdASSAVkV
S91 KMDETdASSAVkVKR
S92 MDETdASSAVkVKRA
K95 TdASSAVKVKRAVQk
K95-ub TdASSAVkVKRAVQk
K102-ub kVKRAVQkTSDLIVL
K114-ac IVLGLPWkTTEQDLk
K114-ub IVLGLPWkTTEQDLk
T116 LGLPWkTTEQDLkDY
K121-ac kTTEQDLkDYFSTFG
K121 kTTEQDLKDYFSTFG
K136 EVLMVQVKkDLKTGH
K137-ac VLMVQVKkDLKTGHS
K140 VQVKkDLKTGHSKGF
K140 VQVKkDLKTGHSKGF
K145 DLKTGHSKGFGFVRF
K145 DLKTGHSKGFGFVRF
Y155-p GFVRFTEyETQVkVM
K160-ub TEyETQVkVMSQRHM
K176-ub DGRWCDCkLPNSkQs
K181-ub DCkLPNSkQsPDEPL
S183-p kLPNSkQsPDEPLRS
K192 DEPLRSRKVFVGRCT
K192 DEPLRSRKVFVGRCT
K224 VVDVFIPKPFRAFAF
K238-ub FVTFADDkVAQSLCG
S242 ADDkVAQSLCGEDLI
S254 DLIIKGISVHISNAE
K263 HISNAEPKHNsNRQL
S266-p NAEPKHNsNRQLERS
S273 sNRQLERSGRFGGNP
S292-p NQGGFGNsrGGGAGL
R293-m1 QGGFGNsrGGGAGLG
G305 GLGNNQGGNMGGGMN
S342 GMMGMLASQQNQSGP
S347 LASQQNQSGPSGNNQ
S350 QQNQSGPSGNNQSQG
S369 EPNQAFGSGNNSYSG
S375 GSGNNSYSGSNsGAP
S377 GNNSYSGSNsGAPLG
S379-p NSYSGSNsGAPLGWG
S387-p GAPLGWGsAsNAGsG
S389-p PLGWGsAsNAGsGsG
S393-p GsAsNAGsGsGFNGG
S395-p AsNAGsGsGFNGGFG
S403-p GFNGGFGsSMDSKss
S404 FNGGFGsSMDSKssG
S407 GFGsSMDSKssGWGM
S409-p GsSMDSKssGWGM__
S410-p sSMDSKssGWGM___
  rat

 
S2 ______MSEYIRVTE
Y4 ____MSEYIRVTEDE
T25 IPSEDDGTVLLSTVT
S48 LRYRNPVSQCMRGVR
Y73-p AGWGNLVyVVNYPKD
K84 YPKDNKRKMDEADAS
A88 NKRKMDEADASSAVK
D89 KRKMDEADASSAVKV
S91 KMDEADASSAVKVKR
S92 MDEADASSAVKVKRA
K95 ADASSAVKVKRAVQK
K95 ADASSAVKVKRAVQK
K102 KVKRAVQKTSDLIVL
K114 IVLGLPWKTTEQDLK
K114 IVLGLPWKTTEQDLK
T116 LGLPWKTTEQDLKDY
K121 KTTEQDLKDYFSTFG
K121 KTTEQDLKDYFSTFG
K136 EVLMVQVKKDLKTGH
K137 VLMVQVKKDLKTGHS
K140 VQVKKDLKTGHSkGF
K140 VQVKKDLKTGHSkGF
K145 DLKTGHSKGFGFVRF
K145-ub DLKTGHSkGFGFVRF
Y155 GFVRFTEYETQVKVM
K160 TEYETQVKVMSQRHM
K176-ub DGRWCDCkLPNSkQs
K181-ub DCkLPNSkQsPDEPL
S183-p kLPNSkQsPDEPLRS
K192 DEPLRSRKVFVGRCT
K192 DEPLRSRKVFVGRCT
K224 VVDVFIPKPFRAFAF
K238-ub FVTFADDkVAQSLCG
S242 ADDkVAQSLCGEDLI
S254 DLIIKGISVHISNAE
K263 HISNAEPKHNSNRQL
S266 NAEPKHNSNRQLERS
S273 SNRQLERSGRFGGKS
S285 GKSPFGRS_______
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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- gap
- gap
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