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PDGFRa (human)

Overview PDGFRa a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; PDGFR family Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus; intrinsic to plasma membrane Molecular Function: vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; phosphoinositide 3-kinase binding; platelet-derived growth factor alpha-receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: estrogen metabolic process; extracellular matrix organization and biogenesis; regulation of chemotaxis; peptidyl-tyrosine phosphorylation; wound healing; protein amino acid autophosphorylation; cardiac myofibril assembly; platelet-derived growth factor receptor signaling pathway; palate development; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; positive regulation of fibroblast proliferation; Leydig cell differentiation; embryonic digestive tract morphogenesis; luteinization; positive regulation of cell proliferation; male genitalia development; inner ear development; response to inorganic substance; phosphoinositide-mediated signaling; in utero embryonic development; adrenal gland development; gliogenesis; positive regulation of phosphoinositide 3-kinase activity; embryonic cranial skeleton morphogenesis; embryonic skeletal morphogenesis; odontogenesis of dentine-containing teeth; positive regulation of phosphoinositide 3-kinase cascade; cell activation; response to hyperoxia; response to cytokine stimulus; virus-host interaction; vascular endothelial growth factor receptor signaling pathway; positive regulation of DNA replication; positive regulation of cell migration; lung development Reference #:  P16234 (UniProtKB) Alt. Names/Synonyms: Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140A; CD140a antigen; MGC74795; PDGF-R-alpha; PDGFR2; PDGFRA; PGFRA; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA Gene Symbols: PDGFRA Molecular weight: 122,670 Da Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDGFRa 1GQ5 - - (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE 173490 606764 607685  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: Y572‑p, Y574‑p, Y720‑p, Y731‑p, Y742‑p, Y754‑p, Y762‑p, Y988‑p, Y1018‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K378-m1	QEIRYRSkLKLIRAK
0	2		S566-p	WRVIESIsPDGHEyI
2	21		Y572-p	IsPDGHEyIyVDPMQ
2	18		Y574-p	PDGHEyIyVDPMQLP
0	8		Y582-p	VDPMQLPyDsRWEFP
0	2		S584-p	PMQLPyDsRWEFPRD
0	1		K606	LGSGAFGKVVEGTAy
0	47		Y613-p	KVVEGTAyGLSRSQP
0	1		K703	HHPEKPKKELDIFGL
0	1		S719	PADESTRSyVILSFE
5	4		Y720-p	ADESTRSyVILSFEN
1	36		Y731-p	SFENNGDyMDMKQAD
0	1		T739-p	MDMKQADttQyVPML
0	4		T740-p	DMKQADttQyVPMLE
1	103		Y742-p	KQADttQyVPMLERK
1	4		S752-p	MLERKEVsKysDIQR
0	1		K753	LERKEVsKysDIQRs
3	37		Y754-p	ERKEVsKysDIQRsL
0	7		S755-p	RKEVsKysDIQRsLy
0	2		S760-p	KysDIQRsLyDRPAs
2	341		Y762-p	sDIQRsLyDRPAsyK
1	9		S767-p	sLyDRPAsyKKKSML
1	280		Y768-p	LyDRPAsyKKKSMLD
0	20		S847-p	ARDIMHDsNyVSKGS
0	61		Y849-p	DIMHDsNyVSKGSTF
0	1		K852	HDsNyVSKGSTFLPV
0	5		Y926-p	DHATSEVyEIMVKCW
0	2		Y944-p	PEKRPSFyHLSEIVE
0	4		Y958-p	ENLLPGQyKKSyEKI
0	5		Y962-p	PGQyKKSyEKIHLDF
0	1		K964	QyKKSyEKIHLDFLK
0	2		K971	KIHLDFLKSDHPAVA
0	2		S984	VARMRVDSDNAyIGV
3	19		Y988-p	RVDSDNAyIGVTyKN
0	2		Y993-p	NAyIGVTyKNEEDKL
0	1		S1013	GLDEQRLSADsGyII
0	3		S1016-p	EQRLSADsGyIIPLP
4	103		Y1018-p	RLSADsGyIIPLPDI
0	1		K1036	PEEEDLGKRNRHssQ
0	1		S1041-p	LGKRNRHssQTSEEs
0	2		S1042-p	GKRNRHssQTSEEsA
0	1		S1048-p	ssQTSEEsAIETGSS
0	1		S1080-p	MDDIGIDssDLVEDs
0	1		S1081-p	DDIGIDssDLVEDsF
0	1		S1087-p	ssDLVEDsFL_____

	mouse
K378	QETRYQSKLKLIRAK
S566-p	WRVIESIsPDGHEyI
Y572-p	IsPDGHEyIyVDPMQ
Y574-p	PDGHEyIyVDPMQLP
Y582-p	VDPMQLPyDSRWEFP
S584	PMQLPyDSRWEFPRD
K606-u	LGSGAFGkVVEGTAy
Y613-p	kVVEGTAyGLSRSQP
K703-u	QHPEKPKkDLDIFGL
S719-p	PADESTRsyVILSFE
Y720-p	ADESTRsyVILSFEN
Y731-p	SFENNGDyMDMKQAD
T739	MDMKQADTTQyVPML
T740	DMKQADTTQyVPMLE
Y742-p	KQADTTQyVPMLERK
S752-p	MLERKEVskysDIQR
K753-u	LERKEVskysDIQRS
Y754-p	ERKEVskysDIQRSL
S755-p	RKEVskysDIQRSLy
S760	kysDIQRSLyDRPAs
Y762-p	sDIQRSLyDRPAsyK
S767-p	SLyDRPAsyKKKSML
Y768-p	LyDRPAsyKKKSMLD
S847-p	ARDIMHDsNyVSkGS
Y849-p	DIMHDsNyVSkGSTF
K852-u	HDsNyVSkGSTFLPV
Y926	DHATSEVYEIMVQCW
Y944	PEKRPSFYHLSEIVE
Y958	ENLLPGQYKKSYEkI
Y962	PGQYKKSYEkIHLDF
K964-u	QYKKSYEkIHLDFLk
K971-u	kIHLDFLkSDHPAVA
S984-p	VARMRVDsDNAyIGV
Y988-p	RVDsDNAyIGVTYKN
Y993	NAyIGVTYKNEEDKL
S1013-p	GLDEQRLsADSGyII
S1016	EQRLsADSGyIIPLP
Y1018-p	RLsADSGyIIPLPDI
K1036-u	PEEEDLGkRNRHSSQ
S1041	LGkRNRHSSQTSEES
S1042	GkRNRHSSQTSEESA
S1048	SSQTSEESAIETGSS
S1080	MDDIGIDSSDLVEDS
S1081	DDIGIDSSDLVEDSF
S1087	SSDLVEDSFL_____

	rat
K377	QETRYQSKLKLIRAK
S565	WRVIESISPDGHEYI
Y571	ISPDGHEYIYVDPMQ
Y573	PDGHEYIYVDPMQLP
Y581	VDPMQLPYDSRWEFP
S583	PMQLPYDSRWEFPRD
K605	LGSGAFGKVVEGTAy
Y612-p	KVVEGTAyGLSRSQP
K702	RHPEKPKKDLDIFGL
S718	PADESTRSYVILSFE
Y719	ADESTRSYVILSFEN
Y730-p	SFENNGDyVDMKQAD
T738	VDMKQADTTQYVPML
T739	DMKQADTTQYVPMLE
Y741	KQADTTQYVPMLERK
S751-p	MLERKEVsKYSDIQR
K752	LERKEVsKYSDIQRS
Y753	ERKEVsKYSDIQRSL
S754	RKEVsKYSDIQRSLY
S759	KYSDIQRSLYDRPAS
Y761	SDIQRSLYDRPASYK
S766	SLYDRPASYKKKSML
Y767	LYDRPASYKKKSMLD
S846	ARDIMHDSNYVSKGS
Y848	DIMHDSNYVSKGSTF
K851	HDSNYVSKGSTFLPV
Y925	DHATSEVYEIMVQCW
Y943	PEKRPSFYHLSEIVE
Y957	ENLLPGQYKKSYEKI
Y961	PGQYKKSYEKIHLDF
K963	QYKKSYEKIHLDFLK
K970	KIHLDFLKSDHPAVA
S983	VARMRVDSDNAYIGV
Y987	RVDSDNAYIGVTYKN
Y992	NAYIGVTYKNEEDKL
S1012	GLDEQRLSADSGYII
S1015	EQRLSADSGYIIPLP
Y1017	RLSADSGYIIPLPDI
K1035	PEEEDLGKRNRHSSQ
S1040	LGKRNRHSSQTSEES
S1041	GKRNRHSSQTSEESA
S1047	SSQTSEESAIETGSS
S1079	MDDIGIDSSDLVEDS
S1080	DDIGIDSSDLVEDSF
S1086	SSDLVEDSFL_____

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