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Protein Page:
AGPAT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AGPAT2 Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1); also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - ether lipid; Transferase; Lipid Metabolism - glycerolipid; Membrane protein, integral; EC 2.3.1.51; Lipid Metabolism - glycerophospholipid; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity
Biological Process: positive regulation of cytokine production; epidermis development; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; CDP-diacylglycerol biosynthetic process; positive regulation of cytokine and chemokine mediated signaling pathway
Reference #:  O15120 (UniProtKB)
Alt. Names/Synonyms: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta); 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase-beta); 1-AGP acyltransferase 2; 1-AGPAT 2; 1-AGPAT2; AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta; Lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta; PLCB
Gene Symbols: AGPAT2
Molecular weight: 30,914 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Select Structure to View Below

AGPAT2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y72-p WFVRSFKyFyGLRFE
0 1 Y74-p VRSFKyFyGLRFEVR
0 4 R84 RFEVRDPRRLQEARP
0 2 R85 FEVRDPRRLQEARPC
0 6 K120 ERCVQIAKRELLFLG
0 3 K166-ub RMVRENLkVWIYPEG
0 7 K185 NGDLLPFKKGAFYLA
0 1 K185-ub NGDLLPFkKGAFYLA
0 1 K216 SFYNTKKKFFTsGTV
0 1 S220-p TKKKFFTsGTVTVQV
0 1 T233-p QVLEAIPtsGLtAAD
0 1 S234-p VLEAIPtsGLtAADV
0 1 T237-p AIPtsGLtAADVPAL
0 1 H249 PALVDTCHRAMRTTF
0 1 T255 CHRAMRTTFLHISkt
0 1 S260 RTTFLHISktPQENG
0 1 K261-ub TTFLHISktPQENGA
0 1 T262-p TFLHISktPQENGAT
0 1 A270 PQENGATAGsGVQPA
0 1 S272-p ENGATAGsGVQPAQ_
  mouse

 
Y72 WFVRSFKYVYGLRFE
Y74 VRSFKYVYGLRFEVS
K84-ac RFEVSGQkkLEVDGP
K85-ac FEVSGQkkLEVDGPC
K120-ac KRCVQIAkRELMFTG
K166-ub LMVKENLkVWIYPEG
K185-ac NGDLLPFkKGAFYLA
K185 NGDLLPFKKGAFYLA
K216-ub SFYNVKTkLFTSGTI
S220 VKTkLFTSGTIKVQV
T233 QVLDAVPTNGLTDAD
N234 VLDAVPTNGLTDADV
T237 AVPTNGLTDADVTKL
Y249-p TKLVDTCyQSMRAtF
T255-p CyQSMRAtFLQIsQI
S260-p RAtFLQIsQIPQENS
Q261 AtFLQIsQIPQENSA
I262 tFLQIsQIPQENSAI
K270-ub PQENSAIkEPGVLPA
P272 ENSAIkEPGVLPAQ_
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