a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
Biological Process: positive regulation of MAP kinase activity; negative regulation of T cell proliferation; regulation of cGMP metabolic process; cGMP catabolic process; signal transduction; blood coagulation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.