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Protein Page:
PDE5A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PDE5A a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.35; EC 3.1.4.17; Phosphodiesterase; Nucleotide Metabolism - purine
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
Biological Process: positive regulation of MAP kinase activity; negative regulation of T cell proliferation; cGMP catabolic process; signal transduction; blood coagulation
Reference #:  O76074 (UniProtKB)
Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; CN5A; PDE5; PDE5A; PDE5A1; phosphodiesterase 5A, cGMP-specific
Gene Symbols: PDE5A
Molecular weight: 99,985 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDE5A

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S102‑p
molecular association, regulation: S102‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S86-p CSCPLQQsPRADNsA
0 1 S92-p QsPRADNsAPGTPTR
6 1 S102-p GTPTRKIsASEFDRP
0 3 T137-p KKEQMPLtPPRFDHD
0 1 K714-u EEYKTTLkIIKQAIL
  mouse

 
S76 CSCSLQQSPHADNTT
T82 QSPHADNTTPGAPAR
S92-p GAPARKIsASEFDRP
T127-p KKEQMPLtPPRFDSD
K704 DEYKTTLKIIKQAIL
  rat

 
S44 CSCSLPQSPHADNTT
T50 QSPHADNTTPGAPAR
S60 GAPARKISASEFDRP
T95 KKEQMPLTSPRFDSD
K672 EEYKTTLKIIKQAIL
  cow

 
S76 CSCPLQPSPRAESSV
S82 PSPRAESSVPGTPTR
S92-p GTPTRKIsASEFDRP
T127 KKEQMPLTSPRFDND
K704 EEYKTTLKIIKQAIL
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