a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms. Note: This description may include information from UniProtKB.
Biological Process: nervous system development; cyclic nucleotide metabolic process; positive regulation of chronic inflammatory response; short-term memory; positive regulation of apoptosis; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; vasodilation; positive regulation of MAP kinase activity; negative regulation of T cell proliferation; response to hypoxia; positive regulation of vasoconstriction; cGMP catabolic process; blood coagulation; regulation of the force of heart contraction
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.