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PDE5A (human)

Overview PDE5A a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms. Note: This description may include information from UniProtKB. Protein type: Phosphodiesterase; EC 3.1.4.35; Nucleotide Metabolism - purine; EC 3.1.4.17 Cellular Component: cytosol Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; zinc ion binding; cGMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity Biological Process: nervous system development; cyclic nucleotide metabolic process; positive regulation of chronic inflammatory response; short-term memory; positive regulation of apoptosis; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; vasodilation; positive regulation of MAP kinase activity; negative regulation of T cell proliferation; response to hypoxia; positive regulation of vasoconstriction; cGMP catabolic process; blood coagulation; regulation of the force of heart contraction Reference #:  O76074 (UniProtKB) Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; CN5A; PDE5; PDE5A; PDE5A1; phosphodiesterase 5A, cGMP-specific Gene Symbols: PDE5A Molecular weight: 99,985 Da Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDE5A 1RKP - A=535-860 (human) 1T9R - A=529-875 (human) 1T9S - A/B=534-858 (human) 1TBF - A=534-858 (human) 1UDT - A=537-860 (human) 1UDU - A/B=537-860 (human) 1UHO - A=537-860 (human) 1XOZ - A=534-875 (human) 1XP0 - A=534-875 (human) 2CHM - A=534-858 (human) 2H40 - A=535-860 (human) 2H42 - A/B/C=535-860 (human) 2H44 - A=535-860 (human) 2XSS - A/B=346-509 (human) 3B2R - A/B=535-860 (human) 3BJC - A=1-875 (human) 3HC8 - A=682-858 (human) 3HDZ - A=682-858 (human) 3JWQ - A/D/C/B=827-860 (human) 3JWR - A/B=827-860 (human) 3LFV - A/B=98-518 (human) 3MF0 - A/B=89-518 (human) 3SHY - A=535-860 (human) 3SHZ - A=535-860 (human) 3SIE - A/B=535-860 (human) 3TGE - A=682-858 (human) 3TGG - A=534-858 (human) 3TSE - A=535-860 (human) 3TSF - A=535-860 (human) 1FL4 - A=118-309 (cow)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 3TSE 3TSF  |  ENZYME 3.1.4.17 3.1.4.35  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
enzymatic activity, induced: S102‑p molecular association, regulation: S102‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S86-p	CSCPLQQsPRADNsA
0	1		S92-p	QsPRADNsAPGTPTR
6	0		S102-p	GTPTRKIsASEFDRP
0	1		S118	RPIVVKDSEGTVSFL
0	1		T121	VVKDSEGTVSFLSDS
0	2		T137-p	KKEQMPLtPPRFDHD
0	1		K714-u	EEYKTTLkIIKQAIL
0	1		S869-p	KMLINGEsGQAKRN_

	mouse
S76	CSCSLQQSPHADNTT
T82	QSPHADNTTPGAPAR
S92-p	GAPARKIsASEFDRP
S108-p	RPIVVKDsEGtVSFL
T111-p	VVKDsEGtVSFLSDS
T127-p	KKEQMPLtPPRFDSD
K704	DEYKTTLKIIKQAIL
S859	KMLLNGESSQGKRD_

	rat
S44	CSCSLPQSPHADNTT
T50	QSPHADNTTPGAPAR
S60	GAPARKISASEFDRP
S76	RPIVVKDSEGTVSFL
T79	VVKDSEGTVSFLSDS
T95	KKEQMPLTSPRFDSD
K672	EEYKTTLKIIKQAIL
S827	KTLLNGESGQAKRD_

	cow
S76	CSCPLQPSPRAESSV
S82	PSPRAESSVPGTPTR
S92-p	GTPTRKIsASEFDRP
S108	RPIVIKDSEGTVSFL
T111	VIKDSEGTVSFLSDS
T127	KKEQMPLTSPRFDND
K704	EEYKTTLKIIKQAIL
S859	KTLINGESSQTKRN_

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