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Protein Page:
PDE5A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDE5A a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; EC 3.1.4.35; Phosphodiesterase
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
Biological Process: positive regulation of MAP kinase activity; negative regulation of T cell proliferation; cGMP catabolic process; blood coagulation; signal transduction
Reference #:  O76074 (UniProtKB)
Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; CN5A; PDE5; PDE5A; PDE5A1; phosphodiesterase 5A, cGMP-specific
Gene Symbols: PDE5A
Molecular weight: 99,985 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PDE5A

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S102‑p
molecular association, regulation: S102‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S86-p CSCPLQQsPRADNsA
0 1 S92-p QsPRADNsAPGTPTR
6 1 S102-p GTPTRKIsASEFDRP
0 1 S118 RPIVVKDSEGTVSFL
0 1 T121 VVKDSEGTVSFLSDS
0 3 T137-p KKEQMPLtPPRFDHD
0 1 K714-ub EEYKTTLkIIKQAIL
0 1 S869-p KMLINGEsGQAKRN_
  mouse

 
S76 CSCSLQQSPHADNTT
T82 QSPHADNTTPGAPAR
S92-p GAPARKIsASEFDRP
S108-p RPIVVKDsEGtVSFL
T111-p VVKDsEGtVSFLSDS
T127-p KKEQMPLtPPRFDSD
K704 DEYKTTLKIIKQAIL
S859 KMLLNGESSQGKRD_
  rat

 
S44 CSCSLPQSPHADNTT
T50 QSPHADNTTPGAPAR
S60 GAPARKISASEFDRP
S76 RPIVVKDSEGTVSFL
T79 VVKDSEGTVSFLSDS
T95 KKEQMPLTSPRFDSD
K672 EEYKTTLKIIKQAIL
S827 KTLLNGESGQAKRD_
  cow

 
S76 CSCPLQPSPRAESSV
S82 PSPRAESSVPGTPTR
S92-p GTPTRKIsASEFDRP
S108 RPIVIKDSEGTVSFL
T111 VIKDSEGTVSFLSDS
T127 KKEQMPLTSPRFDND
K704 EEYKTTLKIIKQAIL
S859 KTLINGESSQTKRN_
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