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Protein Page:
RAB8A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAB8A May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO/C1orf88. Interacts with BIRC6/bruce. Interacts with OCRL. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein; G protein, monomeric, Rab; G protein, monomeric
Cellular Component: Golgi membrane; centrosome; phagocytic vesicle membrane; cytoplasmic vesicle membrane; cell soma; nonmotile primary cilium; recycling endosome membrane; postsynaptic density; dendrite; plasma membrane; phagocytic vesicle; cilium
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein kinase binding; Rab GTPase binding
Biological Process: regulation of protein transport; regulation of long-term neuronal synaptic plasticity; protein transport; Golgi vesicle fusion to target membrane; cellular response to insulin stimulus; axonogenesis; GTP catabolic process; small GTPase mediated signal transduction; cilium biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; vesicle docking during exocytosis
Reference #:  P61006 (UniProtKB)
Alt. Names/Synonyms: MEL; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); Oncogene c-mel; RAB8; RAB8A; RAB8A, member RAS oncogene family; ras-associated protein RAB8; Ras-related protein Rab-8A
Gene Symbols: RAB8A
Molecular weight: 23,668 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAB8A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 63 Y5-p ___MAKTyDYLFKLL
0 2 S17-p KLLLIGDsGVGKTCV
0 1 K58 ELDGKRIKLQIWDTA
0 8 T72-p AGQERFRtITTAyyR
0 5 Y77-p FRtITTAyyRGAMGI
0 4 Y78-p RtITTAyyRGAMGIM
0 1 S111-p RNIEEHAsADVEkMI
0 3 K116-ub HAsADVEkMILGNKC
0 1 K122 EkMILGNKCDVNDKR
0 1 K128 NKCDVNDKRQVsKER
0 3 S132-p VNDKRQVsKERGEkL
0 1 K133 NDKRQVsKERGEkLA
0 2 K138-ub VsKERGEkLALDYGI
0 1 K153 KFMETSAKANINVEN
0 50 T164-p NVENAFFtLARDIKA
0 19 S181-p DKKLEGNsPQGsNQG
0 19 S185-p EGNsPQGsNQGVkIt
0 1 K190-ub QGsNQGVkItPDQQK
0 5 T192-p sNQGVkItPDQQKRS
  mouse

 
Y5-p ___MAKTyDYLFKLL
S17-p KLLLIGDsGVGKTCV
K58 ELDGKRIKLQIWDTA
T72-p AGQERFRtITTAYYR
Y77 FRtITTAYYRGAMGI
Y78 RtITTAYYRGAMGIM
S111-p RNIEEHAsADVEkMI
K116-ub HAsADVEkMILGNkC
K122-ac EkMILGNkCDVNDkR
K128-ac NkCDVNDkRQVSkER
S132 VNDkRQVSkERGEkL
K133-ac NDkRQVSkERGEkLA
K138-ub VSkERGEkLALDYGI
K153-ub KFMETSAkANINVEN
T164-p NVENAFFtLARDIKA
S181-p DKKLEGNsPQGsSHG
S185-p EGNsPQGsSHGVKIT
K190 QGsSHGVKITVEQQK
T192 sSHGVKITVEQQKRT
  rat

 
Y5 ___MAKTYDYLFKLL
S17 KLLLIGDSGVGKTCV
K58-ub ELDGKRIkLQIWDTA
T72 AGQERFRTITTAYYR
Y77 FRTITTAYYRGAMGI
Y78 RTITTAYYRGAMGIM
S111 RNIEEHASADVEKMI
K116 HASADVEKMILGNKC
K122 EKMILGNKCDVNDKR
K128 NKCDVNDKRQVSKER
S132 VNDKRQVSKERGEKL
K133 NDKRQVSKERGEKLA
K138 VSKERGEKLALDYGI
K153 KFMETSAKANINVEN
T164 NVENAFFTLARDIKA
S181 DKKLEGNSPQGSSHG
S185 EGNSPQGSSHGVKIT
K190 QGSSHGVKITVEQQK
T192 SSHGVKITVEQQKRT
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