May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO/C1orf88. Interacts with BIRC6/bruce. Interacts with OCRL. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric, Rab; Motility/polarity/chemotaxis; G protein, monomeric
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein kinase binding; Rab GTPase binding
Biological Process: regulation of protein transport; regulation of long-term neuronal synaptic plasticity; protein transport; axonogenesis; Golgi vesicle fusion to target membrane; cellular response to insulin stimulus; GTP catabolic process; small GTPase mediated signal transduction; cilium biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; vesicle docking during exocytosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.