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Protein Page:
p73 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p73 a protein of the p53 family of proteins. p73, like p53, may have tumor suppressor activity, but its multiple isoforms possess different and sometimes opposing functions. Participates in the apoptotic response to DNA damage. Phosphorylated in a cell cycle-dependent manner and negatively regulated by CDKs. When overproduced, activates transcription from p53-responsive promoters and induces apoptosis. Nine transactivation competent (TA) or dominant negative (DN) isoforms, derived from alternative-splicing and alternative promoters, have been described. NH2-terminally truncated p73 isoforms (DNp73) may be oncogenic. DNp73 is elevated in a number of cancers and is associated with adverse clinical outcomes and resistance to chemotherapy. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9; forms complex with p53 and CABLES1. Isoform Beta interacts with WWOX; interacts with HECW2. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; chromatin; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; p53 binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; damaged DNA binding; chromatin binding; transcription factor binding; protein kinase binding; transcription factor activity
Biological Process: G1 DNA damage checkpoint; cerebrospinal fluid secretion; positive regulation of cell size; positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; post-embryonic development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; response to gamma radiation; positive regulation of oligodendrocyte differentiation; negative regulation of neuron apoptosis; inflammatory response; kidney development; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein tetramerization; response to X-ray; negative regulation of JNK activity; release of cytochrome c from mitochondria; mismatch repair; transcription, DNA-dependent; hippocampus development; digestive tract morphogenesis; response to organic nitrogen; negative regulation of neuron differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; neuron development; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus
Reference #:  O15350 (UniProtKB)
Alt. Names/Synonyms: p53-like transcription factor; p53-related protein; P73; TP73; Tumor protein p73
Gene Symbols: TP73
Molecular weight: 69,623 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p73

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: T86‑p, Y99‑p
cell cycle regulation: S388‑p
chromatin organization, altered: T86‑p
transcription, altered: Y99‑p, S388‑p
transcription, inhibited: T27‑p, T86‑p
activity, induced: Y99‑p, S388‑p
activity, inhibited: T27‑p, T86‑p
intracellular localization: T86‑p
molecular association, regulation: T27‑p
protein degradation: T86‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 T14 TSPDGGTTFEHLWSS
2 0 T27-p SSLEPDStyFDLPQS
1 0 Y28-p SLEPDStyFDLPQSS
1 0 S47-p EVVGGTDsSMDVFHL
0 1 - under review  
3 0 T86-p AASASPYtPEHAASV
5 0 Y99-p SVPTHSPyAQPSSTF
0 1 T167-p PIQIKVStPPPPGtA
0 1 T173-p StPPPPGtAIRAMPV
1 0 S235-p DPVTGRQsVVVPYEP
1 0 S289 GQVLGRRSFEGRICA
1 1 K321-ac ALNESSAkNGAASkR
1 1 K327-ac AkNGAASkRAFkQSP
1 0 K331-ac AASkRAFkQSPPAVP
0 1 K345-ub PALGAGVkKRRHGDE
1 0 S388-p VPQPLVDsYRQQQQL
1 0 S426-p GGMNKLPsVNQLVGQ
1 0 S471-p GEMSSSHsAQSMVSG
0 1 T568-p LRSSNAAtISIGGSG
2 0 K627-sm KARKQPIkEEFTEAE
4665 : Phospho-p73 (Tyr99) Antibody
  p73 iso2  
T14 TSPDGGTTFEHLWSS
T27 SSLEPDSTYFDLPQS
Y28 SLEPDSTYFDLPQSS
S47 EVVGGTDSSMDVFHL
- under review  
T86 AASASPYTPEHAASV
Y99-p SVPTHSPyAQPSSTF
T167 PIQIKVSTPPPPGTA
T173 STPPPPGTAIRAMPV
S235 DPVTGRQSVVVPYEP
S289-p GQVLGRRsFEGRICA
K321 ALNESSAKNGAASKR
K327 AKNGAASKRAFKQSP
K331 AASKRAFKQSPPAVP
K345 PALGAGVKKRRHGDE
S388 VPQPLVDSYRQQQQL
S426 GGMNKLPSVNQLVGQ
S471 GEMSSSHSAQSMVSG
- gap
- gap
4665 : Phospho-p73 (Tyr99) Antibody
  p73 iso8  
- gap
- gap
- gap
- gap
T13-p DPARHLAtAQFNLLS
T37 AASASPYTPEHAASV
Y50 SVPTHSPYAQPSSTF
T118 PIQIKVSTPPPPGTA
T124 STPPPPGTAIRAMPV
S186 DPVTGRQSVVVPYEP
S240 GQVLGRRSFEGRICA
K272 ALNESSAKNGAASKR
K278 AKNGAASKRAFKQSP
K282 AASKRAFKQSPPAVP
K296 PALGAGVKKRRHGDE
S339 VPQPLVDSYRQQQQL
S377 GGMNKLPSVNQLVGQ
S422 GEMSSSHSAQSMVSG
T519 LRSSNAATISIGGSG
K578 KARKQPIKEEFTEAE
  mouse

 
T11-p TSSSSSStFEHLWSS
T24 SSLEPDSTYFDLPQP
Y25 SLEPDSTYFDLPQPS
S44 EASGSEESNMDVFHL
M54 DVFHLQGMAQFNLLS
T78 AAPASPYTPEHAASA
Y91 SAPTHSPYAQPSSTF
T159 PIQIKVSTPPPPGTA
T165 STPPPPGTAIRAMPV
S227 DPVTGRQSVVVPYEP
S281 GQVLGRRSFEGRICA
K313 ALNESTTKNGAASKR
K319 TKNGAASKRAFKQSP
K323 AASKRAFKQSPPAIP
K337 PALGTNVKKRRHGDE
S380 VPQPLVDSYRQQQQQ
S420 GGVNKLPSVNQLVGQ
S465 GEMNGGHSSQTMVSG
T561 RSSSNAATISIGGSG
K622 KSRKQPIKEEFTETE
4665 : Phospho-p73 (Tyr99) Antibody
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