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HMOX2 (human)

Overview HMOX2 Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Belongs to the heme oxygenase family. Note: This description may include information from UniProtKB. Protein type: EC 1.14.99.3; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase Cellular Component: endoplasmic reticulum membrane; plasma membrane Molecular Function: protein binding; metal ion binding; heme oxygenase (decyclizing) activity Biological Process: heme catabolic process; cellular iron ion homeostasis; porphyrin metabolic process; response to hypoxia; heme oxidation; response to oxidative stress; transmembrane transport Reference #:  P30519 (UniProtKB) Alt. Names/Synonyms: heme oxygenase (decycling) 2; Heme oxygenase 2; HMOX2; HO-2; HO2 Gene Symbols: HMOX2 Molecular weight: 36,033 Da Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HMOX2 2Q32 - A/B=1-264 (human) 2QPP - A/B=1-264 (human) 2RGZ - A/B=1-264 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2Q32 2QPP 2RGZ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y140	KYVERIHYIGQNEPE
0	1		Y157-p	VAHAYTRyMGDLSGG
0	10		K199-u	VDNAQQFkQLyRARM
0	2		Y202-p	AQQFkQLyRARMNAL
0	1		K214	NALDLNMKTkERIVE
0	1		K216-a	LDLNMKTkERIVEEA
0	1		D251-ca	LARETLEdGFPVHDG
0	1		K259	GFPVHDGKGDMRKCP
0	1		T286-p	GSSCPFRtAMAVLRK

	mouse
Y139-p	KYVDRIHyVGQNEPE
Y156	VAHAYTRYMGDLSGG
K198-u	VDNAQQFkQFYRARM
Y201	AQQFkQFYRARMNAL
K213-u	NALDLNLkTKERIVE
K215	LDLNLkTKERIVEEA
D250	LARETLEDGLPVHDG
K258-u	GLPVHDGkGDIRKCP
T285	GSNCPFQTTVAVLRK

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