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p27Kip1 (human)

Overview p27Kip1 a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, regulatory subunit; Cell cycle regulation; Inhibitor protein Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus; endosome Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; caspase activator activity; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity Biological Process: negative regulation of kinase activity; nerve growth factor receptor signaling pathway; positive regulation of microtubule polymerization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of cell proliferation; sensory perception of sound; positive regulation of cell proliferation; negative regulation of mitotic cell cycle; cell cycle arrest; G1 phase of mitotic cell cycle; inner ear development; potassium ion transport; epidermal growth factor receptor signaling pathway; caspase activation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cell motility; induction of apoptosis; positive regulation of protein catabolic process; autophagic cell death; negative regulation of phosphorylation; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; S phase of mitotic cell cycle; negative regulation of transcription, DNA-dependent; cell cycle checkpoint; negative regulation of apoptosis; G1/S transition of mitotic cell cycle Reference #:  P46527 (UniProtKB) Alt. Names/Synonyms: CDKN1B; CDKN4; CDN1B; Cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; KIP1; MEN1B; MEN4; p27Kip1 Gene Symbols: CDKN1B Molecular weight: 22,073 Da Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below p27Kip1 1H27 - E=25-35 (human) 1JSU - C=23-106 (human) 2AST - D=181-190 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H27 1JSU 2AST  |  Phospho3D  |  DISEASE 600778 610755  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S10‑p apoptosis, inhibited: T157‑p cell adhesion, altered: S10‑p cell cycle regulation: S10‑p, Y74‑p, Y88‑p, Y89‑p, T157‑p, T187‑p, T198‑p cell growth, altered: T157‑p, T198‑p cell motility, induced: S10‑p cytoskeletal reorganization: S10‑p, T157‑p transcription, altered: S10‑p inhibition: Y88‑p, Y89‑p intracellular localization: S10‑p, Y88‑p, Y89‑p, T157‑p, T198‑p molecular association, regulation: S10‑p, Y74‑p, Y88‑p, Y89‑p, T157‑p, T187‑p, T198‑p phosphorylation: S10‑p, T157‑p protein conformation: S83‑p, T187‑p protein degradation: S10‑p, Y74‑p, Y88‑p, T157‑p, T187‑p, T198‑p protein stabilization: S10‑p, T187‑p, T198‑p ubiquitination: T187‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S7	_MSNVRVSNGsPSLE
38	12		S10-p	NVRVSNGsPSLErMD
0	2		S12	RVSNGsPSLErMDAR
0	1		R15-m1	NGsPSLErMDARQAE
7	0		Y74-p	HKPLEGKyEWQEVEk
0	1		K81-a	yEWQEVEkGsLPEFy
2	0		S83-p	WQEVEkGsLPEFyyR
9	0		Y88-p	kGsLPEFyyRPPRPP
6	0		Y89-p	GsLPEFyyRPPRPPK
0	8		S106-p	CKVPAQEsQDVSGSR
1	0		K134-u	DTHLVDPkTDPSDsQ
0	2		S140-p	PkTDPSDsQTGLAEQ
1	0		K153-u	EQCAGIRkrPAtDDS
0	1		R154-m2	QCAGIRkrPAtDDSS
18	1		T157-p	GIRkrPAtDDSSTQN
1	0		K165-u	DDSSTQNkRANRTEE
1	0		T170	QNkRANRTEENVSDG
4	3		S178-p	EENVSDGsPNAGsVE
0	1		S183-p	DGsPNAGsVEQtPKK
40	0		T187-p	NAGsVEQtPKKPGLR
19	6		T198-p	PGLRRRQt_______

	mouse
S7-p	_MSNVRVsNGsPsLE
S10-p	NVRVsNGsPsLERMD
S12-p	RVsNGsPsLERMDAR
R15	NGsPsLERMDARQAE
Y74	HKPLEGRYEWQEVER
R81	YEWQEVERGsLPEFy
S83-p	WQEVERGsLPEFyYR
Y88-p	RGsLPEFyYRPPRPP
Y89	GsLPEFyYRPPRPPK
S106-p	CKVLAQEsQDVSGSR
M134	DRHLVDQMPDSSDNP
N140	QMPDSSDNPAGLAEQ
K153	EQCPGMRKRPAaEDS
R154	QCPGMRKRPAaEDSS
A157-p	GMRKRPAaEDSSSQN
K165	EDSSSQNKRANRtEE
T170-p	QNKRANRtEENVSDG
S178-p	EENVSDGsPNAGTVE
T183	DGsPNAGTVEQtPKK
T187-p	NAGTVEQtPKKPGLR
T197-p	KPGLRRQt_______

	rat
S7	_MSNVRVSNGsPSLE
S10-p	NVRVSNGsPSLERMD
S12	RVSNGsPSLERMDAR
R15	NGsPSLERMDARQTE
Y74	HKPLEGRYEWQEVER
R81	YEWQEVERGSLPEFY
S83	WQEVERGSLPEFYYR
Y88	RGSLPEFYYRPPRPP
Y89	GSLPEFYYRPPRPPK
S106	CKVPAQESLDVSGSR
M134	DRHLVDQMPDSSDSP
S140	QMPDSSDSPAGLAEQ
K153	EQCPGMRKRPAAEDS
R154	QCPGMRKRPAAEDSS
A157	GMRKRPAAEDSSSQN
K165	EDSSSQNKRANRTEE
T170	QNKRANRTEENVSDG
S178-p	EENVSDGsPNAGTVE
T183	DGsPNAGTVEQTPKK
T187	NAGTVEQTPKKPGLR
T197	KPGLRRQT_______

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