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Protein Page:
TNFSF12 (human)

TNFSF12 Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q. Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Apoptosis; Membrane protein, integral; Cytokine
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: extracellular space; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding
Biological Process: positive regulation of angiogenesis; tumor necrosis factor-mediated signaling pathway; apoptosis; positive regulation of protein catabolic process; endothelial cell migration; immune response; positive regulation of endothelial cell proliferation; angiogenesis; signal transduction; cell differentiation
Reference #:  O43508 (UniProtKB)
Alt. Names/Synonyms: APO3 ligand; APO3/DR3 ligand; APO3L; DR3LG; MGC129581; MGC20669; TNF-related weak inducer of apoptosis; TNF12; TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; Tumor necrosis factor ligand superfamily member 12; Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form; TWEAK
Gene Symbols: TNFSF12
Molecular weight: 27,216 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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