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p21Cip1 (human)

Overview p21Cip1 a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Inhibitor protein Cellular Component: nucleoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus; cytosol Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; cyclin binding; cyclin-dependent protein kinase activating kinase activity; metal ion binding Biological Process: response to arsenic; response to toxin; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of B cell proliferation; G2/M transition of mitotic cell cycle; G1 phase of mitotic cell cycle; cell cycle arrest; response to UV; response to corticosterone stimulus; response to drug; organ regeneration; negative regulation of cyclin-dependent protein kinase activity; response to organic nitrogen; positive regulation of programmed cell death; response to hyperoxia; Ras protein signal transduction; cellular response to extracellular stimulus; negative regulation of phosphorylation; regulation of protein import into nucleus, translocation; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; negative regulation of cell growth; S phase of mitotic cell cycle; response to DNA damage stimulus; cell cycle checkpoint; negative regulation of apoptosis; G1/S transition of mitotic cell cycle Reference #:  P38936 (UniProtKB) Alt. Names/Synonyms: CAP20; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1; CDKN1A; CDN1A; CIP1; Cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA synthesis inhibitor; MDA-6; MDA6; melanoma differentiation associated protein 6; Melanoma differentiation-associated protein 6; p21; p21CIP1; p21Cip1/Waf1; PIC1; SDI1; WAF1; wild-type p53-activated fragment 1 Gene Symbols: CDKN1A Molecular weight: 18,119 Da Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Cell Cycle: G1/S Checkpoint  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below p21Cip1 1AXC - B/D/F=139-160 (human) 2ZVV - X/Y=139-160 (human) 2ZVW - O/J/N/P/K/M/I/L=139-160 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AXC 2ZVV 2ZVW  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: T57‑p, S130‑p, T145‑p cell growth, altered: S146‑p cell growth, inhibited: T145‑p intracellular localization: T57‑p, S130‑p, T145‑p, S146‑p, S153‑p molecular association, regulation: S130‑p, T145‑p, S146‑p, S153‑p protein degradation: K16‑u, T57‑p, K75‑u, S114‑p, S130‑p, K141‑u, K154‑u, K161‑u, K163‑u protein stabilization: T57‑p, S130‑p, T145‑p, S146‑p ubiquitination: K16‑u, T57‑p, K75‑u, S130‑p, K141‑u, K154‑u, K161‑u, K163‑u

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2	______MSEPAGDVR
2	0		K16-u	RQNPCGSkACRRLFG
4	0		T57-p	NFDFVTEtPLEGDFA
2	7		K75-u	VRGLGLPkLYLPTGP
1	0		Y77	GLGLPkLYLPTGPRR
1	2		P79	GLPkLYLPTGPRRGR
2	0		S98-p	GGRRPGTsPALLQGT
1	0		S114-p	EEDHVDLsLSCTLVP
1	0		S123-p	SCTLVPRsGEQAEGs
7	3		S130-p	sGEQAEGsPGGPGDS
1	0		K141-a	PGDSQGRkRRQtsMT
2	0		K141-u	PGDSQGRkRRQtsMT
14	0		T145-p	QGRkRRQtsMTDFYH
6	0		S146-p	GRkRRQtsMTDFYHs
2	0		S153-p	sMTDFYHskRRLIFS
1	0		K154-a	MTDFYHskRRLIFSk
2	0		K154-u	MTDFYHskRRLIFSk
1	0		K161-a	kRRLIFSkRkP____
2	0		K161-u	kRRLIFSkRkP____
1	0		K163-a	RLIFSkRkP______
2	0		K163-u	RLIFSkRkP______

	mouse
S2-p	______MsNPGDVRP
K15	RPVPHRSKVCRCLFG
T56	NFDFVTETPLEGNFV
K74	VRSLGLPKVyLsPGS
Y76-p	SLGLPKVyLsPGSRS
S78-p	GLPKVyLsPGSRSRD
S96	GDKRPSTSSALLQGP
S112	PEDHVALSLSCTLVS
-	gap
S125	VSERPEDSPGGPGTS
K136	PGTSQGRKRRQtsLT
K136	PGTSQGRKRRQtsLT
T140-p	QGRKRRQtsLTDFYH
S141-p	GRKRRQtsLTDFYHS
S148	sLTDFYHSKRRLVFC
K149	LTDFYHSKRRLVFCK
K149	LTDFYHSKRRLVFCK
K156	KRRLVFCKRKP____
K156	KRRLVFCKRKP____
K158	RLVFCKRKP______
K158	RLVFCKRKP______

	dog
-	gap
-	gap
T25	NFDFVTETPLEGDFA
K43	VRGLGLSKVSLPAGP
S45	GLGLSKVSLPAGPRG
P47	GLSKVSLPAGPRGGR
S66	GGKRPGTSPALLQGT
S82	QEDHLDLSLTCTLLP
S91-p	TCTLLPHsPERPEAS
S98	sPERPEASPGVPGTS
K109	PGTSQGRKRRQTSMT
K109	PGTSQGRKRRQTSMT
T113	QGRKRRQTSMTDFYH
S114	GRKRRQTSMTDFYHS
S121	SMTDFYHSKRRLIFS
K122	MTDFYHSKRRLIFSK
K122	MTDFYHSKRRLIFSK
K129	KRRLIFSKRKP____
K129	KRRLIFSKRKP____
K131	RLIFSKRKP______
K131	RLIFSKRKP______

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