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PARVA (human)

Overview PARVA Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis Cellular Component: protein complex; focal adhesion; lamellipodium; cytoplasm; plasma membrane; cytosol; nucleus; actin cytoskeleton Molecular Function: protein binding; actin binding Biological Process: heterotypic cell-cell adhesion; protein heterooligomerization; establishment and/or maintenance of cell polarity; sprouting angiogenesis; actin cytoskeleton organization and biogenesis Reference #:  Q9NVD7 (UniProtKB) Alt. Names/Synonyms: Actopaxin; Alpha-parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; Matrix-remodeling-associated protein 2; matrix-remodelling associated 2; MXRA2; PARVA; parvin, alpha Gene Symbols: PARVA Molecular weight: 42,244 Da Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PARVA 2K2R - A=244-372 (human) 2VZC - A/B=242-372 (human) 2VZD - A/B=242-372 (human) 2VZG - B=242-372 (human) 2VZI - B=242-372 (human) 3KMU - B=248-372 (human) 3KMW - B=248-372 (human) 3REP - B=248-372 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
signaling pathway regulation: S4‑p, S8‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T3	_____MATsPQKsPS
1	4		S4-p	____MATsPQKsPSV
1	10		S8-p	MATsPQKsPSVPKsP
0	38		S14-p	KsPSVPKsPtPKsPP
0	17		T16-p	PSVPKsPtPKsPPSR
0	43		S19-p	PKsPtPKsPPSRKKD
0	4		S28-p	PSRKKDDsFLGkLGG
0	3		K32-a	KDDsFLGkLGGtLAR
0	5		T36-p	FLGkLGGtLARRKKA
0	3		S62-p	NAINLPLsPIPFELD
0	1		T82-p	LEENEVRtMVDPNSR
0	1		S88	RtMVDPNSRSDPKLQ
0	10		Y124-p	KDLAEDLyDGQVLQK
0	1		K140	FEKLESEKLNVAEVT
0	1		T167-p	VLEKINEtLKLPPRs
0	1		K169	EKINEtLKLPPRsIK
0	5		S174-p	tLKLPPRsIKWNVDS
0	1		K260-u	LFDHAPDkLNVVKKT
0	1		K266	DkLNVVKKTLITFVN
0	1		T284-p	NKLNLEVtELETQFA

	PARVA iso3
T43-p	SLRRAMAtsPQKSPS
S44-p	LRRAMAtsPQKSPSV
S48	MAtsPQKSPSVPKSP
S54	KSPSVPKSPTPKSPP
T56	PSVPKSPTPKSPPSR
S59	PKSPTPKSPPSRKKD
S68	PSRKKDDSFLGKLGG
K72	KDDSFLGKLGGTLAR
T76	FLGKLGGTLARRKKA
S102	NAINLPLSPIPFELD
T122	LEENEVRTMVDPNSR
S128	RTMVDPNSRSDPKLQ
Y164	KDLAEDLYDGQVLQK
K180	FEKLESEKLNVAEVT
T207	VLEKINETLKLPPRS
K209	EKINETLKLPPRSIK
S214	TLKLPPRSIKWNVDS
K300	LFDHAPDKLNVVKKT
K306	DKLNVVKKTLITFVN
T324	NKLNLEVTELETQFA

	mouse
T3	_____MATSPQKsPL
S4	____MATSPQKsPLV
S8-p	MATSPQKsPLVPKsP
S14-p	KsPLVPKsPtPKsPP
T16-p	PLVPKsPtPKsPPSR
S19-p	PKsPtPKsPPSRKKD
S28-p	PSRKKDDsFLGKLGG
K32	KDDsFLGKLGGtLAR
T36-p	FLGKLGGtLARRKKA
S62	NAINLPLSPISFELD
T82	LEENEVRTMVDPNsR
S88-p	RTMVDPNsRNDPKLQ
Y124	KDLAEDLYDGQVLQK
K140-u	FEKLESEkLNVAEVT
T167	VLEKINETLkLPPRS
K169-u	EKINETLkLPPRSIK
S174	TLkLPPRSIKWNVDS
K260	LFDHAPDKLNVVKkT
K266-u	DKLNVVKkTLITFVN
T284	NKLNLEVTELETQFA

	rat
T3	_____MATSPQKSPS
S4	____MATSPQKSPSV
S8	MATSPQKSPSVPKSP
S14	KSPSVPKSPtPKsPP
T16-p	PSVPKSPtPKsPPSR
S19-p	PKSPtPKsPPSRKKD
S28	PSRKKDDSFLGKLGG
K32	KDDSFLGKLGGTLAR
T36	FLGKLGGTLARRKKA
S62	NAINLPLSPISFELD
T82	LEENEVRTMVDPNSR
S88	RTMVDPNSRNDPKLQ
Y124	KDLAEDLYDGQVLQK
K140	FEKLESEKLNVAEVT
A167	VLEKINEALKLPPRS
K169	EKINEALKLPPRSIK
S174	ALKLPPRSIKWNVDS
K260	LFDHAPDKLNVVKKT
K266	DKLNVVKKTLITFVN
T284	NKLNLEVTELETQFA

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