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Protein Page:
PARVA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PARVA Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: focal adhesion; cytoplasm; plasma membrane; cytosol; Z disc; actin cytoskeleton
Molecular Function: protein binding; actin binding
Biological Process: regulation of cell shape; heterotypic cell-cell adhesion; actin cytoskeleton reorganization; establishment and/or maintenance of cell polarity; sprouting angiogenesis
Reference #:  Q9NVD7 (UniProtKB)
Alt. Names/Synonyms: Actopaxin; Alpha-parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; Matrix-remodeling-associated protein 2; matrix-remodelling associated 2; MXRA2; PARVA; parvin, alpha
Gene Symbols: PARVA
Molecular weight: 42,244 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PARVA

Protein Structure Not Found.


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Sites Implicated In
signaling pathway regulation: S4‑p, S8‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T3-p _____MAtsPQKsPs
1 5 S4-p ____MAtsPQKsPsV
1 14 S8-p MAtsPQKsPsVPKsP
0 2 S10-p tsPQKsPsVPKsPtP
0 46 S14-p KsPsVPKsPtPKsPP
0 21 T16-p PsVPKsPtPKsPPsR
0 50 S19-p PKsPtPKsPPsRKKD
0 1 S22-p PtPKsPPsRKKDDsF
0 6 S28-p PsRKKDDsFLGkLGG
0 4 K32-ac KDDsFLGkLGGtLAR
0 7 T36-p FLGkLGGtLARRKKA
0 3 S62-p NAINLPLsPIPFELD
0 2 T82-p LEENEVRtMVDPNSR
0 1 S88 RtMVDPNSRSDPKLQ
0 10 Y124-p KDLAEDLyDGQVLQK
0 1 K140 FEKLESEKLNVAEVT
0 1 T167-p VLEKINEtLKLPPRs
0 1 K169 EKINEtLKLPPRsIK
0 6 S174-p tLKLPPRsIKWNVDS
0 1 K260-ub LFDHAPDkLNVVKKT
0 1 K266 DkLNVVKKTLITFVN
0 1 T284-p NKLNLEVtELETQFA
  PARVA iso4  
T43-p SLRRAMAtsPQKSPS
S44-p LRRAMAtsPQKSPSV
S48 MAtsPQKSPSVPKSP
S50 tsPQKSPSVPKSPTP
S54 KSPSVPKSPTPKSPP
T56 PSVPKSPTPKSPPSR
S59 PKSPTPKSPPSRKKD
S62 PTPKSPPSRKKDDSF
S68 PSRKKDDSFLGKLGG
K72 KDDSFLGKLGGTLAR
T76 FLGKLGGTLARRKKA
S102 NAINLPLSPIPFELD
T122 LEENEVRTMVDPNSR
S128 RTMVDPNSRSDPKLQ
Y164 KDLAEDLYDGQVLQK
K180 FEKLESEKLNVAEVT
T207 VLEKINETLKLPPRS
K209 EKINETLKLPPRSIK
S214 TLKLPPRSIKWNVDS
K300 LFDHAPDKLNVVKKT
K306 DKLNVVKKTLITFVN
T324 NKLNLEVTELETQFA
  mouse

 
T3 _____MATSPQKsPL
S4 ____MATSPQKsPLV
S8-p MATSPQKsPLVPKsP
L10 TSPQKsPLVPKsPtP
S14-p KsPLVPKsPtPKsPP
T16-p PLVPKsPtPKsPPsR
S19-p PKsPtPKsPPsRKKD
S22-p PtPKsPPsRKKDDsF
S28-p PsRKKDDsFLGkLGG
K32-ac KDDsFLGkLGGtLAR
T36-p FLGkLGGtLARRKKA
S62 NAINLPLSPISFELD
T82 LEENEVRTMVDPNsR
S88-p RTMVDPNsRNDPKLQ
Y124 KDLAEDLYDGQVLQK
K140-ub FEKLESEkLNVAEVT
T167 VLEKINETLkLPPRS
K169-ub EKINETLkLPPRSIK
S174 TLkLPPRSIKWNVDS
K260 LFDHAPDKLNVVKkT
K266-ub DKLNVVKkTLITFVN
T284 NKLNLEVTELETQFA
  rat

 
T3 _____MATSPQKsPS
S4 ____MATSPQKsPSV
S8-p MATSPQKsPSVPKsP
S10 TSPQKsPSVPKsPtP
S14-p KsPSVPKsPtPKsPP
T16-p PSVPKsPtPKsPPSR
S19-p PKsPtPKsPPSRKKD
S22 PtPKsPPSRKKDDSF
S28 PSRKKDDSFLGKLGG
K32 KDDSFLGKLGGTLAR
T36 FLGKLGGTLARRKKA
S62 NAINLPLSPISFELD
T82 LEENEVRTMVDPNSR
S88 RTMVDPNSRNDPKLQ
Y124 KDLAEDLYDGQVLQK
K140 FEKLESEKLNVAEVT
A167 VLEKINEALKLPPRS
K169 EKINEALKLPPRSIK
S174 ALKLPPRSIKWNVDS
K260 LFDHAPDKLNVVKKT
K266 DKLNVVKKTLITFVN
T284 NKLNLEVTELETQFA
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