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Protein Page:
PDGFA (human)

PDGFA Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cell cycle regulation; Cytokine; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p22
Cellular Component: Golgi membrane; extracellular space; cell surface; microvillus; endoplasmic reticulum lumen; extracellular region
Molecular Function: collagen binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding
Biological Process: skin development; axon guidance; extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; activation of MAPKK activity; wound healing; negative chemotaxis; platelet-derived growth factor receptor signaling pathway; cell projection biogenesis; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; platelet degranulation; regulation of smooth muscle cell migration; cell-cell signaling; hair follicle development; positive regulation of MAPKKK cascade; small GTPase mediated signal transduction; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to wounding; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of phosphatidylinositol biosynthetic process; MAPKKK cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; cell activation; organ morphogenesis; gut development; regulation of actin cytoskeleton organization and biogenesis; positive regulation of cell division; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; blood coagulation; alveolus development; positive regulation of DNA replication; positive regulation of cell migration
Reference #:  P04085 (UniProtKB)
Alt. Names/Synonyms: PDGF A-chain; PDGF subunit A; PDGF-1; PDGF-A; PDGF1; PDGFA; Platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A
Gene Symbols: PDGFA
Molecular weight: 24,043 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 S108-p VIYEIPRsQVDPtsA
0 1 T113-p PRsQVDPtsANFLIW
0 1 S114-p RsQVDPtsANFLIWP

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