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eIF4E2 (human)

Overview eIF4E2 Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners. EIF4E2 interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 but not with eIF4G. Belongs to the eukaryotic initiation factor 4E family. Note: This description may include information from UniProtKB. Protein type: Translation initiation; Translation Cellular Component: mRNA cap complex; cytosol Molecular Function: protein binding; translation factor activity, nucleic acid binding; ubiquitin protein ligase binding; translation initiation factor activity; RNA cap binding Biological Process: regulation of translation; cytokine and chemokine mediated signaling pathway Reference #:  O60573 (UniProtKB) Alt. Names/Synonyms: 4E-LP; 4EHP; eIF-4E type 2; eIF4E type 2; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; EIF4E2; EIF4EL3; eukaryotic translation initiation factor 4E family member 2; Eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E member 2; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; IF4e; IF4E2; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 3 Gene Symbols: EIF4E2 Molecular weight: 28,362 Da Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF4E2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	3		S13-p	DALKDDDsGDHDQNE
0	1		K134-a	DANKNGGkWIIRLRK
0	3		K239-u	LLFQNLWkPrLNVP_
0	1		R241-m1	FQNLWkPrLNVP___

	mouse ► Hide Isoforms
-	gap
S13-p	DALKDDDsGDHDQNE
K134	DANKNGGKWIIRLRK
K239-u	LLFQNLWkPRLNVP_
R241	FQNLWkPRLNVP___

	eIF4E2 iso3
S2-p	______MsLKDDDSG
S8	MsLKDDDSGDHDQNE
K129	DANKNGGKWIIRLRK
K234	LLFQNLWKPRLNVP_
R236	FQNLWKPRLNVP___

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