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Protein Page:
eIF4E2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF4E2 Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners. EIF4E2 interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 but not with eIF4G. Belongs to the eukaryotic initiation factor 4E family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: mRNA cap complex; cytosol
Molecular Function: protein binding; translation factor activity, nucleic acid binding; ubiquitin protein ligase binding; translation initiation factor activity; RNA cap binding
Biological Process: in utero embryonic development; cytokine and chemokine mediated signaling pathway; negative regulation of translation; translational initiation
Reference #:  O60573 (UniProtKB)
Alt. Names/Synonyms: 4E-LP; 4EHP; eIF-4E type 2; eIF4E type 2; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; EIF4E2; EIF4EL3; eukaryotic translation initiation factor 4E family member 2; Eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E member 2; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; IF4e; IF4E2; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 3
Gene Symbols: EIF4E2
Molecular weight: 28,362 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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eIF4E2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 9 S13-p DALKDDDsGDHDQNE
0 1 T68-p TFWYSRRtPGRPTSs
0 1 S75-p tPGRPTSsQSYEQNI
0 1 K134-ac DANKNGGkWIIRLRK
0 3 K239-ub LLFQNLWkPrLNVP_
0 2 R241-m1 FQNLWkPrLNVP___
  mouse

► Hide Isoforms
 
- gap
S13-p DALKDDDsGDHDQNE
T68 TFWYSRRTPGRPTSS
S75 TPGRPTSSQSYEQNI
K134 DANKNGGKWIIRLRK
K239-ub LLFQNLWkPRLNVP_
R241 FQNLWkPRLNVP___
  eIF4E2 iso3  
S2-p ______MsLKDDDSG
S8 MsLKDDDSGDHDQNE
T63 TFWYSRRTPGRPTSS
S70 TPGRPTSSQSYEQNI
K129 DANKNGGKWIIRLRK
K234 LLFQNLWKPRLNVP_
R236 FQNLWKPRLNVP___
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