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REN (human)

Overview REN Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.23.15 Cellular Component: extracellular space; membrane; cytoplasmic part Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding Biological Process: response to drug; response to cAMP; hormone-mediated signaling; male gonad development; drinking behavior; cell maturation; renin-angiotensin regulation of aldosterone production; proteolysis; angiotensin maturation; regulation of blood pressure; regulation of MAPKKK cascade; response to stress; mesonephros development; kidney development Reference #:  P00797 (UniProtKB) Alt. Names/Synonyms: angiotensin-forming enzyme; Angiotensinogenase; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor, renal Gene Symbols: REN Molecular weight: 45,057 Da Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below REN 1BBS - A/B=67-406 (human) 1BIL - A/B=70-406 (human) 1BIM - A/B=70-406 (human) 1HRN - A/B=70-406 (human) 1RNE - A=67-406 (human) 2BKS - A/B=67-406 (human) 2BKT - A/B=67-406 (human) 2FS4 - A/B=74-406 (human) 2G1N - A/B=74-406 (human) 2G1O - A/B=74-406 (human) 2G1R - A/B=74-406 (human) 2G1S - A/B=74-406 (human) 2G1Y - A/B=74-406 (human) 2G20 - A/B=74-406 (human) 2G21 - A/B=74-406 (human) 2G22 - A/B=74-406 (human) 2G24 - A/B=74-406 (human) 2G26 - A/B=74-406 (human) 2G27 - A/B=74-406 (human) 2I4Q - A/B=71-406 (human) 2IKO - A/B=67-406 (human) 2IKU - A/B=67-406 (human) 2IL2 - A/B=67-406 (human) 2REN - A=67-406 (human) 2V0Z - C/O=67-406 (human) 2V10 - C/O=67-406 (human) 2V11 - C/O=67-406 (human) 2V12 - C/O=67-406 (human) 2V13 - A=67-406 (human) 2V16 - O/C=67-406 (human) 2X0B - A/C/G/E=24-406 (human) 3D91 - A/B=67-406 (human) 3G6Z - A/B=67-406 (human) 3G70 - A/B=67-406 (human) 3G72 - A/B=67-406 (human) 3GW5 - A/B=70-406 (human) 3K1W - A/B=67-406 (human) 3KM4 - A/B=70-406 (human) 3O9L - A/C=67-232 D/B=237-406 (human) 3OAD - A/C=67-232 D/B=237-406 (human) 3OAG - A/C=67-232 D/B=237-406 (human) 3OOT - A/B=67-406 (human) 3OQF - A/B=67-406 (human) 3OQK - A/B=67-406 (human) 3OWN - A/B=67-406 (human) 3Q3T - A/B=67-406 (human) 3Q4B - A/B=67-406 (human) 3Q5H - A/B=67-406 (human) 3SFC - A/B=67-406 (human) 3VCM - A/B=67-406 Q/P=24-66 (human) 3VSW - A/B=67-406 (human) 3VSX - A/B=67-406 (human) 3VUC - A/B=67-406 (human) 3VYD - A/B=67-406 (human) 3VYE - A/B=67-406 (human) 3VYF - A/B=67-406 (human) 4AMT - A=24-406 (human) 4GJ5 - A/B=67-406 (human) 4GJ6 - A/B=67-406 (human) 4GJ7 - A/B=67-406 (human) 4GJ8 - A/B=67-406 (human) 4GJ9 - A/B=67-406 (human) 4GJA - A/B=67-406 (human) 4GJB - A/B=67-406 (human) 4GJC - A/B=67-406 (human) 4GJD - A/B=67-406 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD  |  ENZYME  |  Phospho3D  |  DISEASE 179820 267430  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S41-p	IFLKRMPsIREsLKE
0	1		S45-p	RMPsIREsLKERGVD
0	1		Y87-p	NYMDTQYyGEIGIGT
0	1		T330-p	VKCNEGPtLPDISFH
0	1		S347-p	GKEYTLTsADYVFQE
0	1		S355-p	ADYVFQEsYSSKKLC

	mouse
S39	IPLKKMPSVREILEE
I43	KMPSVREILEERGVD
Y85	NYLNTQYYGEIGIGT
T326	VNCSQVPTLPDISFD
S343	GRAYTLSSTDYVLQY
P351	TDYVLQYPNRRDKLC

	rat
S39	ILLKKMPSVREILEE
I43	KMPSVREILEERGVD
Y85	NYLDTQYYGEIGIGT
T326	VNCSQVPTLPDISFY
N343	GRTYTLSNMDYVQKN
P351	MDYVQKNPFRNDDLC

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