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Protein Page:
REN (human)

Overview
REN Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.23.15
Cellular Component: extracellular space; extracellular region; plasma membrane; intracellular
Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding
Biological Process: response to cAMP; hormone-mediated signaling; drinking behavior; cell maturation; renin-angiotensin regulation of aldosterone production; male gonad development; response to lipopolysaccharide; proteolysis; angiotensin maturation; cellular protein metabolic process; regulation of MAPKKK cascade; beta-amyloid metabolic process; regulation of blood pressure; mesonephros development; kidney development
Reference #:  P00797 (UniProtKB)
Alt. Names/Synonyms: angiotensin-forming enzyme; Angiotensinogenase; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor, renal
Gene Symbols: REN
Molecular weight: 45,057 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

REN

Protein Structure Not Found.


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