Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Protease; Secreted; EC 184.108.40.206
Cellular Component: extracellular space; membrane; cytoplasmic part
Biological Process: response to drug; response to cAMP; hormone-mediated signaling; male gonad development; drinking behavior; cell maturation; renin-angiotensin regulation of aldosterone production; proteolysis; angiotensin maturation; regulation of blood pressure; regulation of MAPKKK cascade; response to stress; mesonephros development; kidney development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.