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Protein Page:
N-Myc (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
N-Myc a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleus; chromatin
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; positive regulation of mesenchymal cell proliferation; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; cartilage condensation; lung development; embryonic skeletal morphogenesis
Reference #:  P04198 (UniProtKB)
Alt. Names/Synonyms: BHLHE37; Class E basic helix-loop-helix protein 37; MODED; MYCN; N-myc; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; ODED; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Gene Symbols: MYCN
Molecular weight: 49,561 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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N-Myc

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T58‑p, S62‑p
ubiquitination: T58‑p, S62‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 22 T58-p KKFELLPtPPLsPsR
1 20 S62-p LLPtPPLsPsRGFAE
0 6 S64-p PtPPLsPsRGFAEHS
0 1 K133 LERAVSEKLQHGRGP
0 2 S156-p SPGAGAAsPAGRGHG
1 0 S261-p TSGEDTLsDsDDEDD
1 0 S263-p GEDTLsDsDDEDDEE
  mouse

 
T58-p KKFELLPtPPLsPsR
S62-p LLPtPPLsPsRAFPE
S64-p PtPPLsPsRAFPEHS
K134-ub LERAVNEkLQHGHGP
S157-p APGVGASsPGGRALG
S259 TSGEDTLSDSDDEDD
S261 GEDTLSDSDDEDDEE
  rat

 
T58 KKFELLPTPPLSPSR
S62 LLPTPPLSPSRAFPE
S64 PTPPLSPSRAFPEHS
K134 LERAVNEKLQHGHGP
S157 APGVGASSSGGRALG
S259 TSGEDTLSDSDDEDD
S261 GEDTLSDSDDEDDEE
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