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Protein Page:
N-Myc (human)

Overview
N-Myc a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: chromatin; nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; negative regulation of astrocyte differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; cartilage condensation; lung development; embryonic skeletal morphogenesis
Reference #:  P04198 (UniProtKB)
Alt. Names/Synonyms: BHLHE37; Class E basic helix-loop-helix protein 37; MODED; MYCN; N-myc; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; ODED; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Gene Symbols: MYCN
Molecular weight: 49,561 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

N-Myc

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T58‑p, S62‑p
ubiquitination: T58‑p, S62‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 21 T58-p KKFELLPtPPLsPsR
1 19 S62-p LLPtPPLsPsRGFAE
0 5 S64-p PtPPLsPsRGFAEHS
0 1 S156-p SPGAGAAsPAGRGHG
1 0 S261-p TSGEDTLsDsDDEDD
1 0 S263-p GEDTLsDsDDEDDEE
  mouse

 
T58-p KKFELLPtPPLsPsR
S62-p LLPtPPLsPsRAFPE
S64-p PtPPLsPsRAFPEHS
S157-p APGVGASsPGGRALG
S259 TSGEDTLSDSDDEDD
S261 GEDTLSDSDDEDDEE
  rat

 
T58 KKFELLPTPPLSPSR
S62 LLPTPPLSPSRAFPE
S64 PTPPLSPSRAFPEHS
S157 APGVGASSSGGRALG
S259 TSGEDTLSDSDDEDD
S261 GEDTLSDSDDEDDEE
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