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N-Myc (human)

Overview N-Myc a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: chromatin; nucleus Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; negative regulation of astrocyte differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; cartilage condensation; lung development; embryonic skeletal morphogenesis Reference #:  P04198 (UniProtKB) Alt. Names/Synonyms: BHLHE37; Class E basic helix-loop-helix protein 37; MODED; MYCN; N-myc; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; ODED; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) Gene Symbols: MYCN Molecular weight: 49,561 Da Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below N-Myc

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 164280 164840 602585  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: T58‑p, S62‑p ubiquitination: T58‑p, S62‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	20		T58-p	KKFELLPtPPLsPsR
1	18		S62-p	LLPtPPLsPsRGFAE
0	4		S64-p	PtPPLsPsRGFAEHS
0	1		K133	LERAVSEKLQHGRGP
0	1		S156-p	SPGAGAAsPAGRGHG
1	0		S261-p	TSGEDTLsDsDDEDD
1	0		S263-p	GEDTLsDsDDEDDEE

	mouse
T58-p	KKFELLPtPPLsPsR
S62-p	LLPtPPLsPsRAFPE
S64-p	PtPPLsPsRAFPEHS
K134-u	LERAVNEkLQHGHGP
S157	APGVGASSPGGRALG
S259	TSGEDTLSDSDDEDD
S261	GEDTLSDSDDEDDEE

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