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NKX2-2 (human)

Overview NKX2-2 Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Cell development/differentiation Cellular Component: nucleoplasm Molecular Function: sequence-specific DNA binding; transcription coactivator activity; chromatin binding; transcription factor binding; transcription factor activity Biological Process: smoothened signaling pathway; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; spinal cord motor neuron differentiation; endocrine pancreas development; negative regulation of neuron differentiation; astrocyte differentiation; gut development; neuron fate specification; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; brain development; positive regulation of oligodendrocyte differentiation; positive regulation of neuron differentiation; oligodendrocyte development Reference #:  O95096 (UniProtKB) Alt. Names/Synonyms: Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; NK-2 homolog B; NK2 homeobox 2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; NKX2-2; NKX2.2; NKX22; NKX2B Gene Symbols: NKX2-2 Molecular weight: 30,133 Da Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NKX2-2

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S58-p	GALDAVQsLPLKNPF
0	1		T6-p	__MSLTNtKtGFsVK
0	1		T8-p	MSLTNtKtGFsVKDI
0	1		S11-p	TNtKtGFsVKDILDL
0	2		N63	VQsLPLKNPFYDSSD

	mouse
S58	GALDAVQSLPLKsPF
T6	__MSLTNTKTGFSVK
T8	MSLTNTKTGFSVKDI
S11	TNTKTGFSVKDILDL
S63-p	VQSLPLKsPFYDSSD

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