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Rab11FIP1 (human)

Overview Rab11FIP1 A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo. Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Vesicle protein Cellular Component: phagocytic vesicle membrane; recycling endosome; intracellular membrane-bound organelle; cytoplasm Biological Process: protein transport Reference #:  Q6WKZ4 (UniProtKB) Alt. Names/Synonyms: DKFZp686E2214; FLJ22524; FLJ22622; MGC78448; NOEL1A; Rab effector protein; Rab-coupling protein; Rab-interacting recycling protein; RAB11 coupling protein; RAB11 family interacting protein 1 (class I); Rab11 family-interacting protein 1; Rab11-FIP1; RAB11FIP1; RCP; RFIP1 Gene Symbols: RAB11FIP1 Molecular weight: 137,195 Da Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rab11FIP1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K129-a	KTQWYKLkSkPGKKD
0	1		K131-a	QWYKLkSkPGKKDKE
0	13		S156-p	MRNNMTAsMFDLSMK
0	1		S184	IKGKNKDSGSDTASA
0	1		S186	GKNKDSGSDTASAII
0	1		S195	TASAIIPSTTPsVDs
0	2		T197	SAIIPSTTPsVDsDD
0	4		S199-p	IIPSTTPsVDsDDEs
0	8		S202-p	STTPsVDsDDEsVVK
0	2		S206-p	sVDsDDEsVVKDKKK
0	3		S234-p	QKTPLSQsMsVLPTS
0	1		S236-p	TPLSQsMsVLPTSKP
0	1		S266-p	EDDNEDEsSsASDVM
0	1		S268-p	DNEDEsSsASDVMSH
0	19		T278-p	DVMSHKRtAstDLKQ
0	93		S280-p	MSHKRtAstDLKQLN
0	17		T281-p	SHKRtAstDLKQLNQ
0	1		T292-p	QLNQVNFtLPKKEGL
0	3		S300-p	LPKKEGLsFLGGLRS
0	1		S315-p	KNDVLSRsNVCINGN
0	11		Y325-p	CINGNHVyLEQPEAK
0	2		S338-p	AKGEIKDssPsssPs
0	13		S339-p	KGEIKDssPsssPsP
0	11		S341-p	EIKDssPsssPsPKG
0	1		S342-p	IKDssPsssPsPKGF
0	16		S343-p	KDssPsssPsPKGFR
0	19		S345-p	ssPsssPsPKGFRKK
0	1		H353	PKGFRKKHLFsstEN
0	12		S356-p	FRKKHLFsstENLAA
0	33		S357-p	RKKHLFsstENLAAG
0	15		T358-p	KKHLFsstENLAAGs
0	6		S365-p	tENLAAGsWKEPAEG
0	3		S382-p	LSSDRQLsEsStkDs
0	1		S384-p	SDRQLsEsStkDsLK
0	2		T386-p	RQLsEsStkDsLKSM
0	1		K387-a	QLsEsStkDsLKSMt
0	3		S389-p	sEsStkDsLKSMtLP
0	1		T394-p	kDsLKSMtLPsyRPA
0	2		S397-p	LKSMtLPsyRPAPLV
0	2		Y398-p	KSMtLPsyRPAPLVS
0	26		S435-p	KPESRRSsLLsLMtG
0	2		S438-p	SRRSsLLsLMtGkKD
0	2		T441-p	SsLLsLMtGkKDVAK
0	2		K443-a	LLsLMtGkKDVAKGS
0	2		S477-p	VKPGEDAsGPAEDLV
0	1		S487-p	AEDLVRRsEKDtAAV
0	1		T491-p	VRRsEKDtAAVVsRQ
0	23		S496-p	KDtAAVVsRQGssLN
0	94		S500-p	AVVsRQGssLNLFED
0	53		S501-p	VVsRQGssLNLFEDV
0	3		S519-p	EPEAEPEsKsEPRPP
0	3		S521-p	EAEPEsKsEPRPPIS
0	8		S545-p	VKPRLEVsPEAQPTA
0	1		S556	QPTARLPSPTDSPSS
0	1		S640	KAELQTESLTPVPNS
0	1		T642	ELQTESLTPVPNSGS
0	1		S647	SLTPVPNSGSSVLGS
0	3		S660-p	GSLFKQPsFPANKGT
0	1		T684-p	ETGTEKNtssLELEE
0	1		S685-p	TGTEKNtssLELEEs
0	1		S686-p	GTEKNtssLELEEsL
0	1		S692-p	ssLELEEsLPEQPET
0	1		S754-p	GGDRDLEsQAGsLVE
0	1		S758-p	DLEsQAGsLVESKAR
0	1		K800-a	EMGLNLRkDQkKTKK
0	1		K803-a	LNLRkDQkKTKKRVS
0	4		P853	GNASDGEPPESPHAE
0	1		S862	ESPHAEDSERESVTT
0	1		S880-p	ATCGAPAsPADHLLL
0	4		S967-p	PSIPEVAsDDERIDQ
0	1		S1135-p	KKATAEGsAGRVENF
0	1		T1187-p	KPMNAMAtKVANCSL
0	3		K1211	LNNEVMMKkYsPsDP
0	1		K1212-u	NNEVMMKkYsPsDPA
0	2		S1214-p	EVMMKkYsPsDPAFA
0	1		S1216-p	MMKkYsPsDPAFAYA
0	1		T1226-p	AFAYAQLtHDELIQL
0	1		K1236-u	ELIQLVLkQKETISK
0	33		T1274-p	PNILRIPtQVGKKAG

	Rab11FIP1 iso7
K129	KTQWYKLKSKPGKKD
K131	QWYKLKSKPGKKDKE
S156	MRNNMTASMFDLSMK
S184	IKGKNKDSGSDTASA
S186	GKNKDSGSDTASAII
S195	TASAIIPSTTPSVDS
T197	SAIIPSTTPSVDSDD
S199	IIPSTTPSVDSDDES
S202	STTPSVDSDDESVVK
S206	SVDSDDESVVKDKKK
S234	QKTPLSQSMSVLPTS
S236	TPLSQSMSVLPTSKP
S266	EDDNEDESSSASDVM
S268	DNEDESSSASDVMSH
T278	DVMSHKRTASTDLKQ
S280	MSHKRTASTDLKQLN
T281	SHKRTASTDLKQLNQ
T292	QLNQVNFTLPKKEGL
S300	LPKKEGLSFLGGLRS
S315	KNDVLSRSNVCINGN
Y325	CINGNHVYLEQPQPT
S338	PTGEIKDSSPSSSPS
S339	TGEIKDSSPSSSPSP
S341	EIKDSSPSSSPSPKG
S342	IKDSSPSSSPSPKGF
S343	KDSSPSSSPSPKGFR
S345	SSPSSSPSPKGFRKK
T353-p	PKGFRKKtLFSStEN
S356	FRKKtLFSStENLAA
S357	RKKtLFSStENLAAG
T358-p	KKtLFSStENLAAGS
S365	tENLAAGSWKEPAEG
S382	LSTDRDVSESSTKDS
S384	TDRDVSESSTKDSLK
T386	RDVSESSTKDSLKSM
K387	DVSESSTKDSLKSMT
S389	SESSTKDSLKSMTLP
T394	KDSLKSMTLPTYRPA
T397	LKSMTLPTYRPAPLI
Y398	KSMTLPTYRPAPLIS
S435	KPESRRSSLLSLMTG
S438	SRRSSLLSLMTGKKD
T441	SSLLSLMTGKKDVAK
K443	LLSLMTGKKDVAKGS
S477	VKPGEDASGPAEDLV
S487	AEDLVRRSEKDTAAV
T491	VRRSEKDTAAVVSRQ
S496	KDTAAVVSRQGSSLN
S500	AVVSRQGSSLNLFED
S501	VVSRQGSSLNLFEDV
S519	EPEAEPESKSEPRPP
S521	EAEPESKSEPRPPIS
-	gap
-	gap
-	under review
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T553	KPMNATATKVANCSL
K577	LNNEVMMKKYSPSDP
K578	NNEVMMKKYSPSDPA
S580	EVMMKKYSPSDPAFA
S582	MMKKYSPSDPAFAYA
T592	AFAYAQLTHDELIQL
K602	ELIQLVLKQKETISK
T640	PNILRIPTQVGKKAG

	mouse
K131	KKQWYTLKSKPGKKD
K133	QWYTLKSKPGKKDKE
S158-p	MRNNMTAsMFDLSMK
S186-p	IKGKNKDsAsDTASA
S188-p	GKNKDsAsDTASAIV
S197-p	TASAIVPsVtPsVDs
T199-p	SAIVPsVtPsVDsDD
S201-p	IVPsVtPsVDsDDEs
S204-p	sVtPsVDsDDEsFSK
S208-p	sVDsDDEsFSKDKKK
S236-p	QKTPLSQsMsVLPTS
S238-p	TPLSQsMsVLPTSKS
S268	DDAHEDESSSASDVM
S270	AHEDESSSASDVMSH
T280-p	DVMSHKRtSstDQQP
S282-p	MSHKRtSstDQQPNQ
T283-p	SHKRtSstDQQPNQS
S293	QPNQSNFSLPKKEGL
S301	LPKKEGLSFLGGLRS
S316-p	KNDSLSRsTVCINGN
Y326	CINGNHVYMEQPEAR
S339-p	ARSEIREssPsNsPs
S340-p	RSEIREssPsNsPsP
S342-p	EIREssPsNsPsPQG
N343	IREssPsNsPsPQGF
S344-p	REssPsNsPsPQGFR
S346-p	ssPsNsPsPQGFRRK
H354	PQGFRRKHLFsstEN
S357-p	FRRKHLFsstENLAA
S358-p	RRKHLFsstENLAAR
T359-p	RKHLFsstENLAARs
S366-p	tENLAARsPKEPGEG
S383-p	TSSDRRLsDSStkDS
S385	SDRRLsDSStkDSMK
T387-p	RRLsDSStkDSMKSM
K388-a	RLsDSStkDSMKSMs
S390	sDSStkDSMKSMsLP
S395-p	kDSMKSMsLPSYRPL
S398	MKSMsLPSYRPLTSG
Y399	KSMsLPSYRPLTSGD
S434-p	KQESKKSsLLSLVTG
S437	SKKSsLLSLVTGKRD
T440	SsLLSLVTGKRDAAA
K442	LLSLVTGKRDAAAKG
-	gap
P483	EEDLMRRPEKDALPV
A487	MRRPEKDALPVASQW
S492	KDALPVASQWGSSLN
S496	PVASQWGSSLNPFED
S497	VASQWGSSLNPFEDV
S515	DPGATTESRSEPKPP
S517	GATTESRSEPKPPVP
S541-p	VKPRLEVsPEAQPKA
S552-p	QPKARLPsPDSALFA
S629-p	LLLRAVPsLtPAANt
T631-p	LRAVPsLtPAANtGS
T636-p	sLtPAANtGSSASGS
T650	SPCEQLPTPVRKGTE
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
G727	GMHQNASGGQKKGKK
K730	QNASGGQKKGKKRVS
S780-p	GSVLRAGsPESPHTE
T789-p	ESPHTEGtGQEPVTA
-	gap
S881-p	PSIPEVAsDDERVDE
S1018	KQATADVSTSRAENF
T1070	KPMNTTATKIANSSL
K1094-u	LISEALMkKYQPSDP
K1095	ISEALMkKYQPSDPA
Q1097	EALMkKYQPSDPAFA
S1099	LMkKYQPSDPAFAYA
T1109	AFAYAQLTHDELIQL
K1119	ELIQLVLKQKETISK
A1157	PNILRVPAQMGKKAG

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