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Protein Page:
Rab11FIP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rab11FIP1 A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo. Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Chromosomal Location of Human Ortholog: 8p11.22
Cellular Component: phagocytic vesicle membrane; recycling endosome; intracellular membrane-bound organelle; cytoplasm
Molecular Function: Rab GTPase binding
Biological Process: regulated secretory pathway; protein transport
Reference #:  Q6WKZ4 (UniProtKB)
Alt. Names/Synonyms: DKFZp686E2214; FLJ22524; FLJ22622; MGC78448; NOEL1A; Rab effector protein; Rab-coupling protein; Rab-interacting recycling protein; RAB11 coupling protein; RAB11 family interacting protein 1 (class I); Rab11 family-interacting protein 1; Rab11-FIP1; RAB11FIP1; RCP; RFIP1
Gene Symbols: RAB11FIP1
Molecular weight: 137,167 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab11FIP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T684-p ETGTEKNtssLELEE
0 3 S754-p GGDRDLEsQAGsLVE
0 1 K800-ac EMGLNLRkDQkKTKK
0 3 S1214-p EVMMKkYsPsDPAFA
0 1 S625-p VDRGQAKsEGPPLLP
0 1 S647 SLTPVPNSGSSALGS
0 1 K803-ac LNLRkDQkKTKKRVS
0 2 S862 ESPHAEDSERESVTT
0 2 S1135-p KKATAEGsAGRVENF
0 4 S477-p VKPGEDAsGPAEDLV
0 3 S528-p sEPRPPIssPRAPQT
0 3 S758-p DLEsQAGsLVESKAR
0 1 K129-ac KTQWYKLkSkPGKKD
0 1 K131-ac QWYKLkSkPGKKDKE
0 1 T642 ELQTESLTPVPNSGS
0 4 T154-p QFMRNNMtAsMFDLS
0 28 S156-p MRNNMtAsMFDLSMK
0 2 S184-p IKGKNKDsGSDtAsA
0 1 S186 GKNKDsGSDtAsAII
0 1 T188-p NKDsGSDtAsAIIPS
0 2 S190-p DsGSDtAsAIIPSTt
0 1 S195 tAsAIIPSTtPsVDs
0 2 T197-p sAIIPSTtPsVDsDD
0 7 S199-p IIPSTtPsVDsDDEs
0 16 S202-p STtPsVDsDDEsVVK
0 6 S206-p sVDsDDEsVVKDKKK
0 2 T219-p KKKSKIKtLLsKsNL
0 1 S222-p SKIKtLLsKsNLQKt
0 1 S224-p IKtLLsKsNLQKtPL
0 2 T229-p sKsNLQKtPLsQsMs
0 3 S232-p NLQKtPLsQsMsVLP
0 11 S234-p QKtPLsQsMsVLPTs
0 2 S236-p tPLsQsMsVLPTsKP
0 2 S241-p sMsVLPTsKPEKVLL
0 1 S266-p EDDNEDEsSsASDVM
0 1 S268-p DNEDEsSsASDVMSH
0 19 T278-p DVMSHKRtAstDLKQ
0 94 S280-p MSHKRtAstDLKQLN
0 18 T281-p SHKRtAstDLKQLNQ
0 5 T292-p QLNQVNFtLPKKEGL
0 8 S300-p LPKKEGLsFLGGLRS
0 5 S315-p KNDVLSRsNVCINGN
0 11 Y325-p CINGNHVyLEQPEAK
0 1 G333 LEQPEAKGEIKDssP
0 3 S338-p AKGEIKDssPsssPs
0 19 S339-p KGEIKDssPsssPsP
0 11 S341-p EIKDssPsssPsPKG
0 1 S342-p IKDssPsssPsPKGF
0 22 S343-p KDssPsssPsPKGFR
0 29 S345-p ssPsssPsPKGFRKK
0 18 S356-p FRKKHLFsstENLAA
0 44 S357-p RKKHLFsstENLAAG
0 16 T358-p KKHLFsstENLAAGs
0 7 S365-p tENLAAGsWKEPAEG
0 5 S382-p LSSDRQLsEsStKDs
0 2 S384-p SDRQLsEsStKDsLK
0 2 T386-p RQLsEsStKDsLKsM
0 1 K387 QLsEsStKDsLKsMt
0 4 S389-p sEsStKDsLKsMtLP
0 1 S392-p StKDsLKsMtLPsyR
0 3 T394-p KDsLKsMtLPsyRPA
0 2 S397-p LKsMtLPsyRPAPLV
0 2 Y398-p KsMtLPsyRPAPLVS
0 1 S434-p KKPESRRssLLsLMt
0 35 S435-p KPESRRssLLsLMtG
0 4 S438-p SRRssLLsLMtGkKD
0 2 T441-p ssLLsLMtGkKDVAK
0 2 K443-ac LLsLMtGkKDVAKGS
0 1 S487-p AEDLVRRsEKDtAAV
0 1 T491-p VRRsEKDtAAVVsRQ
0 24 S496-p KDtAAVVsRQGssLN
0 98 S500-p AVVsRQGssLNLFED
0 55 S501-p VVsRQGssLNLFEDV
0 3 S519-p EPEAEPEsKsEPRPP
0 4 S521-p EAEPEsKsEPRPPIs
0 1 S640 KAELQTESLTPVPNS
0 4 S660-p GSLFKQPsFPANKGT
0 1 S670-p ANKGTEDsLMGRTRE
0 4 S529-p EPRPPIssPRAPQTR
0 15 S545-p VKPRLEVsPEAQPTA
0 2 S556 QPTARLPSPTDSPSS
0 1 S560 RLPSPTDSPSSLPPL
0 4 - gap
0 1 - gap
0 1 S685-p TGTEKNtssLELEEs
0 1 S686-p GTEKNtssLELEEsL
0 1 S692-p ssLELEEsLPEQPET
0 1 S880-p ATCGAPAsPADHLLL
0 1 S925-p ALVTQYQsKAsDHEG
0 1 S928-p TQYQsKAsDHEGLLs
0 1 S935-p sDHEGLLsDPLSDLQ
0 6 S967-p PSIPEVAsDDERIDQ
0 1 - under review  
0 1 N1093 PPGTSLDNPVPSPSP
0 1 S1154-p PLLQAWVsPSETHPV
0 1 T1187-p KPMNAMAtKVANCsL
0 1 S1193-p AtKVANCsLGtATII
0 1 T1196-p VANCsLGtATIISEN
0 3 K1211 LNNEVMMKkYsPsDP
0 1 K1212-ub NNEVMMKkYsPsDPA
0 1 S1216-p MMKkYsPsDPAFAYA
0 1 T1226-p AFAYAQLtHDELIQL
0 33 T1274-p PNILRIPtQVGKKAG
  Rab11FIP1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S329 VKPGEDASGPAEDLV
S380-p SEPRPPIssPRAPQT
- gap
- gap
- gap
- gap
T6 __MRNNMTASMFDLS
S8 MRNNMTASMFDLSMK
S36 IKGKNKDSGSDTASA
S38 GKNKDSGSDTASAII
T40 NKDSGSDTASAIIPS
S42 DSGSDTASAIIPSTT
S47 TASAIIPSTTPSVDS
T49 SAIIPSTTPSVDSDD
S51 IIPSTTPSVDSDDES
S54 STTPSVDSDDESVVK
S58 SVDSDDESVVKDKKK
T71 KKKSKIKTLLSKSNL
S74 SKIKTLLSKSNLQKT
S76 IKTLLSKSNLQKTPL
T81 SKSNLQKTPLSQSMS
S84 NLQKTPLSQSMSVLP
S86 QKTPLSQSMSVLPTS
S88 TPLSQSMSVLPTSKP
S93 SMSVLPTSKPEKVLL
S118 EDDNEDESSSASDVM
S120 DNEDESSSASDVMSH
T130 DVMSHKRTASTDLKQ
S132 MSHKRTASTDLKQLN
T133 SHKRTASTDLKQLNQ
T144 QLNQVNFTLPKKEGL
S152 LPKKEGLSFLGGLRS
S167 KNDVLSRSNVCINGN
Y177 CINGNHVYLEQPEAK
G185 LEQPEAKGEIKDSSP
S190 AKGEIKDSSPSSSPS
S191 KGEIKDSSPSSSPSP
S193 EIKDSSPSSSPSPKG
S194 IKDSSPSSSPSPKGF
S195 KDSSPSSSPSPKGFR
S197 SSPSSSPSPKGFRKK
S208 FRKKHLFSSTENLAA
S209 RKKHLFSSTENLAAG
T210 KKHLFSSTENLAAGS
S217 TENLAAGSWKEPAEG
S234 LSSDRQLSESSTKDS
S236 SDRQLSESSTKDSLK
T238 RQLSESSTKDSLKSM
K239 QLSESSTKDSLKSMT
S241 SESSTKDSLKSMTLP
S244 STKDSLKSMTLPSYR
T246 KDSLKSMTLPSYRPA
S249 LKSMTLPSYRPAPLV
Y250 KSMTLPSYRPAPLVS
S286 KKPESRRSSLLSLMT
S287 KPESRRSSLLSLMTG
S290 SRRSSLLSLMTGKKD
T293 SSLLSLMTGKKDVAK
K295 LLSLMTGKKDVAKGS
S339 AEDLVRRSEKDTAAV
T343 VRRSEKDTAAVVSRQ
S348 KDTAAVVSRQGSSLN
S352 AVVSRQGSSLNLFED
S353 VVSRQGSSLNLFEDV
S371 EPEAEPESKSEPRPP
S373 EAEPESKSEPRPPIs
- gap
- gap
- gap
S381-p EPRPPIssPRAPQTR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- under review  
- gap
T405 KPMNAMATKVANCSL
S411 ATKVANCSLGTATII
T414 VANCSLGTATIISEN
K429 LNNEVMMKVCPLRSW
- gap
- gap
- gap
- gap
  mouse

 
- gap
- gap
- gap
- gap
A617 TGQGEADAEKPSLLL
T636-p sLtPAANtGSSASGS
K730 QNASGGQKKGKKRVS
T789-p ESPHtEGtGQEPVTA
S1018 KQATADVSTSRAENF
- gap
- gap
- gap
K131 KKQWYTLKSKPGKKD
K133 QWYTLKSKPGKKDKE
T631-p LRAVPsLtPAANtGS
T156 QFMRNNMTAsMFDLS
S158-p MRNNMTAsMFDLSMK
S186-p IKGKNKDsAsDtAsA
S188-p GKNKDsAsDtAsAIV
T190-p NKDsAsDtAsAIVPs
S192-p DsAsDtAsAIVPsVt
S197-p tAsAIVPsVtPsVDs
T199-p sAIVPsVtPsVDsDD
S201-p IVPsVtPsVDsDDEs
S204-p sVtPsVDsDDEsFSK
S208-p sVDsDDEsFSKDKKK
T221 KKKSKIKTLFSKSSL
S224 SKIKTLFSKSSLQKT
S226 IKTLFSKSSLQKTPL
T231 SKSSLQKTPLsQsMs
S234-p SLQKTPLsQsMsVLP
S236-p QKTPLsQsMsVLPTS
S238-p TPLsQsMsVLPTSKS
S243 sMsVLPTSKSDKVLL
S268 DDAHEDESSSASDVM
S270 AHEDESSSASDVMSH
T280-p DVMSHKRtSstDQQP
S282-p MSHKRtSstDQQPNQ
T283-p SHKRtSstDQQPNQS
S293 QPNQSNFSLPKKEGL
S301 LPKKEGLSFLGGLRS
S316-p KNDSLSRsTVCINGN
Y326 CINGNHVYMEQPEAR
S334-p MEQPEARsEIREssP
S339-p ARsEIREssPsNsPs
S340-p RsEIREssPsNsPsP
S342-p EIREssPsNsPsPQG
N343 IREssPsNsPsPQGF
S344-p REssPsNsPsPQGFR
S346-p ssPsNsPsPQGFRRK
S357-p FRRKHLFsstENLAA
S358-p RRKHLFsstENLAAR
T359-p RKHLFsstENLAARs
S366-p tENLAARsPKEPGEG
S383-p TSSDRRLsDSStkDS
S385 SDRRLsDSStkDSMK
T387-p RRLsDSStkDSMKSM
K388-ac RLsDSStkDSMKSMs
S390 sDSStkDSMKSMsLP
S393 StkDSMKSMsLPSYR
S395-p kDSMKSMsLPSYRPL
S398 MKSMsLPSYRPLTSG
Y399 KSMsLPSYRPLTSGD
S433 KKQESKKSsLLSLVT
S434-p KQESKKSsLLSLVTG
S437 SKKSsLLSLVTGKRD
T440 SsLLSLVTGKRDAAA
K442 LLSLVTGKRDAAAKG
P483 EEDLMRRPEKDALPV
A487 MRRPEKDALPVASQW
S492 KDALPVASQWGSSLN
S496 PVASQWGSSLNPFED
S497 VASQWGSSLNPFEDV
S515 DPGATTESRSEPKPP
S517 GATTESRSEPKPPVP
S629-p LLLRAVPsLtPAANt
T650 SPCEQLPTPVRKGTE
S660 RKGTEEASGDTRKEA
- gap
S541-p VKPRLEVsPEAQPKA
S552-p QPKARLPsPDsALFA
S555-p ARLPsPDsALFAPFP
S780-p GSVLRAGsPESPHtE
T786-p GsPESPHtEGtGQEP
- gap
S669 DTRKEAGSDESGKTL
T675 GSDESGKTLMTECVS
- gap
S839 DLMAPCQSKASDHEG
S842 APCQSKASDHEGLLS
S849 SDHEGLLSNPLSDLP
S881-p PSIPEVAsDDERVDE
- under review  
- under review  
T1037 PLLQAWVTPSEIHPT
T1070 KPMNTTATKIANSSL
S1076 ATKIANSSLGTATII
T1079 IANSSLGTATIITEN
K1094-ub LISEALMkKYQPSDP
K1095 ISEALMkKYQPSDPA
S1099 LMkKYQPSDPAFAYA
T1109 AFAYAQLTHDELIQL
A1157 PNILRVPAQMGKKAG
  rat

► Hide Isoforms
 
- gap
- gap
- gap
- gap
A620 TDKGEADAEEPSLLL
A639 SVTPAANAGSSASRS
R742 QNASGGQRKAKKRVS
T801 ESPHTEGTGQEPVTI
S1041 KQATADVSSNRVENF
- gap
- gap
- gap
K132 KKQWYTLKSKPGKKD
K134 QWYTLKSKPGKKDKE
T634 LRAISSVTPAANAGS
T157 QFMRNNMTAsMFDLS
S159-p MRNNMTAsMFDLSMK
N187 IKGKNKDNTSDTASA
S189 GKNKDNTSDTASAIV
T191 NKDNTSDTASAIVPS
S193 DNTSDTASAIVPSTT
S198 TASAIVPSTTPSVDs
T200 SAIVPSTTPSVDsDD
S202 IVPSTTPSVDsDDES
S205-p STTPSVDsDDESFSK
S209 SVDsDDESFSKDKKK
T222 KKKSKIKTLFSKPSL
S225 SKIKTLFSKPSLQKT
P227 IKTLFSKPSLQKTPL
T232 SKPSLQKTPLSQSMS
S235 SLQKTPLSQSMSVLP
S237 QKTPLSQSMSVLPTS
S239 TPLSQSMSVLPTSKP
S244 SMSVLPTSKPDKVLL
S270 EGDNEDESSSASEVM
S272 DNEDESSSASEVMSQ
T282 EVMSQKRTSSTDHTQ
S284 MSQKRTSSTDHTQPN
T285 SQKRTSSTDHTQPNQ
S296 QPNQSNFSLPKKEGL
S304 LPKKEGLSFLGGLRS
S319 KNDSLSRSNVCINGN
Y329 CINGNHVYMEQPEAK
S337 MEQPEAKSEIRESsP
S342 AKSEIRESsPSNsPs
S343-p KSEIRESsPSNsPsP
S345 EIRESsPSNsPsPQG
N346 IRESsPSNsPsPQGF
S347-p RESsPSNsPsPQGFR
S349-p SsPSNsPsPQGFRKR
S360 FRKRHLFSsTENLAA
S361-p RKRHLFSsTENLAAR
T362 KRHLFSsTENLAARS
S369 TENLAARSPKEPGEG
S386-p MSSDRRLsDSSTKDS
S388 SDRRLsDSSTKDSMK
T390 RRLsDSSTKDSMKSM
K391 RLsDSSTKDSMKSMS
S393 sDSSTKDSMKSMSLP
S396 STKDSMKSMSLPSYR
S398 KDSMKSMSLPSYRPL
S401 MKSMSLPSYRPLTTA
Y402 KSMSLPSYRPLTTAD
S437 KKQESKKSSLLSLVT
S438 KQESKKSSLLSLVTG
S441 SKKSSLLSLVTGKKD
T444 SSLLSLVTGKKDVAK
K446 LLSLVTGKKDVAKGS
P486 EEDLVRRPEKDAVPV
A490 VRRPEKDAVPVASQW
S495 KDAVPVASQWGSSQN
S499 PVASQWGSSQNPFED
S500 VASQWGSSQNPFEDA
S518 DLEASVESKCEPKPP
C520 EASVESKCEPKPPVP
S632 LLLRAISSVTPAANA
T653 SPCEQLPTPERKGPQ
S663 RKGPQESSGGKARES
- gap
S544-p VKPRLEVsPEAQPKA
S555 QPKARLPSSDSAPFA
S558 ARLPSSDSAPFAAFL
S792 SSMPSAGSPESPHTE
T798 GSPESPHTEGTGQEP
- gap
S678 GTGKEVGSDESEKSL
S684 GSDESEKSLIGQHEE
- gap
S845 DLMAPCQSKASDHEG
S848 APCQSKASDHEGLLS
S855 SDHEGLLSNPLSDLP
S887-p PSIPEVAsDDERFDE
S995-p KGSGRPGsPLDsPVR
S999-p RPGsPLDsPVRSPSL
T1060 PLLQAWVTPSEIHPV
T1096 NTTAPKITNSSLGTA
S1099 APKITNSSLGTATII
T1102 ITNSSLGTATIISEN
K1117 LINEALMKKYQPSDP
K1118 INEALMKKYQPSDPA
S1122 LMKKYQPSDPAFAYA
T1132 AFAYAQLTHDELIQL
A1180 PNILRVPAQTGKKAG
  Rab11FIP1 iso7  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K132 KKQWYTLKSKPGKKD
K134 QWYTLKSKPGKKDKE
- gap
T157 QFMRNNMTASMFDLS
S159 MRNNMTASMFDLSMK
N187 IKGKNKDNTSDTASA
S189 GKNKDNTSDTASAIV
T191 NKDNTSDTASAIVPS
S193 DNTSDTASAIVPSTT
S198 TASAIVPSTTPSVDS
T200 SAIVPSTTPSVDSDD
S202 IVPSTTPSVDSDDES
S205 STTPSVDSDDESFSK
S209 SVDSDDESFSKDKKK
T222 KKKSKIKTLFSKPSL
S225 SKIKTLFSKPSLQKT
P227 IKTLFSKPSLQKTPL
T232 SKPSLQKTPLSQSMS
S235 SLQKTPLSQSMSVLP
S237 QKTPLSQSMSVLPTS
S239 TPLSQSMSVLPTSKP
S244 SMSVLPTSKPDKVLL
S270 EGDNEDESSSASEVM
S272 DNEDESSSASEVMSQ
T282 EVMSQKRTSSTDHTQ
S284 MSQKRTSSTDHTQPN
T285 SQKRTSSTDHTQPNQ
S296 QPNQSNFSLPKKEGL
S304 LPKKEGLSFLGGLRS
S319 KNDSLSRSNVCINGN
Y329 CINGNHVYMEQPEAK
S337 MEQPEAKSEIRESSP
S342 AKSEIRESSPSNSPS
S343 KSEIRESSPSNSPSP
S345 EIRESSPSNSPSPQG
N346 IRESSPSNSPSPQGF
S347 RESSPSNSPSPQGFR
S349 SSPSNSPSPQGFRKR
S360 FRKRHLFSSTENLAA
S361 RKRHLFSSTENLAAR
T362 KRHLFSSTENLAARS
S369 TENLAARSPKEPGEG
S386 MSSDRRLSDSSTKDS
S388 SDRRLSDSSTKDSMK
T390 RRLSDSSTKDSMKSM
K391 RLSDSSTKDSMKSMS
S393 SDSSTKDSMKSMSLP
S396 STKDSMKSMSLPSYR
S398 KDSMKSMSLPSYRPL
S401 MKSMSLPSYRPLTTA
Y402 KSMSLPSYRPLTTAD
S437 KKQESKKSSLLSLVT
S438 KQESKKSSLLSLVTG
S441 SKKSSLLSLVTGKKD
T444 SSLLSLVTGKKDVAK
K446 LLSLVTGKKDVAKGS
P486 EEDLVRRPEKDAVPV
A490 VRRPEKDAVPVASQW
S495 KDAVPVASQWGSSQN
S499 PVASQWGSSQNPFED
S500 VASQWGSSQNPFEDA
S518 DLEASVESKCEPKPP
C520 EASVESKCEPKPPVP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- under review  
- gap
T555 NTTAPKITNSSLGTA
S558 APKITNSSLGTATII
T561 ITNSSLGTATIISEN
K576 LINEALMKKYQPSDP
K577 INEALMKKYQPSDPA
S581 LMKKYQPSDPAFAYA
T591 AFAYAQLTHDELIQL
A639 PNILRVPAQTGKKAG
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