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Protein Page:
Rab11FIP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Rab11FIP1 A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo. Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: recycling endosome; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm
Biological Process: protein transport
Reference #:  Q6WKZ4 (UniProtKB)
Alt. Names/Synonyms: DKFZp686E2214; FLJ22524; FLJ22622; MGC78448; NOEL1A; Rab effector protein; Rab-coupling protein; Rab-interacting recycling protein; RAB11 coupling protein; RAB11 family interacting protein 1 (class I); Rab11 family-interacting protein 1; Rab11-FIP1; RAB11FIP1; RCP; RFIP1
Gene Symbols: RAB11FIP1
Molecular weight: 137,195 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab11FIP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 T154-p QFMRNNMtAsMFDLS
0 18 S156-p MRNNMtAsMFDLSMK
0 1 S184-p IKGKNKDsGSDTASA
0 1 S186 GKNKDsGSDTASAII
0 1 S190 DsGSDTASAIIPSTt
0 1 S195 TASAIIPSTtPsVDs
0 2 T197-p SAIIPSTtPsVDsDD
0 4 S199-p IIPSTtPsVDsDDEs
0 11 S202-p STtPsVDsDDEsVVK
0 3 S206-p sVDsDDEsVVKDKKK
0 1 T219-p KKKSKIKtLLsKSNL
0 1 S222-p SKIKtLLsKSNLQKT
0 1 S232-p NLQKTPLsQsMsVLP
0 7 S234-p QKTPLsQsMsVLPTS
0 1 S236-p TPLsQsMsVLPTSKP
0 19 T278-p DVMSHKRtAstDLKQ
0 93 S280-p MSHKRtAstDLKQLN
0 18 T281-p SHKRtAstDLKQLNQ
0 1 T292-p QLNQVNFtLPKKEGL
0 5 S300-p LPKKEGLsFLGGLRS
0 2 S315-p KNDVLSRsNVCINGN
0 11 Y325-p CINGNHVyLEQPEAK
0 1 G333 LEQPEAKGEIKDssP
0 2 S338-p AKGEIKDssPsssPs
0 15 S339-p KGEIKDssPsssPsP
0 11 S341-p EIKDssPsssPsPKG
0 1 S342-p IKDssPsssPsPKGF
0 17 S343-p KDssPsssPsPKGFR
0 23 S345-p ssPsssPsPKGFRKK
0 13 S356-p FRKKHLFsstENLAA
0 36 S357-p RKKHLFsstENLAAG
0 14 T358-p KKHLFsstENLAAGs
0 6 S365-p tENLAAGsWKEPAEG
0 4 S382-p LSSDRQLsESStKDs
0 2 T386-p RQLsESStKDsLKSM
0 3 S389-p sESStKDsLKSMtLP
0 2 T394-p KDsLKSMtLPsyRPA
0 2 S397-p LKSMtLPsyRPAPLV
0 2 Y398-p KSMtLPsyRPAPLVS
0 27 S435-p KPESRRSsLLsLMtG
0 2 S438-p SRRSsLLsLMtGkKD
0 2 T441-p SsLLsLMtGkKDVAK
0 2 K443-a LLsLMtGkKDVAKGS
0 2 S477-p VKPGEDAsGPAEDLV
0 23 S496-p KDTAAVVsRQGssLN
0 96 S500-p AVVsRQGssLNLFED
0 53 S501-p VVsRQGssLNLFEDV
0 3 S519-p EPEAEPEsKsEPRPP
0 3 S521-p EAEPEsKsEPRPPIs
0 2 S528-p sEPRPPIssPRAPQT
0 1 S529-p EPRPPIssPRAPQTR
0 10 S545-p VKPRLEVsPEAQPTA
0 1 S556 QPTARLPSPTDSPSS
0 3 S660-p GSLFKQPsFPANKGT
0 1 T684-p ETGTEKNtssLELEE
0 1 S685-p TGTEKNtssLELEEs
0 1 S686-p GTEKNtssLELEEsL
0 1 S692-p ssLELEEsLPEQPET
0 1 S754-p GGDRDLEsQAGsLVE
0 1 S758-p DLEsQAGsLVESKAR
0 1 K800-a EMGLNLRkDQkKTKK
0 1 K803-a LNLRkDQkKTKKRVS
0 4 - gap
0 1 S862 ESPHAEDSERESVTT
0 6 S967-p PSIPEVAsDDERIDQ
0 1 S1135-p KKATAEGsAGRVENF
0 3 K1211 LNNEVMMKkYsPSDP
0 1 K1212-u NNEVMMKkYsPSDPA
0 2 S1214-p EVMMKkYsPSDPAFA
0 33 T1274-p PNILRIPtQVGKKAG
  mouse

 
T156 QFMRNNMTAsMFDLS
S158-p MRNNMTAsMFDLSMK
S186-p IKGKNKDsAsDTAsA
S188-p GKNKDsAsDTAsAIV
S192-p DsAsDTAsAIVPsVt
S197-p TAsAIVPsVtPsVDs
T199-p sAIVPsVtPsVDsDD
S201-p IVPsVtPsVDsDDEs
S204-p sVtPsVDsDDEsFSK
S208-p sVDsDDEsFSKDKKK
T221 KKKSKIKTLFSKSSL
S224 SKIKTLFSKSSLQKT
S234-p SLQKTPLsQsMsVLP
S236-p QKTPLsQsMsVLPTS
S238-p TPLsQsMsVLPTSKS
T280-p DVMSHKRtSstDQQP
S282-p MSHKRtSstDQQPNQ
T283-p SHKRtSstDQQPNQS
S293 QPNQSNFSLPKKEGL
S301 LPKKEGLSFLGGLRS
S316-p KNDSLSRsTVCINGN
Y326 CINGNHVYMEQPEAR
S334-p MEQPEARsEIREssP
S339-p ARsEIREssPsNsPs
S340-p RsEIREssPsNsPsP
S342-p EIREssPsNsPsPQG
N343 IREssPsNsPsPQGF
S344-p REssPsNsPsPQGFR
S346-p ssPsNsPsPQGFRRK
S357-p FRRKHLFsstENLAA
S358-p RRKHLFsstENLAAR
T359-p RKHLFsstENLAARs
S366-p tENLAARsPKEPGEG
S383-p TSSDRRLsDSStKDS
T387-p RRLsDSStKDSMKSM
S390 sDSStKDSMKSMsLP
S395-p KDSMKSMsLPSYRPL
S398 MKSMsLPSYRPLTSG
Y399 KSMsLPSYRPLTSGD
S434-p KQESKKSsLLSLVTG
S437 SKKSsLLSLVTGKRD
T440 SsLLSLVTGKRDAAA
K442 LLSLVTGKRDAAAKG
- gap
S492 KDALPVASQWGSSLN
S496 PVASQWGSSLNPFED
S497 VASQWGSSLNPFEDV
S515 DPGATTESRSEPKPP
S517 GATTESRSEPKPPVP
- gap
- gap
S541-p VKPRLEVsPEAQPKA
S552-p QPKARLPsPDSALFA
T650 SPCEQLPTPVRKGTE
- gap
- gap
S669 DTRKEAGSDESGKTL
T675 GSDESGKTLMTECVS
- gap
- gap
- gap
K730 QNASGGQKKGKKRVS
S780-p GSVLRAGsPESPHTE
T789-p ESPHTEGtGQEPVTA
S881-p PSIPEVAsDDERVDE
S1018 KQATADVSTSRAENF
K1094-u LISEALMkKYQPSDP
K1095 ISEALMkKYQPSDPA
- gap
- gap
  rat

► Hide Isoforms
 
T157 QFMRNNMTASMFDLS
S159 MRNNMTASMFDLSMK
N187 IKGKNKDNTSDTASA
S189 GKNKDNTSDTASAIV
S193 DNTSDTASAIVPSTT
S198 TASAIVPSTTPSVDs
T200 SAIVPSTTPSVDsDD
S202 IVPSTTPSVDsDDES
S205-p STTPSVDsDDESFSK
S209 SVDsDDESFSKDKKK
T222 KKKSKIKTLFSKPSL
S225 SKIKTLFSKPSLQKT
S235 SLQKTPLSQSMSVLP
S237 QKTPLSQSMSVLPTS
S239 TPLSQSMSVLPTSKP
T282 EVMSQKRTSSTDHTQ
S284 MSQKRTSSTDHTQPN
T285 SQKRTSSTDHTQPNQ
S296 QPNQSNFSLPKKEGL
S304 LPKKEGLSFLGGLRS
S319 KNDSLSRSNVCINGN
Y329 CINGNHVYMEQPEAK
S337 MEQPEAKSEIRESSP
S342 AKSEIRESSPSNSPs
S343 KSEIRESSPSNSPsP
S345 EIRESSPSNSPsPQG
N346 IRESSPSNSPsPQGF
S347 RESSPSNSPsPQGFR
S349-p SSPSNSPsPQGFRKR
S360 FRKRHLFSSTENLAA
S361 RKRHLFSSTENLAAR
T362 KRHLFSSTENLAARS
S369 TENLAARSPKEPGEG
S386 MSSDRRLSDSSTKDS
T390 RRLSDSSTKDSMKSM
S393 SDSSTKDSMKSMSLP
S398 KDSMKSMSLPSYRPL
S401 MKSMSLPSYRPLTTA
Y402 KSMSLPSYRPLTTAD
S438 KQESKKSSLLSLVTG
S441 SKKSSLLSLVTGKKD
T444 SSLLSLVTGKKDVAK
K446 LLSLVTGKKDVAKGS
- gap
S495 KDAVPVASQWGSSQN
S499 PVASQWGSSQNPFED
S500 VASQWGSSQNPFEDA
S518 DLEASVESKCEPKPP
- gap
- gap
- gap
S544-p VKPRLEVsPEAQPKA
S555 QPKARLPSSDSAPFA
T653 SPCEQLPTPERKGPQ
- gap
- gap
S678 GTGKEVGSDESEKSL
S684 GSDESEKSLIGQHEE
- gap
- gap
- gap
R742 QNASGGQRKAKKRVS
S792 SSMPSAGSPESPHTE
T801 ESPHTEGTGQEPVTI
S887-p PSIPEVAsDDERFDE
S1041 KQATADVSSNRVENF
K1117 LINEALMKKYQPSDP
K1118 INEALMKKYQPSDPA
- gap
- gap
  Rab11FIP1 iso7  
T157 QFMRNNMTASMFDLS
S159 MRNNMTASMFDLSMK
N187 IKGKNKDNTSDTASA
S189 GKNKDNTSDTASAIV
S193 DNTSDTASAIVPSTT
S198 TASAIVPSTTPSVDS
T200 SAIVPSTTPSVDSDD
S202 IVPSTTPSVDSDDES
S205 STTPSVDSDDESFSK
S209 SVDSDDESFSKDKKK
T222 KKKSKIKTLFSKPSL
S225 SKIKTLFSKPSLQKT
S235 SLQKTPLSQSMSVLP
S237 QKTPLSQSMSVLPTS
S239 TPLSQSMSVLPTSKP
T282 EVMSQKRTSSTDHTQ
S284 MSQKRTSSTDHTQPN
T285 SQKRTSSTDHTQPNQ
S296 QPNQSNFSLPKKEGL
S304 LPKKEGLSFLGGLRS
S319 KNDSLSRSNVCINGN
Y329 CINGNHVYMEQPEAK
S337 MEQPEAKSEIRESSP
S342 AKSEIRESSPSNSPS
S343 KSEIRESSPSNSPSP
S345 EIRESSPSNSPSPQG
N346 IRESSPSNSPSPQGF
S347 RESSPSNSPSPQGFR
S349 SSPSNSPSPQGFRKR
S360 FRKRHLFSSTENLAA
S361 RKRHLFSSTENLAAR
T362 KRHLFSSTENLAARS
S369 TENLAARSPKEPGEG
S386 MSSDRRLSDSSTKDS
T390 RRLSDSSTKDSMKSM
S393 SDSSTKDSMKSMSLP
S398 KDSMKSMSLPSYRPL
S401 MKSMSLPSYRPLTTA
Y402 KSMSLPSYRPLTTAD
S438 KQESKKSSLLSLVTG
S441 SKKSSLLSLVTGKKD
T444 SSLLSLVTGKKDVAK
K446 LLSLVTGKKDVAKGS
- gap
S495 KDAVPVASQWGSSQN
S499 PVASQWGSSQNPFED
S500 VASQWGSSQNPFEDA
S518 DLEASVESKCEPKPP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K576 LINEALMKKYQPSDP
K577 INEALMKKYQPSDPA
- gap
- gap
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