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Protein Page:
Rab11FIP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rab11FIP1 A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo. Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: recycling endosome; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm
Biological Process: protein transport
Reference #:  Q6WKZ4 (UniProtKB)
Alt. Names/Synonyms: DKFZp686E2214; FLJ22524; FLJ22622; MGC78448; NOEL1A; Rab effector protein; Rab-coupling protein; Rab-interacting recycling protein; RAB11 coupling protein; RAB11 family interacting protein 1 (class I); Rab11 family-interacting protein 1; Rab11-FIP1; RAB11FIP1; RCP; RFIP1
Gene Symbols: RAB11FIP1
Molecular weight: 137,167 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab11FIP1

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K129-ac KTQWYKLkSkPGKKD
0 1 K131-ac QWYKLkSkPGKKDKE
0 4 T154-p QFMRNNMtAsMFDLS
0 21 S156-p MRNNMtAsMFDLSMK
0 2 S184-p IKGKNKDsGSDtAsA
0 1 S186 GKNKDsGSDtAsAII
0 1 T188-p NKDsGSDtAsAIIPS
0 2 S190-p DsGSDtAsAIIPSTt
0 1 S195 tAsAIIPSTtPsVDs
0 2 T197-p sAIIPSTtPsVDsDD
0 5 S199-p IIPSTtPsVDsDDEs
0 12 S202-p STtPsVDsDDEsVVK
0 4 S206-p sVDsDDEsVVKDKKK
0 2 T219-p KKKSKIKtLLsKsNL
0 1 S222-p SKIKtLLsKsNLQKt
0 1 S224-p IKtLLsKsNLQKtPL
0 1 T229-p sKsNLQKtPLsQsMs
0 3 S232-p NLQKtPLsQsMsVLP
0 10 S234-p QKtPLsQsMsVLPTs
0 1 S236-p tPLsQsMsVLPTsKP
0 1 S241-p sMsVLPTsKPEKVLL
0 1 S266-p EDDNEDEsSsASDVM
0 1 S268-p DNEDEsSsASDVMSH
0 19 T278-p DVMSHKRtAstDLKQ
0 94 S280-p MSHKRtAstDLKQLN
0 18 T281-p SHKRtAstDLKQLNQ
0 1 T292-p QLNQVNFtLPKKEGL
0 6 S300-p LPKKEGLsFLGGLRS
0 4 S315-p KNDVLSRsNVCINGN
0 11 Y325-p CINGNHVyLEQPEAK
0 1 G333 LEQPEAKGEIKDssP
0 2 S338-p AKGEIKDssPsssPs
0 16 S339-p KGEIKDssPsssPsP
0 11 S341-p EIKDssPsssPsPKG
0 1 S342-p IKDssPsssPsPKGF
0 18 S343-p KDssPsssPsPKGFR
0 25 S345-p ssPsssPsPKGFRKK
0 16 S356-p FRKKHLFsstENLAA
0 38 S357-p RKKHLFsstENLAAG
0 15 T358-p KKHLFsstENLAAGs
0 7 S365-p tENLAAGsWKEPAEG
0 4 S382-p LSSDRQLsEsStKDs
0 1 S384-p SDRQLsEsStKDsLK
0 2 T386-p RQLsEsStKDsLKSM
0 1 K387 QLsEsStKDsLKSMt
0 3 S389-p sEsStKDsLKSMtLP
0 3 T394-p KDsLKSMtLPsyRPA
0 2 S397-p LKSMtLPsyRPAPLV
0 2 Y398-p KSMtLPsyRPAPLVS
0 30 S435-p KPESRRSsLLsLMtG
0 3 S438-p SRRSsLLsLMtGkKD
0 2 T441-p SsLLsLMtGkKDVAK
0 2 K443-ac LLsLMtGkKDVAKGS
0 3 S477-p VKPGEDAsGPAEDLV
0 1 S487-p AEDLVRRsEKDtAAV
0 1 T491-p VRRsEKDtAAVVsRQ
0 24 S496-p KDtAAVVsRQGssLN
0 97 S500-p AVVsRQGssLNLFED
0 54 S501-p VVsRQGssLNLFEDV
0 3 S519-p EPEAEPEsKsEPRPP
0 3 S521-p EAEPEsKsEPRPPIs
0 2 S528-p sEPRPPIssPRAPQT
0 3 S529-p EPRPPIssPRAPQTR
0 12 S545-p VKPRLEVsPEAQPTA
0 2 S556 QPTARLPSPTDSPSS
0 1 S560 RLPSPTDSPSSLPPL
0 1 S640 KAELQTESLTPVPNS
0 1 T642 ELQTESLTPVPNSGS
0 1 S647 SLTPVPNSGSSALGS
0 3 S660-p GSLFKQPsFPANKGT
0 1 S670-p ANKGTEDsLMGRTRE
0 1 T684-p ETGTEKNtssLELEE
0 1 S685-p TGTEKNtssLELEEs
0 1 S686-p GTEKNtssLELEEsL
0 1 S692-p ssLELEEsLPEQPET
0 2 S754-p GGDRDLEsQAGsLVE
0 2 S758-p DLEsQAGsLVESKAR
0 1 K800-ac EMGLNLRkDQkKTKK
0 1 K803-ac LNLRkDQkKTKKRVS
0 4 - gap
0 1 - gap
0 2 S862 ESPHAEDSERESVTT
0 1 S880-p ATCGAPAsPADHLLL
0 6 S967-p PSIPEVAsDDERIDQ
0 1 S1135-p KKATAEGsAGRVENF
0 1 T1187-p KPMNAMAtKVANCsL
0 1 S1193-p AtKVANCsLGtATII
0 1 T1196-p VANCsLGtATIISEN
0 3 K1211 LNNEVMMKkYsPsDP
0 1 K1212-ub NNEVMMKkYsPsDPA
0 2 S1214-p EVMMKkYsPsDPAFA
0 1 S1216-p MMKkYsPsDPAFAYA
0 1 T1226-p AFAYAQLtHDELIQL
0 1 K1236-ub ELIQLVLkQKETISK
0 33 T1274-p PNILRIPtQVGKKAG
  mouse

 
K131 KKQWYTLKSKPGKKD
K133 QWYTLKSKPGKKDKE
T156 QFMRNNMTAsMFDLS
S158-p MRNNMTAsMFDLSMK
S186-p IKGKNKDsAsDtAsA
S188-p GKNKDsAsDtAsAIV
T190-p NKDsAsDtAsAIVPs
S192-p DsAsDtAsAIVPsVt
S197-p tAsAIVPsVtPsVDs
T199-p sAIVPsVtPsVDsDD
S201-p IVPsVtPsVDsDDEs
S204-p sVtPsVDsDDEsFSK
S208-p sVDsDDEsFSKDKKK
T221 KKKSKIKTLFSKSSL
S224 SKIKTLFSKSSLQKT
S226 IKTLFSKSSLQKTPL
T231 SKSSLQKTPLsQsMs
S234-p SLQKTPLsQsMsVLP
S236-p QKTPLsQsMsVLPTS
S238-p TPLsQsMsVLPTSKS
S243 sMsVLPTSKSDKVLL
S268 DDAHEDESSSASDVM
S270 AHEDESSSASDVMSH
T280-p DVMSHKRtSstDQQP
S282-p MSHKRtSstDQQPNQ
T283-p SHKRtSstDQQPNQS
S293 QPNQSNFSLPKKEGL
S301 LPKKEGLSFLGGLRS
S316-p KNDSLSRsTVCINGN
Y326 CINGNHVYMEQPEAR
S334-p MEQPEARsEIREssP
S339-p ARsEIREssPsNsPs
S340-p RsEIREssPsNsPsP
S342-p EIREssPsNsPsPQG
N343 IREssPsNsPsPQGF
S344-p REssPsNsPsPQGFR
S346-p ssPsNsPsPQGFRRK
S357-p FRRKHLFsstENLAA
S358-p RRKHLFsstENLAAR
T359-p RKHLFsstENLAARs
S366-p tENLAARsPKEPGEG
S383-p TSSDRRLsDSStkDS
S385 SDRRLsDSStkDSMK
T387-p RRLsDSStkDSMKSM
K388-ac RLsDSStkDSMKSMs
S390 sDSStkDSMKSMsLP
S395-p kDSMKSMsLPSYRPL
S398 MKSMsLPSYRPLTSG
Y399 KSMsLPSYRPLTSGD
S434-p KQESKKSsLLSLVTG
S437 SKKSsLLSLVTGKRD
T440 SsLLSLVTGKRDAAA
K442 LLSLVTGKRDAAAKG
- gap
P483 EEDLMRRPEKDALPV
A487 MRRPEKDALPVASQW
S492 KDALPVASQWGSSLN
S496 PVASQWGSSLNPFED
S497 VASQWGSSLNPFEDV
S515 DPGATTESRSEPKPP
S517 GATTESRSEPKPPVP
- gap
- gap
S541-p VKPRLEVsPEAQPKA
S552-p QPKARLPsPDsALFA
S555-p ARLPsPDsALFAPFP
S629-p LLLRAVPsLtPAANt
T631-p LRAVPsLtPAANtGS
T636-p sLtPAANtGSSASGS
T650 SPCEQLPTPVRKGTE
S660 RKGTEEASGDTRKEA
- gap
- gap
S669 DTRKEAGSDESGKTL
T675 GSDESGKTLMTECVS
- gap
- gap
- gap
K730 QNASGGQKKGKKRVS
S780-p GSVLRAGsPESPHtE
T786-p GsPESPHtEGtGQEP
T789-p ESPHtEGtGQEPVTA
- gap
S881-p PSIPEVAsDDERVDE
S1018 KQATADVSTSRAENF
T1070 KPMNTTATKIANSSL
S1076 ATKIANSSLGTATII
T1079 IANSSLGTATIITEN
K1094-ub LISEALMkKYQPSDP
K1095 ISEALMkKYQPSDPA
- gap
S1099 LMkKYQPSDPAFAYA
T1109 AFAYAQLTHDELIQL
K1119 ELIQLVLKQKETISK
- gap
  rat

► Hide Isoforms
 
K132 KKQWYTLKSKPGKKD
K134 QWYTLKSKPGKKDKE
T157 QFMRNNMTASMFDLS
S159 MRNNMTASMFDLSMK
N187 IKGKNKDNTSDTASA
S189 GKNKDNTSDTASAIV
T191 NKDNTSDTASAIVPS
S193 DNTSDTASAIVPSTT
S198 TASAIVPSTTPSVDs
T200 SAIVPSTTPSVDsDD
S202 IVPSTTPSVDsDDES
S205-p STTPSVDsDDESFSK
S209 SVDsDDESFSKDKKK
T222 KKKSKIKTLFSKPSL
S225 SKIKTLFSKPSLQKT
P227 IKTLFSKPSLQKTPL
T232 SKPSLQKTPLSQSMS
S235 SLQKTPLSQSMSVLP
S237 QKTPLSQSMSVLPTS
S239 TPLSQSMSVLPTSKP
S244 SMSVLPTSKPDKVLL
S270 EGDNEDESSSASEVM
S272 DNEDESSSASEVMSQ
T282 EVMSQKRTSSTDHTQ
S284 MSQKRTSSTDHTQPN
T285 SQKRTSSTDHTQPNQ
S296 QPNQSNFSLPKKEGL
S304 LPKKEGLSFLGGLRS
S319 KNDSLSRSNVCINGN
Y329 CINGNHVYMEQPEAK
S337 MEQPEAKSEIRESSP
S342 AKSEIRESSPSNSPs
S343 KSEIRESSPSNSPsP
S345 EIRESSPSNSPsPQG
N346 IRESSPSNSPsPQGF
S347 RESSPSNSPsPQGFR
S349-p SSPSNSPsPQGFRKR
S360 FRKRHLFSSTENLAA
S361 RKRHLFSSTENLAAR
T362 KRHLFSSTENLAARS
S369 TENLAARSPKEPGEG
S386 MSSDRRLSDSSTKDS
S388 SDRRLSDSSTKDSMK
T390 RRLSDSSTKDSMKSM
K391 RLSDSSTKDSMKSMS
S393 SDSSTKDSMKSMSLP
S398 KDSMKSMSLPSYRPL
S401 MKSMSLPSYRPLTTA
Y402 KSMSLPSYRPLTTAD
S438 KQESKKSSLLSLVTG
S441 SKKSSLLSLVTGKKD
T444 SSLLSLVTGKKDVAK
K446 LLSLVTGKKDVAKGS
- gap
P486 EEDLVRRPEKDAVPV
A490 VRRPEKDAVPVASQW
S495 KDAVPVASQWGSSQN
S499 PVASQWGSSQNPFED
S500 VASQWGSSQNPFEDA
S518 DLEASVESKCEPKPP
- gap
- gap
- gap
S544-p VKPRLEVsPEAQPKA
S555 QPKARLPSSDSAPFA
S558 ARLPSSDSAPFAAFL
S632 LLLRAISSVTPAANA
T634 LRAISSVTPAANAGS
A639 SVTPAANAGSSASRS
T653 SPCEQLPTPERKGPQ
S663 RKGPQESSGGKARES
- gap
- gap
S678 GTGKEVGSDESEKSL
S684 GSDESEKSLIGQHEE
- gap
- gap
- gap
R742 QNASGGQRKAKKRVS
S792 SSMPSAGSPESPHTE
T798 GSPESPHTEGTGQEP
T801 ESPHTEGTGQEPVTI
- gap
S887-p PSIPEVAsDDERFDE
S1041 KQATADVSSNRVENF
T1096 NTTAPKITNSSLGTA
S1099 APKITNSSLGTATII
T1102 ITNSSLGTATIISEN
K1117 LINEALMKKYQPSDP
K1118 INEALMKKYQPSDPA
- gap
S1122 LMKKYQPSDPAFAYA
T1132 AFAYAQLTHDELIQL
K1142 ELIQLVLKQKETISK
- gap
  Rab11FIP1 iso7  
K132 KKQWYTLKSKPGKKD
K134 QWYTLKSKPGKKDKE
T157 QFMRNNMTASMFDLS
S159 MRNNMTASMFDLSMK
N187 IKGKNKDNTSDTASA
S189 GKNKDNTSDTASAIV
T191 NKDNTSDTASAIVPS
S193 DNTSDTASAIVPSTT
S198 TASAIVPSTTPSVDS
T200 SAIVPSTTPSVDSDD
S202 IVPSTTPSVDSDDES
S205 STTPSVDSDDESFSK
S209 SVDSDDESFSKDKKK
T222 KKKSKIKTLFSKPSL
S225 SKIKTLFSKPSLQKT
P227 IKTLFSKPSLQKTPL
T232 SKPSLQKTPLSQSMS
S235 SLQKTPLSQSMSVLP
S237 QKTPLSQSMSVLPTS
S239 TPLSQSMSVLPTSKP
S244 SMSVLPTSKPDKVLL
S270 EGDNEDESSSASEVM
S272 DNEDESSSASEVMSQ
T282 EVMSQKRTSSTDHTQ
S284 MSQKRTSSTDHTQPN
T285 SQKRTSSTDHTQPNQ
S296 QPNQSNFSLPKKEGL
S304 LPKKEGLSFLGGLRS
S319 KNDSLSRSNVCINGN
Y329 CINGNHVYMEQPEAK
S337 MEQPEAKSEIRESSP
S342 AKSEIRESSPSNSPS
S343 KSEIRESSPSNSPSP
S345 EIRESSPSNSPSPQG
N346 IRESSPSNSPSPQGF
S347 RESSPSNSPSPQGFR
S349 SSPSNSPSPQGFRKR
S360 FRKRHLFSSTENLAA
S361 RKRHLFSSTENLAAR
T362 KRHLFSSTENLAARS
S369 TENLAARSPKEPGEG
S386 MSSDRRLSDSSTKDS
S388 SDRRLSDSSTKDSMK
T390 RRLSDSSTKDSMKSM
K391 RLSDSSTKDSMKSMS
S393 SDSSTKDSMKSMSLP
S398 KDSMKSMSLPSYRPL
S401 MKSMSLPSYRPLTTA
Y402 KSMSLPSYRPLTTAD
S438 KQESKKSSLLSLVTG
S441 SKKSSLLSLVTGKKD
T444 SSLLSLVTGKKDVAK
K446 LLSLVTGKKDVAKGS
- gap
P486 EEDLVRRPEKDAVPV
A490 VRRPEKDAVPVASQW
S495 KDAVPVASQWGSSQN
S499 PVASQWGSSQNPFED
S500 VASQWGSSQNPFEDA
S518 DLEASVESKCEPKPP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T555 NTTAPKITNSSLGTA
S558 APKITNSSLGTATII
T561 ITNSSLGTATIISEN
K576 LINEALMKKYQPSDP
K577 INEALMKKYQPSDPA
- gap
S581 LMKKYQPSDPAFAYA
T591 AFAYAQLTHDELIQL
K601 ELIQLVLKQKETISK
- gap
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