Home

SIRT5 (human)

Overview SIRT5 NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. Belongs to the sirtuin family. Class III subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.5.1.-; Deacetylase; Mitochondrial Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space Molecular Function: zinc ion binding; NAD+ ADP-ribosyltransferase activity Biological Process: protein amino acid ADP-ribosylation; protein amino acid deacetylation; chromatin silencing Reference #:  Q9NXA8 (UniProtKB) Alt. Names/Synonyms: FLJ36950; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIR2L5; SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin type 5 Gene Symbols: SIRT5 Molecular weight: 33,881 Da Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SIRT5 2B4Y - A/B/C/D=34-302 (human) 2NYR - A/B=34-302 (human) 3RIG - A/B=34-302 (human) 3RIY - A/B=34-302 (human) 4F4U - A/B=34-302 (human) 4F56 - A/B=34-302 (human) 4G1C - A/B=36-302 (human) 4HDA - A/B=34-302 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y76-p	TFRGAGGyWRKWQAQ
0	1		S160-p	NLLEIHGsLFKTRCT
0	2		K187	ICPALSGKGAPEPGT
0	2		K203	DASIPVEKLPRCEEA

	mouse
Y76	TFRGAGGYWRKWQAQ
T160	NLLEIHGTLFKTRCT
K187	ICPALAGKGAPEPET
K203	DARIPVDKLPRCEEA

	rat
Y76	TFRGTGGYWRKWQAQ
T160	NLLEIHGTLFKTRCT
K187-u	ICPALLGkGAPEPDT
K203-u	ESRIPVHkLPRCEEA

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.