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Protein Page:
SIRT5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SIRT5 NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. Belongs to the sirtuin family. Class III subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial
Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space; nucleus; cytosol
Molecular Function: zinc ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: protein amino acid ADP-ribosylation; protein amino acid deacetylation; chromatin silencing
Reference #:  Q9NXA8 (UniProtKB)
Alt. Names/Synonyms: FLJ36950; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIR2L5; SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin type 5
Gene Symbols: SIRT5
Molecular weight: 33,881 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SIRT5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K20 SQLYCGLKPPASTRN
0 1 Y76-p TFRGAGGyWRKWQAQ
0 1 S160-p NLLEIHGsLFKTRCT
0 2 K187 ICPALSGKGAPEPGT
0 2 K203 DASIPVEKLPRCEEA
  mouse

 
K20-sc SQLCCRRkPPASPQS
Y76 TFRGAGGYWRKWQAQ
T160 NLLEIHGTLFKTRCT
K187 ICPALAGKGAPEPET
K203 DARIPVDKLPRCEEA
  rat

 
K20 SQLCCGPKPSASPQS
Y76 TFRGTGGYWRKWQAQ
T160 NLLEIHGTLFKTRCT
K187-ub ICPALLGkGAPEPDT
K203-ub ESRIPVHkLPRCEEA
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