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DSG4 (human)

Overview DSG4 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Defects in DSG4 are the cause of hypotrichosis type 6 (HYPT6). A condition characterized by the presence of less than the normal amount of hair, involving mainly the scalp, chest, arms and legs. It is characterized by abnormal hair follicles and shafts, which are thin and atrophic. Autoantibodies against DSG4 are found in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral Cellular Component: desmosome; plasma membrane; extracellular region; integral to membrane Molecular Function: calcium ion binding Biological Process: keratinocyte differentiation; BMP signaling pathway; homophilic cell adhesion; anagen Reference #:  Q86SJ6 (UniProtKB) Alt. Names/Synonyms: Cadherin family member 13; CDGF13; CDH family member 13; CDHF13; desmoglein 4; Desmoglein-4; DSG4; LAH Gene Symbols: DSG4 Molecular weight: 113,824 Da Basal Isoelectric point: 4.42  Predict pI for various phosphorylation states

Select Structure to View Below DSG4

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 607892 607903  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T120-p	SVVDREItPLFLIYC
0	1		S204-p	KIVSQEPsGAPMFIL
0	1		T544-p	DMWDVRStNATSAIL
0	1		A772	TLRDYADADINMAFL

	mouse
T120	SVVDREITPLFLIHC
A204	KIISQEPAGAPMFMV
I544	NIWDIRSINGTSAIL
T772-p	TLREYQDtGMNMAFL

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