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Protein Page:
WFS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WFS1 Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; dendrite; integral to endoplasmic reticulum membrane
Molecular Function: calmodulin binding; transcription activator binding; transporter activity; ubiquitin protein ligase binding; calcium-dependent protein binding; ATPase binding
Biological Process: ER-associated protein catabolic process; protein maturation via protein folding; protein stabilization; olfactory behavior; positive regulation of proteolysis; unfolded protein response; negative regulation of transcription factor activity; glucose homeostasis; positive regulation of protein metabolic process; neurological system process; calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; sensory perception of sound; visual perception; positive regulation of protein ubiquitination; negative regulation of programmed cell death; renal water homeostasis; negative regulation of neuron apoptosis; positive regulation of calcium ion transport; kidney development; positive regulation of growth; ER overload response
Reference #:  O76024 (UniProtKB)
Alt. Names/Synonyms: FLJ51211; WFRS; WFS; WFS1; Wolfram syndrome 1 (wolframin); Wolframin
Gene Symbols: WFS1
Molecular weight: 100,292 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WFS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T5 ___MDSNTAPLGPSC
0 1 S11 NTAPLGPSCPQPPPA
0 1 S25-p APQPQARsRLNAtAs
0 1 T30-p ARsRLNAtAsLEQER
0 11 S32-p sRLNAtAsLEQERSE
0 1 K108 KAQTEVGKHYLQLAG
0 4 S157 ADRRGITSENEREVR
1 124 S235-p RMLERLVssEsKNyI
1 21 S236-p MLERLVssEsKNyIA
0 3 S238-p ERLVssEsKNyIALD
0 1 Y241-p VssEsKNyIALDDFV
0 1 K252-ub DDFVEITkKYAkGVI
0 1 K256-ub EITkKYAkGVIPSSL
0 1 K277-ub DDDELAGksPEDLPL
0 1 S278-p DDELAGksPEDLPLR
0 1 K369-ub LKVFQDSkAWENFRT
0 2 S619 WWTKASFSVVGMVKS
0 1 S626 SVVGMVKSLTRssMV
0 1 T628 VGMVKSLTRssMVKL
0 1 S630-p MVKSLTRssMVKLIL
0 1 S631-p VKSLTRssMVKLILV
0 1 K679-ub LCGPRAWkETNMART
0 1 T778 DRYKFEITVGMPFSS
0 2 S785 TVGMPFSSGADGSRs
0 1 S792-p SGADGSRsREEDDVt
0 2 T799-p sREEDDVtkDIVLRA
0 4 K800-ub REEDDVtkDIVLRAS
0 1 K811-ub LRASSEFkSVLLSLR
0 1 K836-ub LEGRLGSkWPVFELK
  mouse

 
T5-p ___MNSGtPPPSPsG
S11-p GtPPPSPsGPPPPPA
A25 APQPQARARLNAtAs
T30-p ARARLNAtAsLEQDK
S32-p ARLNAtAsLEQDKIE
K109-ac KAQTEVGkHYLRLAN
S158-p ADRKGITsENEAEVK
S236-p RMLERLVssEsKNYI
S237-p MLERLVssEsKNYIA
S239-p ERLVssEsKNYIALD
Y242 VssEsKNYIALDDFV
K253 DDFVELTKKYAKGII
K257 ELTKKYAKGIIPTNL
K279 DEDELAGKSPEDLPL
S280 EDELAGKSPEDLPLR
K371 LKVFQDSKAWENFRT
S621-p WWTKANFsVMGMVKs
S628-p sVMGMVKsLtKSSMV
T630-p MGMVKsLtKSSMVKL
S632 MVKsLtKSSMVKLIL
S633 VKsLtKSSMVKLILV
K681 LCGPRAWKETNMART
T780-p DRYKFEItVGMPFGt
T787-p tVGMPFGtNGNRGHE
G792 FGtNGNRGHEEDDIT
T799 GHEEDDITKDIVLRA
K800 HEEDDITKDIVLRAS
K811 LRASSEFKDVLLNLR
K836 LEGRLGSKWPVFELK
  rat

 
T5 ___MSSGTPPPSPSG
S11 GTPPPSPSGPPPPPA
A25 APQPQARARLNATTS
T30 ARARLNATTSLEQDK
S32 ARLNATTSLEQDKIE
K109 KAQTEVGKHYLRLAN
S158 ADRKGITSENEAEVK
S236 RMLERLVSSESKNYI
S237 MLERLVSSESKNYIA
S239 ERLVSSESKNYIALD
Y242 VSSESKNYIALDDFV
K253 DDFVELTKKYAKGII
K257 ELTKKYAKGIIPNNL
K279 DEDELSGKSPEDLPL
S280 EDELSGKSPEDLPLR
K371 LKVFQDSKAWENFRT
S621 WWTKANFSVVGMVKS
S628 SVVGMVKSLTRSSIV
T630 VGMVKSLTRSSIVKL
S632 MVKSLTRSSIVKLIL
S633 VKSLTRSSIVKLILV
K681 LCGPRAWKETNMART
T780 DRYKFEITVGMPFGt
T787-p TVGMPFGtNGNRGHE
- under review  
T799-p GHEEDDItKDIVLRA
K800 HEEDDItKDIVLRAS
K811 LRASSEFKDVLLNLR
K836 LEGRLGSKWPVFELK
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