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Protein Page:
WFS1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
WFS1 Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; dendrite; integral to endoplasmic reticulum membrane
Molecular Function: calmodulin binding; transcription activator binding; transporter activity; ubiquitin protein ligase binding; calcium-dependent protein binding; ATPase binding
Biological Process: ER-associated protein catabolic process; protein maturation via protein folding; olfactory behavior; protein stabilization; positive regulation of proteolysis; unfolded protein response; negative regulation of transcription factor activity; glucose homeostasis; positive regulation of protein metabolic process; neurological system process; calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; sensory perception of sound; visual perception; positive regulation of protein ubiquitination; negative regulation of programmed cell death; renal water homeostasis; negative regulation of neuron apoptosis; positive regulation of calcium ion transport; kidney development; positive regulation of growth; ER overload response
Reference #:  O76024 (UniProtKB)
Alt. Names/Synonyms: FLJ51211; WFRS; WFS; WFS1; Wolfram syndrome 1 (wolframin); Wolframin
Gene Symbols: WFS1
Molecular weight: 100,292 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WFS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T5 ___MDSNTAPLGPSC
0 1 S11 NTAPLGPSCPQPPPA
0 9 S32-p SRLNATAsLEQERSE
0 3 S157 ADRRGITSENEREVR
1 116 S235-p RMLERLVssEsKNYI
1 19 S236-p MLERLVssEsKNYIA
0 3 S238-p ERLVssEsKNYIALD
0 1 K252-u DDFVEITkKYAkGVI
0 1 K256-u EITkKYAkGVIPSSL
0 1 K277-u DDDELAGkSPEDLPL
0 2 S619 WWTKASFSVVGMVKS
0 1 S626 SVVGMVKSLTRssMV
0 1 T628 VGMVKSLTRssMVKL
0 1 S630-p MVKSLTRssMVKLIL
0 1 S631-p VKSLTRssMVKLILV
0 1 K679-u LCGPRAWkETNMART
0 1 T778 DRYKFEITVGMPFSS
0 2 S785 TVGMPFSSGADGSRS
0 1 T799 SREEDDVTkDIVLRA
0 4 K800-u REEDDVTkDIVLRAS
0 1 K811-u LRASSEFkSVLLSLR
0 1 K836-u LEGRLGSkWPVFELK
  mouse

 
T5-p ___MNSGtPPPSPsG
S11-p GtPPPSPsGPPPPPA
S32-p ARLNATAsLEQDKIE
S158-p ADRKGITsENEAEVK
S236-p RMLERLVssEsKNYI
S237-p MLERLVssEsKNYIA
S239-p ERLVssEsKNYIALD
K253 DDFVELTKKYAKGII
K257 ELTKKYAKGIIPTNL
K279 DEDELAGKSPEDLPL
S621-p WWTKANFsVMGMVKs
S628-p sVMGMVKsLtKSSMV
T630-p MGMVKsLtKSSMVKL
S632 MVKsLtKSSMVKLIL
S633 VKsLtKSSMVKLILV
K681 LCGPRAWKETNMART
T780-p DRYKFEItVGMPFGt
T787-p tVGMPFGtNGNRGHE
T799 GHEEDDITKDIVLRA
K800 HEEDDITKDIVLRAS
K811 LRASSEFKDVLLNLR
K836 LEGRLGSKWPVFELK
  rat

 
T5 ___MSSGTPPPSPSG
S11 GTPPPSPSGPPPPPA
S32 ARLNATTSLEQDKIE
S158 ADRKGITSENEAEVK
S236 RMLERLVSSESKNYI
S237 MLERLVSSESKNYIA
S239 ERLVSSESKNYIALD
K253 DDFVELTKKYAKGII
K257 ELTKKYAKGIIPNNL
K279 DEDELSGKSPEDLPL
S621 WWTKANFSVVGMVKS
S628 SVVGMVKSLTRSSIV
T630 VGMVKSLTRSSIVKL
S632 MVKSLTRSSIVKLIL
S633 VKSLTRSSIVKLILV
K681 LCGPRAWKETNMART
T780 DRYKFEITVGMPFGt
T787-p TVGMPFGtNGNRGHE
T799-p GHEEDDItKDIVLRA
K800 HEEDDItKDIVLRAS
K811 LRASSEFKDVLLNLR
K836 LEGRLGSKWPVFELK
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