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Protein Page:
NFkB-p105 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFkB-p105 a transcription factor of the nuclear factor-kappaB ( NFkB) group. Undergoes cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of NFkB. NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein binding; protein homodimerization activity; heat shock protein binding; double-stranded DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of cholesterol transport; positive regulation of transcription, DNA-dependent; negative regulation of cellular protein metabolic process; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; membrane protein intracellular domain proteolysis; MyD88-independent toll-like receptor signaling pathway; negative regulation of interleukin-12 biosynthetic process; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to copper ion; negative regulation of inflammatory response; negative regulation of cytokine production; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; toll-like receptor 9 signaling pathway; negative regulation of apoptosis
Reference #:  P19838 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C01211; DNA binding factor KBF1; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFKB1; nuclear factor kappa-B DNA binding subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50
Gene Symbols: NFKB1
Molecular weight: 105,356 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFkB-p105

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S337‑p
transcription, inhibited: S328‑p
activity, induced: S893‑p, S907‑p
molecular association, regulation: S20‑p, S328‑p
protein degradation: S923‑p, S927‑p, S932‑p
protein processing: S893‑p, S907‑p, S927‑p
protein stabilization: S903‑p, S907‑p
ubiquitination: S927‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S20-p QMFHLDPsLTHTIFN
0 2 Y59-p QRGFRFRyVCEGPSH
0 1 S65 RyVCEGPSHGGLPGA
0 1 S73 HGGLPGASSEKNKKS
0 1 S74 GGLPGASSEKNKKSY
0 1 Y165-p TEACIRGyNPGLLVH
0 1 S223-p FTAFLPDsTGSFtRR
0 1 T228-p PDsTGSFtRRLEPVV
0 48 Y240-p PVVSDAIyDsKAPNA
0 1 S242-p VSDAIyDsKAPNASN
0 1 T324-p KYKDINItKPAsVFV
2 0 S328-p INItKPAsVFVQLRR
3 0 S337-p FVQLRRKsDLETSEP
0 1 S371 QKLMPNFSDSFGGGS
0 3 Y409-p PGYSFPHyGFPtYGG
0 1 T413-p FPHyGFPtYGGITFH
0 1 S426 FHPGTTKSNAGMkHG
0 1 K431 TKSNAGMKHGTMDTE
1 0 K431-ac TKSNAGMkHGTMDTE
0 2 T434 NAGMkHGTMDTESkk
0 1 T437 MkHGTMDTESkkDPE
1 1 K440-ac GTMDTESkkDPEGCD
1 0 K440-ub GTMDTESkkDPEGCD
1 0 K441-ac TMDTESkkDPEGCDK
1 0 K441-ub TMDTESkkDPEGCDK
0 8 S449-p DPEGCDKsDDKNTVN
0 1 - gap
0 2 Y485-p NGEVTLTyATGTKEE
0 1 K504-ub QDNLFLEkAMQLAKR
0 1 Y582-p INMRNDLyQtPLHLA
0 1 T584-p MRNDLyQtPLHLAVI
0 2 K636 KVLSILLKHKKAALL
0 1 H695 ALHLAVEHDNISLAG
0 1 S699 AVEHDNISLAGCLLL
0 2 S759 PLYDLDDSWENAGED
0 1 K821-ub DVKLQLYkLLEIPDP
0 3 S851-p LNNAFRLsPAPskTL
0 1 S855-p FRLsPAPskTLMDNY
0 1 K856-ub RLsPAPskTLMDNYE
0 1 - gap
0 1 - gap
0 3 S892-p IEVIQAAssPVKTTs
2 12 S893-p EVIQAAssPVKTTsQ
0 1 T897 AAssPVKTTsQAHsL
0 1 T898 AssPVKTTsQAHsLP
0 4 S899-p ssPVKTTsQAHsLPL
1 22 S903-p KTTsQAHsLPLsPAs
2 129 S907-p QAHsLPLsPAstRQQ
0 4 S910-p sLPLsPAstRQQIDE
0 1 T911-p LPLsPAstRQQIDEL
2 2 S923-p DELRDSDsVCDsGVE
6 2 S927-p DSDsVCDsGVETsFR
4 0 S932-p CDsGVETsFRKLsFt
0 24 S937-p ETsFRKLsFtEsLTS
0 4 T939-p sFRKLsFtEsLTSGA
0 2 S941-p RKLsFtEsLTSGASL
0 1 T943 LsFtEsLTSGASLLT
0 1 A946 tEsLTSGASLLTLNK
4806 : Phospho-NF-KappaB p105 (Ser933) (18E6) Rabbit mAb
4808 : Phospho-NF-KappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)
4884 : Phospho-NF-kappaB p105 (Ser933) Antibody
  mouse

 
A18 QMFHLNTALTHSIFN
Y57 QRGFRFRYVCEGPsH
S63-p RYVCEGPsHGGLPGA
S71-p HGGLPGAssEKNKKS
S72-p GGLPGAssEKNKKSY
Y163 TEACIRGYNPGLLVH
S221 FTAFLPDSTGSFTRR
T226 PDSTGSFTRRLEPVV
Y238-p PVVSDAIyDSKAPNA
S240 VSDAIyDSKAPNASN
T322 KYKDVNITKPASVFV
S326 VNITKPASVFVQLRR
S335 FVQLRRKSDLETSEP
S369-p QKLMPNFsDSFGGGS
Y407 PGYGYSNYGFPPYGG
P411 YSNYGFPPYGGITFH
S424-p FHPGVTKsNAGVtHG
T429-p TKsNAGVtHGtINtK
T429 TKsNAGVTHGtINtK
T432-p NAGVtHGtINtKFKN
T435-p VtHGtINtKFKNGPK
K438 GtINtKFKNGPKDCA
K438 GtINtKFKNGPKDCA
N439 tINtKFKNGPKDCAK
N439 tINtKFKNGPKDCAK
S447-p GPKDCAKsDDEESLT
T472-p PSLPMACtKTEPIAL
S481 TEPIALASTMEDKEQ
K500 QDNLFLEKALQLARR
Y578 INMRNDLYQTPLHLA
T580 MRNDLYQTPLHLAVI
K632-ac RILSILLkSRKAAPL
Y691-p ALHLAVEyDNIsLAG
S695-p AVEyDNIsLAGCLLL
S755-p PLYDLDDsWEKAGED
K817 DTRLQLCKLLEIPDP
S847 LNNAFRLSPAPSKTL
S851 FRLSPAPSKTLMDNY
K852 RLSPAPSKTLMDNYE
T893-p AAFRTPAttAssPVt
T894-p AFRTPAttAssPVtt
S896-p RTPAttAssPVttAQ
S897-p TPAttAssPVttAQV
T900-p ttAssPVttAQVHCL
T901-p tAssPVttAQVHCLP
A902 AssPVttAQVHCLPL
C906 VttAQVHCLPLSSSS
S910 QVHCLPLSSSSTRQH
S913 CLPLSSSSTRQHIDE
T914 LPLSSSSTRQHIDEL
S926 DELRDSDSVCDSGVE
S930 DSDSVCDSGVETsFR
S935-p CDSGVETsFRKLsFt
S940-p ETsFRKLsFtEsLtG
T942-p sFRKLsFtEsLtGDs
S944-p RKLsFtEsLtGDsPL
T946-p LsFtEsLtGDsPLLS
S949-p tEsLtGDsPLLSLNK
4806 : Phospho-NF-KappaB p105 (Ser933) (18E6) Rabbit mAb
4808 : Phospho-NF-KappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)
4884 : Phospho-NF-kappaB p105 (Ser933) Antibody
  rat

 
A18 QMFHLNTALTHSIFN
Y57 QRGFRFRYVCEGPSH
S63 RYVCEGPSHGGLPGA
S71 HGGLPGASSEKNKKS
S72 GGLPGASSEKNKKSY
Y163 TEACIRGYNPGLLVH
S221 FTAFLPDSTGSFTRR
T226 PDSTGSFTRRLEPVV
Y238 PVVSDAIYDSKAPNA
S240 VSDAIYDSKAPNASN
T322 KYKDVNITKPASVFV
S326 VNITKPASVFVQLRR
S335-p FVQLRRKsDLETSEP
S369 QKLMPNFSDSFGGGS
Y408 PGYGFPHYGFPAYGG
A412 FPHYGFPAYGGIAFH
S425 FHPGATKSNTGITHG
T430 TKSNTGITHGTINTK
T430 TKSNTGITHGTINTK
T433 NTGITHGTINTKFKN
T436 ITHGTINTKFKNEPR
K439 GTINTKFKNEPRDCA
K439 GTINTKFKNEPRDCA
N440 TINTKFKNEPRDCAK
N440 TINTKFKNEPRDCAK
S448 EPRDCAKSDDREILN
T473 PSLFMASTKTEAIAP
S482 TEAIAPASTMEDKEE
K501 QDNLFLEKALQLAKR
Y579 INMRNDLYQTPLHLA
T581 MRNDLYQTPLHLAVI
K633 KILGVLLKNSKAALL
Y692 ALHLAVEYDNISLAG
S696 AVEYDNISLAGCLLL
S756-p PLYDLDDsWEKAGED
K818 DTRLQLCKLLEIPDP
S848 LNNAFRLSPAPSKTL
S852 FRLSPAPSKTLMDNY
K853 RLSPAPSKTLMDNYE
T894 AAFRTPETTASSPVT
T895 AFRTPETTASSPVTT
S897 RTPETTASSPVTTAQ
S898 TPETTASSPVTTAQA
T901 TTASSPVTTAQAHLL
T902 TASSPVTTAQAHLLP
A903 ASSPVTTAQAHLLPL
L907 VTTAQAHLLPLSSSS
S911 QAHLLPLSSSSTRQH
S914 LLPLSSSSTRQHIDE
T915 LPLSSSSTRQHIDEL
S927 DELRDNDSVCDSGVE
S931 DNDSVCDSGVETSFR
S936 CDSGVETSFRKLSFS
S941 ETSFRKLSFSESLTG
S943 SFRKLSFSESLTGDG
S945 RKLSFSESLTGDGPL
T947 LSFSESLTGDGPLLS
G950 SESLTGDGPLLSLNK
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