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NFAT1 (human)

Overview NFAT1 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. It is present in a phosphorylated the cytosol of unstimulated T cells. After T-cell activation, it is dephosphorylated by calcineurin and translocates to the nucleus as a part of a transcription complex. Two splice variant isoforms have been identified. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: cytoplasm; plasma membrane; nucleolus; cytosol; ribonucleoprotein complex; nucleus; actin cytoskeleton Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity Biological Process: response to drug; B cell receptor signaling pathway; cell migration; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; cytokine production; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus Reference #:  Q13469 (UniProtKB) Alt. Names/Synonyms: NF-ATc2; NF-ATp; NFAC2; NFAT pre-existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFATC2; NFATP; Nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1 Gene Symbols: NFATC2 Molecular weight: 100,146 Da Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NFAT1 1A02 - N=396-678 (human) 1OWR - M/N/P/Q=396-678 (human) 1P7H - L/M/N/O=396-678 (human) 1PZU - B/D/H/I/L/M=396-678 (human) 1S9K - C=399-678 (human) 2AS5 - M/N=392-678 (human) 2O93 - L/M/O=392-678 (human) 3QRF - M/N=396-678 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	16		Y36-p	DFSILFDyEyLNPNE
0	6		Y38-p	SILFDyEyLNPNEEE
0	3		S53-p	PNAHKVAsPPSGPAY
0	1		P54	NAHKVAsPPSGPAYP
0	1		S56	HKVAsPPSGPAYPDD
0	1		S73-p	DYGLKPYsPLASLSG
0	2		S99-p	VGPQKFLsAAKPAGA
0	2		S107-p	AAKPAGAsGLsPRIE
1	1		S110-p	PAGAsGLsPRIEItP
1	1		T116-p	LsPRIEItPSHELIQ
0	6		L136	RMRDAGLLVEQPPLA
0	5		S148-p	PLAGVAAsPRFTLPV
2	1		S168	YREPLCLSPASSGSS
0	1		S171	PLCLSPASSGSSASF
0	1		S172	LCLSPASSGSSASFI
0	1		S174	LSPASSGSSASFISD
0	1		S175	SPASSGSSASFISDT
0	1		S177	ASSGSSASFISDTFS
0	1		S180	GSSASFISDTFSPYT
0	1		Y212-p	FQNIPAHysPRTsPI
1	5		S213-p	QNIPAHysPRTsPIM
0	4		T216	PAHysPRTsPIMsPR
2	8		S217-p	AHysPRTsPIMsPRT
2	12		S221-p	PRTsPIMsPRTsLAE
0	1		S225-p	PIMsPRTsLAEDSCL
0	8		S236-p	DSCLGRHsPVPRPAs
0	8		S243-p	sPVPRPAsRsSsPGA
0	2		S245-p	VPRPAsRsSsPGAKR
0	4		S247-p	RPAsRsSsPGAKRRH
0	2		S255-p	PGAKRRHsCAEALVA
0	3		S268-p	VALPPGAsPQRSRSP
0	1		S274	AsPQRSRSPSPQPSS
0	1		S276	PQRSRSPSPQPSSHV
0	1		S280	RSPSPQPSSHVAPQD
0	2		T325	IPPKMWKTsPDPsPV
0	6		S326-p	PPKMWKTsPDPsPVs
1	4		S330-p	WKTsPDPsPVsAAPs
0	1		S333-p	sPDPsPVsAAPsKAG
0	2		S337-p	sPVsAAPsKAGLPRH
0	5		Y346-p	AGLPRHIyPAVEFLG
0	11		S363-p	EQGERRNsAPESILL
0	1		T374-p	SILLVPPtWPKPLVP
0	1		T483-p	VHRITGKtVtTTSYE
0	1		T485-p	RITGKtVtTTSYEKI
0	1		T585-p	PMVERQDtDSCLVYG
0	1		T599-p	GGQQMILtGQNFTsE
0	1		S605-p	LtGQNFTsESKVVFT
0	1		T615	KVVFTEKTTDGQQIW
0	1		T616	VVFTEKTTDGQQIWE
0	1		T652-p	YRNKHIRtPVKVNFY
1	0		K682	YHPVPAIKTEPTDEY
0	1		S736-p	QQFRTGLsSPDARYQ
0	20		Y752-p	QNPAAVLyQRsKsLs
0	3		S755-p	AAVLyQRsKsLsPsL
0	5		S757-p	VLyQRsKsLsPsLLG
0	7		S759-p	yQRsKsLsPsLLGYQ
0	1		S761-p	RsKsLsPsLLGYQQP
0	1		S776-p	ALMAAPLsLADAHRS
0	6		S856-p	VSQGQRLsPGsyPTV
0	1		S859-p	GQRLsPGsyPTVIQQ
0	2		Y860-p	QRLsPGsyPTVIQQQ
0	1		S882-p	AKNGPPVsDQKEVLP
0	1		T893-p	EVLPAGVtIKQEQNL
1	0		K895	LPAGVtIKQEQNLDQ
0	1		Y904-p	EQNLDQTyLDDVNEI

	mouse ► Hide Isoforms
-	gap
Y36	DFSILFDYDYLNPIE
Y38	SILFDYDYLNPIEEE
S53-p	PIAHKAIssPsGLAY
S54-p	IAHKAIssPsGLAYP
S56-p	HKAIssPsGLAYPDD
N73	DYGLKPCNPLASLSG
S99-p	IGFQNFLsPVKPAGA
S107-p	PVKPAGAsGPsPRIE
S110-p	PAGAsGPsPRIEItP
T116-p	PsPRIEItPSHELMQ
S136-p	RGRDAGLsPEQPALA
S150-p	ALAGVAAsPRFTLPV
S170-p	YREPLCLsPAssGss
S173-p	PLCLsPAssGssAsF
S174-p	LCLsPAssGssAsFI
S176-p	LsPAssGssAsFIsD
S177-p	sPAssGssAsFIsDT
S179-p	AssGssAsFIsDTFS
S182-p	GssAsFIsDTFSPYT
Y214	FQNIPAHYsPRtsPI
S215-p	QNIPAHYsPRtsPIM
T218-p	PAHYsPRtsPIMsPR
S219-p	AHYsPRtsPIMsPRT
S223-p	PRtsPIMsPRTSLAE
S227	PIMsPRTSLAEDSCL
S238-p	DSCLGRHsPVPRPAs
S245-p	sPVPRPAsRSSSPGA
S247	VPRPAsRSSSPGAKR
S249	RPAsRSSSPGAKRRH
S257-p	PGAKRRHsCAEALVA
S270-p	VAPLPAAsPQRSRsP
S276-p	AsPQRSRsPsPQPsP
S278-p	PQRSRsPsPQPsPHV
S282-p	RsPsPQPsPHVALQD
T327-p	IPSKIWKtsPDPtPV
S328-p	PSKIWKtsPDPtPVS
T332-p	WKtsPDPtPVSTAPS
S335	sPDPtPVSTAPSKAG
S339	tPVSTAPSKAGLARH
Y348-p	AGLARHIyPTVEFLG
S365-p	EQEERRNsAPESILL
T376	SILLVPPTWPKQLVP
T485	VHRITGKTVTTTSYE
T487	RITGKTVTTTSYEKI
M587	PMVERQDMDSCLVYG
T601	GGQQMILTGQNFTAE
A607	LTGQNFTAESKVVFM
T617-p	KVVFMEKttDGQQIW
T618-p	VVFMEKttDGQQIWE
V654	YRNKHIRVPVKVNFY
K684-s	YHPVPAIkTEPSDEY
S738	QQFRSGLSSPDARYQ
Y754	QSPAAALYQRsKsLs
S757-p	AAALYQRsKsLsPGL
S759-p	ALYQRsKsLsPGLLG
S761-p	YQRsKsLsPGLLGYQ
G763	RsKsLsPGLLGYQQP
G778	SLLAAPLGLADAHRS
S860-p	INQGQRLsPGAYPTV
A863	GQRLsPGAYPTVIQQ
Y864	QRLsPGAYPTVIQQQ
S884	RAAKNGPSDQKEALP
T895	EALPTGVTVkQEQNL
K897-s	LPTGVTVkQEQNLDQ
Y906	EQNLDQTYLDDVNEI

	NFAT1 iso2
S20-p	QPLRTMGsADREEPI
-	gap
-	gap
S33	PIAHKAISSPSGLAY
S34	IAHKAISSPSGLAYP
S36	HKAISSPSGLAYPDD
N53	DYGLKPCNPLASLSG
S79	IGFQNFLSPVKPAGA
S87	PVKPAGASGPSPRIE
S90	PAGASGPSPRIEITP
T96	PSPRIEITPSHELMQ
S116	RGRDAGLSPEQPALA
S130	ALAGVAASPRFTLPV
S150	YREPLCLSPASSGSS
S153	PLCLSPASSGSSASF
S154	LCLSPASSGSSASFI
S156	LSPASSGSSASFISD
S157	SPASSGSSASFISDT
S159	ASSGSSASFISDTFS
S162	GSSASFISDTFSPYT
Y194	FQNIPAHYSPRTSPI
S195	QNIPAHYSPRTSPIM
T198	PAHYSPRTSPIMSPR
S199	AHYSPRTSPIMSPRT
S203	PRTSPIMSPRTSLAE
S207	PIMSPRTSLAEDSCL
S218	DSCLGRHSPVPRPAS
S225	SPVPRPASRSSSPGA
S227	VPRPASRSSSPGAKR
S229	RPASRSSSPGAKRRH
S237	PGAKRRHSCAEALVA
S250	VAPLPAASPQRSRSP
S256	ASPQRSRSPSPQPSP
S258	PQRSRSPSPQPSPHV
S262	RSPSPQPSPHVALQD
T307	IPSKIWKTSPDPTPV
S308	PSKIWKTSPDPTPVS
T312	WKTSPDPTPVSTAPS
S315	SPDPTPVSTAPSKAG
S319	TPVSTAPSKAGLARH
Y328-p	AGLARHIyPTVEFLG
S345	EQEERRNSAPESILL
T356	SILLVPPTWPKQLVP
T465	VHRITGKTVTTTSYE
T467	RITGKTVTTTSYEKI
M567	PMVERQDMDSCLVYG
T581	GGQQMILTGQNFTAE
A587	LTGQNFTAESKVVFM
T597	KVVFMEKTTDGQQIW
T598	VVFMEKTTDGQQIWE
V634	YRNKHIRVPVKVNFY
K664	YHPVPAIKTEPSDEY
S718	QQFRSGLSSPDARYQ
Y734	QSPAAALYQRSKSLS
S737	AAALYQRSKSLSPGL
S739	ALYQRSKSLSPGLLG
S741	YQRSKSLSPGLLGYQ
G743	RSKSLSPGLLGYQQP
G758	SLLAAPLGLADAHRS
S840	INQGQRLSPGAYPTV
A843	GQRLSPGAYPTVIQQ
Y844	QRLSPGAYPTVIQQQ
S864	RAAKNGPSDQKEALP
T875	EALPTGVTVKQEQNL
K877	LPTGVTVKQEQNLDQ
Y886	EQNLDQTYLDDELID

	chicken
-	gap
Y43	DFSILFDYDYLKPIE
Y45	SILFDYDYLKPIEEE
S60	PTPHKTNSPPSGVAY
P61	TPHKTNSPPSGVAYA
S63	HKTNSPPSGVAYAHD
P80	DCGLKPCPLPFPSLS
H106	SIGTAPTHPASAAGA
S114	PASAAGASAPSPRIE
S117	AAGASAPSPRIEITS
T123	PSPRIEITSYPELIN
-	gap
S155	QSNSATTSPRVTLPV
S175-p	YREPLCLsPASSGSS
S178	PLCLsPASSGSSASF
S179	LCLsPASSGSSASFI
S181	LsPASSGSSASFISE
S182	sPASSGSSASFISET
S184	ASSGSSASFISETNL
S187	GSSASFISETNLSPC
Y220	FQNIHTHYSPRTSPI
S221	QNIHTHYSPRTSPIM
T224	HTHYSPRTSPIMSPR
S225	THYSPRTSPIMSPRT
S229	PRTSPIMSPRTSITE
S233	PIMSPRTSITEETCL
S244	ETCLGQHSPSPRPNS
S251	SPSPRPNSRSSSPGA
S253	SPRPNSRSSSPGAKR
S255	RPNSRSSSPGAKRRY
S263	PGAKRRYSCTQQPST
S271	CTQQPSTSPRQSRTP
T277	TSPRQSRTPSPQSSP
S279	PRQSRTPSPQSSPRI
S283	RTPSPQSSPRIPLRE
T328	VPTKIWKTSPDPSSM
S329	PTKIWKTSPDPSSMP
S333	WKTSPDPSSMPSHKN
S334	KTSPDPSSMPSHKNS
H338	DPSSMPSHKNSIPCH
F347	NSIPCHVFQTVDFHG
S364	EQEDRRNSAPESILL
S375	SILLVPPSWTKQLMP
T483	VHRITGKTVTTTSYE
T485	RITGKTVTTTSYEKI
I585	PMVERQDIDSCLVYG
T599	GGQQMILTGQNFTAE
A605	LTGQNFTAESKVVFT
T615	KVVFTEKTSDGQQIW
S616	VVFTEKTSDGQQIWE
T652	YRNKHIRTPVKVNFY
K682	YHPVPSIKTEPIDDY
S738	QQLRSGLSSPDSRYH
Y754	QNPAAVVYQRSKSLS
S757	AAVVYQRSKSLSPSQ
S759	VVYQRSKSLSPSQLG
S761	YQRSKSLSPSQLGYQ
S763	RSKSLSPSQLGYQQS
A778	SLMATPVAISDAHRS
S858	VSQAQRLSPSSYPTV
S861	AQRLSPSSYPTVIQQ
Y862	QRLSPSSYPTVIQQQ
S884	AKNGPPVSDQKEVLP
T895	EVLPAGVTIKQEQNL
K897	LPAGVTIKQEQNLDQ
Y906	EQNLDQAYLDDAHWG

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