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Protein Page:
cIAP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
cIAP2 Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and USP19. Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination. Belongs to the IAP family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Ubiquitin conjugating system; Ligase; EC 6.3.2.-; Ubiquitin ligase
Cellular Component: protein complex; cytoplasm; nucleolus; cytosol; nucleus; lipid raft
Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: regulation of toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein heterooligomerization; apoptosis; MyD88-independent toll-like receptor signaling pathway; protein ubiquitination; toll-like receptor 3 signaling pathway; regulation of innate immune response; regulation of apoptosis; cell surface receptor linked signal transduction; positive regulation of protein ubiquitination; regulation of inflammatory response; toll-like receptor signaling pathway; negative regulation of phosphorylation; innate immune response; spermatogenesis; toll-like receptor 4 signaling pathway; negative regulation of apoptosis
Reference #:  Q13489 (UniProtKB)
Alt. Names/Synonyms: AIP1; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; BIRC3; C-IAP2; CIAP2; HAIP1; hIAP-1; hIAP1; IAP homolog C; IAP-1; IAP1; Inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RING finger protein 49; RNF49; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
Gene Symbols: BIRC3
Molecular weight: 68,372 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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cIAP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MNIVENsIFLsNLM
0 1 S11-p VENsIFLsNLMKSAN
0 1 N12 ENsIFLsNLMKSANT
0 1 S141-p FRGSYSNsPSNPVNS
0 1 N170 HCAMNNENARLLTFQ
0 1 K191 LSPTDLAKAGFYYIG
0 2 K211-ub ACFACGGkLSNWEPk
0 1 K218-ub kLSNWEPkDNAMSEH
0 1 K231-ub EHLRHFPkCPFIENQ
0 1 Y245 QLQDTSRYTVsNLSM
0 1 T246 LQDTSRYTVsNLSMQ
0 1 S248-p DTSRYTVsNLSMQtH
0 1 S251 RYTVsNLSMQtHAAR
0 1 T254-p VsNLSMQtHAARFkT
0 1 K260-ub QtHAARFkTFFNWPS
0 1 S278-p VNPEQLAsAGFYYVG
0 1 T398-p SRSLVKQtVQRKILA
0 1 K587-ub DCAPSLRkCPICRST
0 1 K596-ub PICRSTIkGTVRTFL
  mouse

 
S5 ___MVQDSAFLAkLM
A9 VQDSAFLAkLMKSAD
K10-ac QDSAFLAkLMKSADT
F139 FSGSYSSFPSDPVNF
K168-ub HFAMNTEkARLLTYE
K189-ub LSPAKLAkAGFYYIG
K209 ACFACDGKLSNWERK
K216 KLSNWERKDDAMSEH
S229 EHQRHFPSCPFLKDL
Y243-p LGQSASRytVSNLsM
T244-p GQSASRytVSNLsMQ
S246 SASRytVSNLsMQTH
S249-p RytVSNLsMQTHAAR
T252 VSNLsMQTHAARIRT
R258 QTHAARIRTFSNWPS
S276 VHSQELASAGFYYTG
T395 SRSLVRQTVQWQILA
K583 DCAPSLRKCPICRGT
K592 PICRGTIKGTVRTFL
  rat

 
S7 _MNMVQGSAFLAKLM
A11 VQGSAFLAKLMKSAD
K12 QGSAFLAKLMKSADT
F141 FSGSYSSFPSDPVNF
K170 HFAMNTEKARLLTYQ
K191 LSPAELAKAGFYYTG
K211 ACFACGGKLSNWDRK
K218 KLSNWDRKDDPLSEH
S231 EHRRHFPSCPFLKDV
Y245 VGQFTSQYTVSNLSM
T246 GQFTSQYTVSNLSMQ
S248 FTSQYTVSNLSMQTH
S251 QYTVSNLSMQTHAAR
T254 VSNLSMQTHAARVRT
R260 QTHAARVRTFSTWPS
S278 VHPQELASAGFYYTG
T397 SRSLVRQTVQRQILA
K585 ECAPSLRKCPICRGT
K594 PICRGTIKGTVRTFL
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