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POLE (human)

Overview POLE Participates in DNA repair and in chromosomal DNA replication. Belongs to the DNA polymerase type-B family. Note: This description may include information from UniProtKB. Protein type: DNA repair; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 2.7.7.7; Transferase; DNA replication Cellular Component: nucleoplasm; epsilon DNA polymerase complex; nucleus Molecular Function: DNA binding; zinc ion binding; 4 iron, 4 sulfur cluster binding; nucleotide binding; DNA-directed DNA polymerase activity; chromatin binding Biological Process: DNA replication initiation; in utero embryonic development; M/G1 transition of mitotic cell cycle; DNA repair; base-excision repair, gap-filling; telomere maintenance via semi-conservative replication; DNA synthesis during DNA repair; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; DNA replication; S phase of mitotic cell cycle; telomere maintenance; G1/S transition of mitotic cell cycle Reference #:  Q07864 (UniProtKB) Alt. Names/Synonyms: DKFZp434F222; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A; DPOE1; FLJ21434; POLE; POLE1; polymerase (DNA directed), epsilon Gene Symbols: POLE Molecular weight: 261,518 Da Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states

Select Structure to View Below POLE

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y84-p	RLGSAVDyyFIQDDG
0	1		Y85-p	LGSAVDyyFIQDDGS
0	1		Y100-p	RFKVALPyKPYFYIA
0	1		S156-p	KRNYIRLsFHTVEDL
0	1		G199	SSVLQRGGVItDEEE
0	7		T202-p	LQRGGVItDEEETSk
0	1		S208	ItDEEETSkKIADQL
0	1		K209-u	tDEEETSkKIADQLD
0	3		S382-p	RAAVHGLsMQQEIGF
0	1		K1050-u	LEDYGEQkSTSISTA
0	1		S1184-p	VYKQKKIsELFTLEG
0	1		Y1490-p	SIRHIYLyHHAQAHK
0	1		S1797-p	NTFRILKsMVVGWVK
0	27		S1940-p	IHCGLQDsQKAGGAE
0	4		T2023-p	RRSAPGStPVRRRGA
0	1		K2110-u	EFIKYVCkVLSLDTN
0	2		K2124-u	NITNQVNkLNRDLLR
0	1		K2210	LVEVLQKKLMAFtLQ
0	1		T2215-p	QKKLMAFtLQDLVCL
0	1		-	gap
0	1		-	gap

	POLE iso2
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
K25	EFIKYVCKVLSLDTN
K39	NITNQVNKLNRDLLR
K125	LVEVLQKKLMAFTLQ
T130	QKKLMAFTLQDLkEA
K135-a	AFTLQDLkEADTPKC
K149-a	CEEKERRkRELHSSA

	mouse
Y84	RLVSAVDYYFIQDDG
Y85	LVSAVDYYFIQDDGS
Y100	RFKVALPYMPYFYIA
S156	KRSYIKLSFHTVEDL
S199	SSILQGGSVITDEDE
T202	LQGGSVITDEDETSK
S208	ITDEDETSKKIADQL
K209	TDEDETSKKIADQLD
S382	RAAIHGLSMYQEIGF
K1050	LEDYGEQKSTSISTA
S1184	IYKQKKISELFVLEG
Y1489	SIRHIYLYHHTQGHK
S1796	STFRILKSMVVGWVK
E1939	IHCGQVKEQDSQARE
T2020	RHSAPGSTPVKRKGA
K2107	EFIKYVCKVLSLDTN
K2121	NITNQVNKLNRDLLR
K2207-a	LVEALQRkLMAFTLQ
T2212	QRkLMAFTLQDLVCL
-	gap
-	gap

	rat
Y84	RLVSAVDYYFIQDDG
Y85	LVSAVDYYFIQDDGS
Y100	RFKVALPYKPYFYIA
S156	KRSYIKLSFHTVEDL
S199-p	SSILQGGsLItDEEE
T202-p	LQGGsLItDEEETsK
S208-p	ItDEEETsKKIADQL
K209	tDEEETsKKIADQLD
S382	RAAIHGLSMYQEIGF
K1053	LEDYGEQKSTSISTA
S1187	IYKQKKISELFVLEG
Y1492	SIRHIYLYHHTQGHK
S1799	STFRILKSMVVGWVK
E1942	IHCGQVREQDSQTRE
T2023	RHSAPGSTPVKRKGA
K2110	EFIKYVCKVLSLDTN
K2124	NITNQVNKLNRDLLR
K2210	LVEALQRKLMAFTLQ
T2215	QRKLMAFTLQDLVCL
-	gap
-	gap

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