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Protein Page:
MOR-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MOR-1 a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q24-q25
Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; voltage-gated calcium channel activity; protein binding; G-protein alpha-subunit binding; beta-endorphin receptor activity
Biological Process: positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; negative regulation of nitric oxide biosynthetic process; cellular response to stress; negative regulation of adenylate cyclase activity; locomotory behavior; behavioral response to ethanol; sensory perception of pain; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; sensory perception; reduction of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase inhibiting pathway; dopamine receptor, adenylate cyclase activating pathway
Reference #:  P35372 (UniProtKB)
Alt. Names/Synonyms: hMOP; KIAA0403; LMOR; M-OR-1; MOP; MOR; MOR-1; MOR1; Mu opiate receptor; Mu opioid receptor; Mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1
Gene Symbols: OPRM1
Molecular weight: 44,779 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Select Structure to View Below

MOR-1

Protein Structure Not Found.


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Sites Implicated In
signaling pathway regulation: S377‑p
receptor desensitization, altered: S268‑p
receptor desensitization, inhibited: T396‑p
receptor internalization, altered: S365‑p, T372‑p, S377‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S57 TDLGGRDSLCPPTGS
1 0 T99 MYVIVRYTKMKTATN
1 0 T103 VRYTKMKTATNIYIF
1 0 T105 YTKMKTATNIYIFNL
2 0 Y108 MKTATNIYIFNLALA
3 0 Y168-p CTMSVDRyIAVCHPV
3 0 T182 VKALDFRTPRNAKII
2 2 S263-p LMILRLKsVRMLsGs
3 2 S268-p LKsVRMLsGsKEKDR
0 2 S270-p sVRMLsGsKEKDRNL
2 0 Y338-p SCLNPVLyAFLDENF
1 0 S357 REFCIPTSSNIEQQN
0 1 S358 EFCIPTSSNIEQQNs
1 1 N359 FCIPTSSNIEQQNsT
8 4 S365-p SNIEQQNsTRIRQNt
13 2 T372-p sTRIRQNtRDHPstA
17 2 S377-p QNtRDHPstANTVDR
4 1 T378-p NtRDHPstANTVDRT
4 1 T381 DHPstANTVDRTNHQ
4 0 T396-p LENLEAEtAPLP___
0 1 - gap
3451 : Phospho-mu-Opioid Receptor (Ser375) Antibody
  MOR-1 iso5  
S57 TDLGGRDSLCPPTGS
T99 MYVIVRYTKMKTATN
T103 VRYTKMKTATNIYIF
T105 YTKMKTATNIYIFNL
Y108 MKTATNIYIFNLALA
Y168 CTMSVDRYIAVCHPV
T182 VKALDFRTPRNAKII
S263 LMILRLKSVRMLSGS
S268 LKSVRMLSGSKEKDR
S270 SVRMLSGSKEKDRNL
Y338 SCLNPVLYAFLDENF
S357 REFCIPTSSNIEQQN
S358 EFCIPTSSNIEQQNS
N359 FCIPTSSNIEQQNST
S365 SNIEQQNSTRIRQNT
T372 STRIRQNTRDHPSTA
S377 QNTRDHPSTANTVDR
T378 NTRDHPSTANTVDRT
T381 DHPSTANTVDRTNHQ
M395 QPPLAVSMAQIFTRY
K410-m2 PPPTHREkTCNDYMK
  mouse

 
S55-p TGLGGSHsLCPQTGS
T97 MYVIVRYTKMKTATN
T101 VRYTKMKTATNIYIF
T103 YTKMKTATNIYIFNL
Y106 MKTATNIYIFNLALA
Y166 CTMSVDRYIAVCHPV
T180-p VKALDFRtPRNAKIV
S261 LMILRLKSVRMLSGS
S266 LKSVRMLSGSKEKDR
S268 SVRMLSGSKEKDRNL
Y336-p SCLNPVLyAFLDENF
S355 REFCIPTSSTIEQQN
S356 EFCIPTSSTIEQQNs
T357 FCIPTSSTIEQQNsA
S363-p STIEQQNsARIRQNt
T370-p sARIRQNtREHPstA
S375-p QNtREHPstANtVDR
T376-p NtREHPstANtVDRT
T379-p EHPstANtVDRTNHQ
T394 LENLEAETAPLP___
- gap
3451 : Phospho-mu-Opioid Receptor (Ser375) Antibody
  rat

 
S55 TGLGGNDSLCPQTGS
T97-p MYVIVRYtKMKtAtN
T101-p VRYtKMKtAtNIyIF
T103-p YtKMKtAtNIyIFNL
Y106-p MKtAtNIyIFNLALA
Y166-p CTMSVDRyIAVCHPV
T180-p VKALDFRtPRNAKIV
S261-p LMILRLKsVRMLsGS
S266-p LKsVRMLsGSKEKDR
S268 sVRMLsGSKEKDRNL
Y336 SCLNPVLYAFLDENF
S355-p REFCIPTsstIEQQN
S356-p EFCIPTsstIEQQNs
T357-p FCIPTsstIEQQNsT
S363-p stIEQQNsTRVRQNt
T370-p sTRVRQNtREHPsTA
S375-p QNtREHPsTANTVDR
T376 NtREHPsTANTVDRT
T379 EHPsTANTVDRTNHQ
T394-p LENLEAEtAPLP___
- gap
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