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MOR-1
a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral |
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Cellular Component: Golgi apparatus; integral to plasma membrane; endoplasmic reticulum; plasma membrane
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Molecular Function: G-protein coupled receptor activity; voltage-gated calcium channel activity; protein binding; G-protein alpha-subunit binding; beta-endorphin receptor activity
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Biological Process: positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; cellular response to stress; behavior; negative regulation of nitric oxide biosynthetic process; negative regulation of adenylate cyclase activity; locomotory behavior; behavioral response to ethanol; sensory perception of pain; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; reduction of cytosolic calcium ion concentration; sensory perception; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase inhibiting pathway; dopamine receptor, adenylate cyclase activating pathway; regulation of behavior
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Reference #:
P35372 (UniProtKB)
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| Alt. Names/Synonyms: hMOP; KIAA0403; LMOR; M-OR-1; MOP; MOR; MOR-1; MOR1; Mu opiate receptor; Mu opioid receptor; Mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1 |
| Gene Symbols: OPRM1 |
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Molecular weight: 44,779 Da
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Basal Isoelectric point: 8.62
Predict pI for various phosphorylation states
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