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Protein Page:
ADAR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADAR Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.4.-; RNA processing; Hydrolase; Nucleolus
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus
Molecular Function: double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; metal ion binding
Biological Process: base conversion or substitution editing; positive regulation of viral genome replication; response to virus; cytokine and chemokine mediated signaling pathway; adenosine to inosine editing; protein import into nucleus; mRNA modification; innate immune response; gene expression; RNA-mediated gene silencing; protein export from nucleus; mRNA processing; defense response to virus; negative regulation of apoptosis
Reference #:  P55265 (UniProtKB)
Alt. Names/Synonyms: 136 kDa double-stranded RNA binding protein; 136 kDa double-stranded RNA-binding protein; ADAR; ADAR1; adenosine deaminase acting on RNA 1-A; adenosine deaminase, RNA-specific; Double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; interferon-induced protein 4; Interferon-inducible protein 4; K88DSRBP; p136
Gene Symbols: ADAR
Molecular weight: 136,066 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ADAR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p PRQGYSLsGYYtHPF
0 3 T14-p YSLsGYYtHPFQGYE
0 6 R26-m2 GYEHRQLrYQQPGPG
0 1 - gap
0 1 K48 LKQIEFLKGQLPEAP
0 1 Q50 QIEFLKGQLPEAPVI
0 1 R74 SLPGLRPRFPVLLAS
0 1 R91-m1 RGRQVDIrGVPrGVH
0 1 R95-m1 VDIrGVPrGVHLRSQ
0 1 S112-p QRGFQHPsPrGRSLP
0 1 R114-m1 GFQHPsPrGRSLPQR
0 4 Y136-p HFQELSIyQDQEQRI
0 1 - gap
0 1 T167-p DLSGKLGtPKKEINR
0 1 Y177-p KEINRVLySLAKKGK
0 1 S178 EINRVLySLAKKGKL
0 1 T191-p KLQKEAGtPPLWKIA
0 1 D214-ca HSGVVRPdGHSQGAP
0 1 - gap
0 3 S285 PEDSNSTSALEDPLE
0 1 T349-p DVYRQGTtPPIWHLT
0 1 K366-ub KRERMQIkRNTNSVP
0 1 K384-ub PAAIPETkRNAEFLT
0 8 E407 SNNMVTTEKVENGQE
1 1 K418-sm NGQEPVIkLENRQEA
0 4 Y438-p RLKPPVHyNGPSKAG
0 3 Y446-p NGPSKAGyVDFENGQ
0 2 S465-p DIPDDLNsIRAAPGE
0 1 S481-p RAIMEMPsFysHGLP
0 7 Y483-p IMEMPsFysHGLPRC
0 3 S484-p MEMPsFysHGLPRCS
0 1 K495-ub PRCSPYKkLTECQLK
0 2 S553-p FPPAEAGsKKVAKQD
0 1 K558 AGsKKVAKQDAAMKA
0 1 T567-p DAAMKAMtILLEEAk
0 1 K574-ac tILLEEAkAKDsGKS
0 1 S578-p EEAkAKDsGKSEESS
0 1 Y587-p KSEESSHySTEKESE
0 1 K595-ub STEKESEktAEsQtP
0 3 T596-p TEKESEktAEsQtPt
0 4 S599-p ESEktAEsQtPtPsA
0 13 T601-p EktAEsQtPtPsAts
0 6 T603-p tAEsQtPtPsAtsFF
0 1 S605-p EsQtPtPsAtsFFsG
0 1 T607-p QtPtPsAtsFFsGKs
0 1 S608-p tPtPsAtsFFsGKsP
0 2 S611-p PsAtsFFsGKsPVtt
0 6 S614-p tsFFsGKsPVttLLE
0 1 T617-p FsGKsPVttLLECMH
0 1 T618-p sGKsPVttLLECMHK
0 4 S629-p CMHKLGNsCEFRLLs
0 1 S636-p sCEFRLLskEGPAHE
0 2 K637-ub CEFRLLskEGPAHEP
0 17 Y648-p AHEPKFQyCVAVGAQ
0 21 K665-ac PSVSAPSkkVAKQMA
0 1 K665-ub PSVSAPSkkVAKQMA
0 3 K666-ac SVSAPSkkVAKQMAA
0 2 K666-ub SVSAPSkkVAKQMAA
0 1 Y722-p KIGELVRyLNTNPVG
0 1 Y734-p PVGGLLEyARSHGFA
0 1 K757-ub SGPPHEPkFVYQAKV
0 7 T808-p RMGFTEVtPVtGAsL
0 1 T811-p FTEVtPVtGAsLRRt
0 10 S814-p VtPVtGAsLRRtMLL
0 1 T818-p tGAsLRRtMLLLsRs
0 6 S823-p RRtMLLLsRsPEAQP
0 14 S825-p tMLLLsRsPEAQPKT
0 1 S975-p DGALFDKsCSDRAME
0 1 S986-p RAMESTEsRHYPVFE
0 1 S1089-p CRVTRDGsAFEDGLR
0 3 H1097 AFEDGLRHPFIVNHP
0 1 K1105-ac PFIVNHPkVGRVSIY
0 2 K1115-ac RVSIYDSkRQSGKTK
0 2 K1166-ac KNIFLLFkKLCSFRY
  mouse

 
T9 SQGFRGPTGVFPHQT
T16 TGVFPHQTQSYLDPS
R30-m2 SHEHSKWrYPQPQGP
R42-m2 QGPESYPrSFQLQQI
K53-ub LQQIEFLkGrLPEAP
R55-m2 QIEFLkGrLPEAPLI
R79-m2 FLPGHWPrFPGPPAQ
W93 QDRQLEIWEFPRSVT
R97 LEIWEFPRSVTLRNQ
P114 HIGPPLPPPHSRGTP
H116 GPPLPPPHSRGTPWR
S138 HFRELSISQsPEQKV
S140-p RELSISQsPEQKVLN
I169 VLARELRIPKRDINR
Y179 RDINRILYsLEKKGK
S180-p DINRILYsLEKKGKL
K193 KLHRGRGKPPLWSLV
- gap
S231-p RGEPGLDsEDGDPAs
S238-p sEDGDPAsDLEGPSE
T302 DVYRQGATPPIWYLT
K319 KRERLQMKRSTHSAP
T337 PTAVPEATRSPSFPA
K360-ac SSSVAASkRVENGQE
K371 NGQEPAIKHESRHEA
H391 RLRPHAYHNGPSRAG
Y399 NGPSRAGYVASENGQ
S418 DIPDNLNSIHTAPGE
S434 RAIMEMPSFYSPTLP
Y436 IMEMPSFYSPTLPRC
S437 MEMPSFYSPTLPRCS
K448 PRCSPYKKLTECQLK
S506 FPPAEAGSKKVAkQD
K511-ub AGSKKVAkQDAAVKA
A520 DAAVKAMAILLREAK
K527 AILLREAKAKDSGQP
S531 REAKAKDSGQPEDLS
C540 QPEDLSHCPMEEDSE
K548 PMEEDSEKPAEAQAP
P549 MEEDSEKPAEAQAPS
A552 DSEKPAEAQAPSSSA
A554 EKPAEAQAPSSSATS
S556 PAEAQAPSSSATSLF
S558 EAQAPSSSATSLFSG
T560 QAPSSSATSLFSGKS
S561 APSSSATSLFSGKSP
S564 SSATSLFSGKSPVTT
S567 TSLFSGKSPVTTLLE
T570 FSGKSPVTTLLECMH
T571 SGKSPVTTLLECMHK
S582-p CMHKLGNsCEFRLLS
S589 sCEFRLLSKEGPAHD
K590 CEFRLLSKEGPAHDP
Y601 AHDPKFQYCVAVGAQ
K618 PPVSAPSKKVAKQMA
K618 PPVSAPSKKVAKQMA
K619 PVSAPSKKVAKQMAA
K619 PVSAPSKKVAKQMAA
Y671 RIGELVRYLNTNPVG
Y683 PVGGLLEYARSHGFA
K706 SGPPHEPKFVYQAKV
T757 QLGFAEVTPVTGASL
T760 FAEVTPVTGASLRRT
S763 VTPVTGASLRRTMLL
T767 TGASLRRTMLLLSRs
S772 RRTMLLLSRsPDAHP
S774-p TMLLLSRsPDAHPKT
S924 DGALFDKSCSDRAVE
S935 RAVESTESRHYPVFE
K1038 CRVTRDGKAFEDGLR
Y1046-p AFEDGLRyPFIVNHP
K1054 PFIVNHPKVGRVSVY
K1064 RVSVYDSKRQSGKTK
K1115 KNIFLQFKKLCSFRA
  rat

 
T9 SQGFRGPTGVFPHQT
T16 TGVFPHQTQPCLDPS
R30 SYEHSKWRYLQPRGS
R42 RGSESYLRSFQLQQI
K53 LQQIEFLKGRLPEAP
R55 QIEFLKGRLPEAPLI
R79 FLPGHWPRFPGPPAQ
W93 QGKQPEIWGFPRSVT
R97 PEIWGFPRSVTLRNQ
P114 HIGPPLPPPHSRGPP
H116 GPPLPPPHSRGPPWR
S138 HFQELSISQNPEQKV
N140 QELSISQNPEQKVLN
T169 ALARELRTPKKDINR
Y179 KDINRILYSLERKGK
S180 DINRILYSLERKGKL
K193 KLHRGVGKPPLWSLV
- gap
S228 RGEPDLDSEDGDPAS
S235 SEDGDPASDLEGPSE
T299 DVYREGATPPIWYLT
K316 KRERLQMKRSTHSGP
T334 PAAVSEATQSTSFPT
K357 SSSMATSKRVENGQE
K368 NGQEPVTKYESRHEA
H388 RLRPHAYHNGPSRAG
Y396 NGPSRAGYVASENGP
S415 DIPDNLNSIHTAPGE
S431 RAIMEMPSFYSPTLP
Y433 IMEMPSFYSPTLPRC
S434 MEMPSFYSPTLPRCS
K445 PRCSPYKKLTECQLK
S503 FPPAEAGSKKVAKQD
K508 AGSKKVAKQDAAVKA
A517 DAAVKAMAILLREAK
K524 AILLREAKAKDSGQP
S528 REAKAKDSGQPEELS
C537 QPEELSNCPMEEDPE
K545 PMEEDPEKPAESQPP
P546 MEEDPEKPAESQPPS
S549 DPEKPAESQPPSSSA
P551 EKPAESQPPSSSATS
S553 PAESQPPSSSATSLF
S555 ESQPPSSSATSLFSG
T557 QPPSSSATSLFSGKS
S558 PPSSSATSLFSGKSP
S561 SSATSLFSGKSPVTT
S564 TSLFSGKSPVTTLLE
T567 FSGKSPVTTLLECMH
T568 SGKSPVTTLLECMHK
S579 CMHKLGNSCEFRLLS
S586 SCEFRLLSKEGPAHD
K587 CEFRLLSKEGPAHDP
Y598 AHDPKFQYCVAVGAQ
K615 PSVSAPSKKVAKQMA
K615 PSVSAPSKKVAKQMA
K616 SVSAPSKKVAKQMAA
K616 SVSAPSKKVAKQMAA
Y668 RIGELVRYLNTNPVG
Y680 PVGGLLEYARSHGFA
K703 SGPPHEPKFVYQAKV
T754 QLGFAEVTPVTGASL
T757 FAEVTPVTGASLRRT
S760 VTPVTGASLRRTMLL
T764 TGASLRRTMLLLSRS
S769 RRTMLLLSRSPDAHP
S771 TMLLLSRSPDAHPKT
S921 DGAHFDKSCSDRAVE
S932 RAVESTESRHYPVFE
N1035 CRVTRDGNAFEDGLR
Y1043 AFEDGLRYPFIVNHP
K1051 PFIVNHPKVGRVSVY
K1061 RVSVYDSKRQSGKTK
K1112 KNIFLQFKKLCSFRA
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