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moesin (human)

Overview moesin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: filopodium membrane; internal side of plasma membrane; focal adhesion; cell surface; microvillus; secretory granule membrane; basolateral plasma membrane; extrinsic to membrane; cytoskeleton; microvillus membrane; apical part of cell; apical plasma membrane; cytoplasm; plasma membrane; nucleolus; uropod; nucleus; filopodium Molecular Function: protein binding; structural constituent of cytoskeleton; cell adhesion molecule binding; actin binding; protein kinase binding; receptor binding Biological Process: leukocyte adhesion; membrane to membrane docking; cell motility; leukocyte migration Reference #:  P26038 (UniProtKB) Alt. Names/Synonyms: Membrane-organizing extension spike protein; MOES; Moesin; MSN Gene Symbols: MSN Molecular weight: 67,820 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below moesin 1E5W - A=1-346 (human) 1EF1 - A/B=4-297, C/D=488-577 (human) 1SGH - A=1-297 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E5W 1EF1 1SGH  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: T558‑p cytoskeletal reorganization: T558‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3-u	_____MPktISVRVT
0	1		T4-p	____MPktISVRVTT
0	4		K35-u	QLFDQVVkTIGLREV
0	1		S56	YQDTKGFStWLKLNK
0	4		T57-p	QDTKGFStWLKLNKk
0	1		K60	KGFStWLKLNKkVtA
0	1		K64-a	tWLKLNKkVtAQDVR
0	1		T66-p	LKLNKkVtAQDVRkE
0	8		K72-u	VtAQDVRkEsPLLFk
0	2		S74-p	AQDVRkEsPLLFkFR
0	1		K79-a	kEsPLLFkFRAkFYP
0	34		K79-u	kEsPLLFkFRAkFYP
0	23		K83-u	LLFkFRAkFYPEDVS
0	1		T98-p	EELIQDItQRLFFLQ
0	2		K107-u	RLFFLQVkEGILNDD
0	42		Y116-p	GILNDDIyCPPETAV
0	1		K133-a	ASYAVQSkYGDFNkE
0	1		K133	ASYAVQSKYGDFNkE
0	1		K139-a	SkYGDFNkEVHKSGy
0	21		K139-u	SkYGDFNkEVHKSGy
0	1		K143	DFNkEVHKSGyLAGD
0	1		S144	FNkEVHKSGyLAGDk
0	2		Y146-p	kEVHKSGyLAGDkLL
0	3		K151-u	SGyLAGDkLLPQRVL
0	34		K162-u	QRVLEQHkLNkDQWE
0	7		K165-u	LEQHkLNkDQWEERI
0	10		K209-u	GVNYFSIkNkkGSEL
0	3		K211-u	NYFSIkNkkGSELWL
0	3		K212-u	YFSIkNkkGSELWLG
0	1		Y228-p	DALGLNIyEQNDRLT
0	7		K237-u	QNDRLTPkIGFPWSE
0	27		K253-a	RNISFNDkKFVIKPI
0	3		K253-u	RNISFNDkKFVIKPI
0	1		K254	NISFNDkKFVIKPID
0	7		K263-u	VIKPIDKkAPDFVFy
0	243		Y270-p	kAPDFVFyAPRLRIN
0	14		Y291-p	CMGNHELyMRRRKPD
0	3		K306-u	TIEVQQMkAQAREEK
0	1		R350	EKEELMERLkQIEEQ
0	34		K352-u	EELMERLkQIEEQTK
0	1		K360	QIEEQTKKAQQELEE
0	2		S384-p	QERKRAQsEAEkLAk
0	1		K388-a	RAQsEAEkLAkERQE
0	1		K391-u	sEAEkLAkERQEAEE
0	2		S407-p	KEALLQAsRDQKKtQ
0	1		T413-p	AsRDQKKtQEQLALE
0	1		L419	KtQEQLALEMAELtA
0	9		T425-p	ALEMAELtARIsQLE
0	19		S429-p	AELtARIsQLEMARQ
0	4		K448-u	EAVEWQQkAQMVQED
0	11		K458-u	MVQEDLEkTRAELkt
0	15		K464-u	EkTRAELktAMstPH
0	1		T465-p	kTRAELktAMstPHV
0	3		S468-p	AELktAMstPHVAEP
0	6		T469-p	ELktAMstPHVAEPA
0	33		K523-u	ERVQKHLkALtsELA
0	1		T526-p	QKHLkALtsELANAR
0	1		S527-p	KHLkALtsELANARD
0	1		K537	ANARDESKkTANDMI
0	2		K538-u	NARDESKkTANDMIH
0	15		Y556-p	MRLGRDKyKtLRQIR
27	29		T558-p	LGRDKyKtLRQIRQG
0	38		S576-p	QRIDEFEsM______

	mouse
K3	_____MPKTISVRVT
T4	____MPKTISVRVTT
K35	QLFDQVVKTIGLREV
S56-p	YQDTKAFstWLkLNK
T57-p	QDTKAFstWLkLNKK
K60-u	KAFstWLkLNKKVTA
K64	tWLkLNKKVTAQDVR
T66	LkLNKKVTAQDVRkE
K72-u	VTAQDVRkEsPLLFk
S74-p	AQDVRkEsPLLFkFR
K79	kEsPLLFKFRAkFYP
K79-u	kEsPLLFkFRAkFYP
K83-u	LLFkFRAkFYPEDVS
T98	EELIQDITQRLFFLQ
K107	RLFFLQVKEGILNDD
Y116-p	GILNDDIyCPPETAV
K133	ASYAVQSKYGDFNkE
K133-u	ASYAVQSkYGDFNkE
K139	SkYGDFNKEVHksGy
K139-u	SkYGDFNkEVHksGy
K143-u	DFNkEVHksGyLAGD
S144-p	FNkEVHksGyLAGDK
Y146-p	kEVHksGyLAGDKLL
K151	sGyLAGDKLLPQRVL
K162-u	QRVLEQHkLNkDQWE
K165-u	LEQHkLNkDQWEERI
K209-u	GVNYFSIkNkKGSEL
K211-u	NYFSIkNkKGSELWL
K212	YFSIkNkKGSELWLG
Y228	DALGLNIYEQNDRLT
K237-u	QNDRLTPkIGFPWSE
K253-a	RNISFNDkkFVIKPI
K253-u	RNISFNDkkFVIKPI
K254-a	NISFNDkkFVIKPID
K263-u	VIKPIDKkAPDFVFy
Y270-p	kAPDFVFyAPRLRIN
Y291-p	CMGNHELyMRRRKPD
K306-u	TIEVQQMkAQAREEK
K350-u	EKEELMEkLkQIEEQ
K352-u	EELMEkLkQIEEQTK
K360-u	QIEEQTKkAQQELEE
S384	QERKRAQSEAEKLAK
K388	RAQSEAEKLAKERQE
K391	SEAEKLAKERQEAEE
S407-p	KEALLQAsRDQKKTQ
T413	AsRDQKKTQEQLAsE
S419-p	KTQEQLAsEMAELTA
T425	AsEMAELTARIsQLE
S429-p	AELTARIsQLEMARK
K448-u	EAVEWQQkAQMVQED
K458-u	MVQEDLEkTRAELkt
K464-u	EkTRAELktAMstPH
T465-p	kTRAELktAMstPHV
S468-p	AELktAMstPHVAEP
T469-p	ELktAMstPHVAEPA
K523-u	ERVQKHLkALtsELA
T526-p	QKHLkALtsELANAR
S527-p	KHLkALtsELANARD
K537-u	ANARDESkkTANDMI
K538-u	NARDESkkTANDMIH
Y556	MRLGRDKYKtLRQIR
T558-p	LGRDKYKtLRQIRQG
S576-p	QRIDEFEsM______

	rat
K3	_____MPKTISVRVT
T4	____MPKTISVRVTT
K35	QLFDQVVKTIGLREV
S56	YQDTKAFSTWLKLNK
T57	QDTKAFSTWLKLNKK
K60	KAFSTWLKLNKKVTA
K64	TWLKLNKKVTAQDVR
T66	LKLNKKVTAQDVRKE
K72	VTAQDVRKESPLLFK
S74	AQDVRKESPLLFKFR
K79	KESPLLFKFRAKFYP
K79	KESPLLFKFRAKFYP
K83	LLFKFRAKFYPEDVS
T98	EELIQDITQRLFFLQ
K107	RLFFLQVKEGILNDD
Y116	GILNDDIYCPPETAV
K133	ASYAVQSKYGDFNKE
K133	ASYAVQSKYGDFNKE
K139	SKYGDFNKEVHKSGY
K139	SKYGDFNKEVHKSGY
K143	DFNKEVHKSGYLAGD
S144	FNKEVHKSGYLAGDK
Y146	KEVHKSGYLAGDKLL
K151	SGYLAGDKLLPQRVL
K162	QRVLEQHKLNKDQWE
K165	LEQHKLNKDQWEERI
K209	GVNYFSIKNKKGSEL
K211	NYFSIKNKKGSELWL
K212	YFSIKNKKGSELWLG
Y228	DALGLNIYEQNDRLT
K237	QNDRLTPKIGFPWSE
K253	RNISFNDKKFVIKPI
K253	RNISFNDKKFVIKPI
K254	NISFNDKKFVIKPID
K263	VIKPIDKKAPDFVFy
Y270-p	KAPDFVFyAPRLRIN
Y291	CMGNHELYMRRRKPD
K306	TIEVQQMKAQAREEK
K350	EKEELMEKLKQIEEQ
K352	EELMEKLKQIEEQTK
K360	QIEEQTKKAQQELEE
S384-p	QERKRAQsEAEKLAK
K388	RAQsEAEKLAKERQE
K391	sEAEKLAKERQEAEE
S407	KEALLQASRDQKKTQ
T413	ASRDQKKTQEQLASE
S419	KTQEQLASEMAELTA
T425	ASEMAELTARVSQLE
S429	AELTARVSQLEMARK
K448	EAEECHQKAQMVQED
K458	MVQEDLEKTRAELKT
K464	EKTRAELKTAMSTPH
T465	KTRAELKTAMSTPHV
S468	AELKTAMSTPHVAEP
T469	ELKTAMSTPHVAEPA
K523	ERVQKHLKALTSELA
T526	QKHLKALTSELANAR
S527	KHLKALTSELANARD
K537	ANARDESKKTTNDMI
K538	NARDESKKTTNDMIH
Y556	MRLGRDKYKtLRQIR
T558-p	LGRDKYKtLRQIRQG
S576	QRIDEFESM______

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