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Protein Page:
Moesin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Moesin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: extracellular space; extrinsic to membrane; focal adhesion; microvillus; cytoskeleton; apical part of cell; basolateral plasma membrane; microvillus membrane; apical plasma membrane; cytoplasm; plasma membrane; uropod; filopodium
Molecular Function: protein binding; structural constituent of cytoskeleton; double-stranded RNA binding; cell adhesion molecule binding; actin binding; protein kinase binding; receptor binding
Biological Process: leukocyte adhesion; membrane to membrane docking; cell motility; leukocyte migration
Reference #:  P26038 (UniProtKB)
Alt. Names/Synonyms: Membrane-organizing extension spike protein; MOES; Moesin; MSN
Gene Symbols: MSN
Molecular weight: 67,820 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Moesin

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: T558‑p
cytoskeletal reorganization: T558‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3-ub _____MPktISVRVT
0 1 T4-p ____MPktISVRVTT
0 2 K35-ac QLFDQVVkTIGLREV
0 4 K35-ub QLFDQVVkTIGLREV
0 2 S56 YQDTKGFStWLKLNK
0 4 T57-p QDTKGFStWLKLNKk
0 1 K60 KGFStWLKLNKkVtA
0 1 K64-ac tWLKLNKkVtAQDVR
1 1 T66-p LKLNKkVtAQDVRkE
0 8 K72-ub VtAQDVRkEsPLLFk
0 6 S74-p AQDVRkEsPLLFkFR
0 1 K79-ac kEsPLLFkFRAkFYP
0 34 K79-ub kEsPLLFkFRAkFYP
0 1 K79-sc kEsPLLFkFRAkFYP
0 1 K83-ac LLFkFRAkFYPEDVS
0 23 K83-ub LLFkFRAkFYPEDVS
0 1 T98-p EELIQDItQRLFFLQ
0 2 K107-ub RLFFLQVkEGILNDD
0 42 Y116-p GILNDDIyCPPETAV
0 1 S127-p ETAVLLAsYAVQskY
0 1 S132-p LAsYAVQskYGDFNk
0 1 K133-ac AsYAVQskYGDFNkE
0 1 K133 AsYAVQsKYGDFNkE
0 1 K139-ac skYGDFNkEVHKSGy
0 21 K139-ub skYGDFNkEVHKSGy
0 1 K143 DFNkEVHKSGyLAGD
0 1 S144 FNkEVHKSGyLAGDk
0 2 Y146-p kEVHKSGyLAGDkLL
0 1 K151-ac SGyLAGDkLLPQRVL
0 3 K151-ub SGyLAGDkLLPQRVL
0 34 K162-ub QRVLEQHkLNkDQWE
0 1 K165 LEQHkLNKDQWEERI
0 7 K165-ub LEQHkLNkDQWEERI
0 1 K165-sc LEQHkLNkDQWEERI
0 10 K209-ub GVNYFSIkNkkGSEL
0 3 K211-ub NYFSIkNkkGSELWL
0 3 K212-ub YFSIkNkkGSELWLG
0 1 Y228-p DALGLNIyEQNDRLT
0 7 K237-ub QNDRLTPkIGFPWsE
0 1 S243-p PkIGFPWsEIRNISF
0 27 K253-ac RNISFNDkKFVIkPI
0 3 K253-ub RNISFNDkKFVIkPI
0 1 K254 NISFNDkKFVIkPID
0 1 K258-ac NDkKFVIkPIDKkAP
0 7 K263-ub VIkPIDKkAPDFVFy
0 253 Y270-p kAPDFVFyAPRLRIN
0 14 Y291-p CMGNHELyMRRRKPD
0 3 K306-ub TIEVQQMkAQAREEK
0 1 K327-sc RAMLENEkKKREMAE
0 1 K344-ac KEKIEREkEELMERL
0 1 R350 EkEELMERLkQIEEQ
0 34 K352-ub EELMERLkQIEEQTK
0 1 K360 QIEEQTKKAQQELEE
0 5 S384-p QERKRAQsEAEkLAk
0 1 K388-ac RAQsEAEkLAkERQE
0 1 K391-ub sEAEkLAkERQEAEE
0 5 S407-p KEALLQAsRDQKKtQ
0 1 T413-p AsRDQKKtQEQLALE
0 1 L419 KtQEQLALEMAELtA
0 9 T425-p ALEMAELtARIsQLE
0 22 S429-p AELtARIsQLEMARQ
0 4 K448-ub EAVEWQQkAQMVQED
0 11 K458-ub MVQEDLEkTRAELkt
0 15 K464-ub EkTRAELktAMstPH
0 1 T465-p kTRAELktAMstPHV
0 3 S468-p AELktAMstPHVAEP
0 6 T469-p ELktAMstPHVAEPA
0 2 S491-p DENGAEAsADLRADA
0 33 K523-ub ERVQKHLkALtsELA
0 2 T526-p QKHLkALtsELANAR
0 7 S527-p KHLkALtsELANARD
0 1 K537 ANARDESKkTANDMI
0 2 K538-ub NARDESKkTANDMIH
0 16 Y556-p MRLGRDKyKtLRQIR
29 33 T558-p LGRDKyKtLRQIRQG
0 47 S576-p QRIDEFEsM______
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
  mouse

 
K3 _____MPKTISVRVT
T4 ____MPKTISVRVTT
K35 QLFDQVVKTIGLREV
K35 QLFDQVVKTIGLREV
S56-p YQDTKAFstWLkLNK
T57-p QDTKAFstWLkLNKK
K60-ub KAFstWLkLNKKVTA
K64 tWLkLNKKVTAQDVR
T66 LkLNKKVTAQDVRkE
K72-ub VTAQDVRkEsPLLFk
S74-p AQDVRkEsPLLFkFR
K79 kEsPLLFKFRAkFYP
K79-ub kEsPLLFkFRAkFYP
K79 kEsPLLFKFRAkFYP
K83 LLFkFRAKFYPEDVS
K83-ub LLFkFRAkFYPEDVS
T98 EELIQDITQRLFFLQ
K107 RLFFLQVKEGILNDD
Y116-p GILNDDIyCPPETAV
S127 ETAVLLASYAVQSkY
S132 LASYAVQSkYGDFNk
K133 ASYAVQSKYGDFNkE
K133-ub ASYAVQSkYGDFNkE
K139 SkYGDFNKEVHksGy
K139-ub SkYGDFNkEVHksGy
K143-ub DFNkEVHksGyLAGD
S144-p FNkEVHksGyLAGDK
Y146-p kEVHksGyLAGDKLL
K151 sGyLAGDKLLPQRVL
K151 sGyLAGDKLLPQRVL
K162-ub QRVLEQHkLNkDQWE
K165-ac LEQHkLNkDQWEERI
K165-ub LEQHkLNkDQWEERI
K165 LEQHkLNKDQWEERI
K209-ub GVNYFSIkNkKGSEL
K211-ub NYFSIkNkKGSELWL
K212 YFSIkNkKGSELWLG
Y228 DALGLNIYEQNDRLT
K237-ub QNDRLTPkIGFPWSE
S243 PkIGFPWSEIRNISF
K253-ac RNISFNDkkFVIKPI
K253-ub RNISFNDkkFVIKPI
K254-ac NISFNDkkFVIKPID
K258 NDkkFVIKPIDKkAP
K263-ub VIKPIDKkAPDFVFy
Y270-p kAPDFVFyAPRLRIN
Y291-p CMGNHELyMRRRKPD
K306-ub TIEVQQMkAQAREEK
K327 RALLENEKKKRELAE
K344 KEKIEREKEELMEkL
K350-ub EKEELMEkLkQIEEQ
K352-ub EELMEkLkQIEEQTK
K360-ub QIEEQTKkAQQELEE
S384-p QERKRAQsEAEKLAK
K388 RAQsEAEKLAKERQE
K391 sEAEKLAKERQEAEE
S407-p KEALLQAsRDQKKTQ
T413 AsRDQKKTQEQLAsE
S419-p KTQEQLAsEMAELTA
T425 AsEMAELTARIsQLE
S429-p AELTARIsQLEMARK
K448-ub EAVEWQQkAQMVQED
K458-ub MVQEDLEkTRAELkt
K464-ub EkTRAELktAMstPH
T465-p kTRAELktAMstPHV
S468-p AELktAMstPHVAEP
T469-p ELktAMstPHVAEPA
S491-p DENGAEAsAELRADA
K523-ub ERVQKHLkALtsELA
T526-p QKHLkALtsELANAR
S527-p KHLkALtsELANARD
K537-ub ANARDESkkTANDMI
K538-ub NARDESkkTANDMIH
Y556 MRLGRDKYKtLRQIR
T558-p LGRDKYKtLRQIRQG
S576-p QRIDEFEsM______
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
  rat

 
K3 _____MPKTISVRVT
T4 ____MPKTISVRVTT
K35-ac QLFDQVVkTIGLREV
K35 QLFDQVVKTIGLREV
S56-p YQDTKAFstWLKLNK
T57-p QDTKAFstWLKLNKK
K60 KAFstWLKLNKKVTA
K64 tWLKLNKKVTAQDVR
T66 LKLNKKVTAQDVRKE
K72 VTAQDVRKESPLLFk
S74 AQDVRKESPLLFkFR
K79-ac KESPLLFkFRAkFYP
K79 KESPLLFKFRAkFYP
K79 KESPLLFKFRAkFYP
K83-ac LLFkFRAkFYPEDVS
K83 LLFkFRAKFYPEDVS
T98 EELIQDITQRLFFLQ
K107 RLFFLQVKEGILNDD
Y116 GILNDDIYCPPETAV
S127 ETAVLLASYAVQSKY
S132 LASYAVQSKYGDFNk
K133 ASYAVQSKYGDFNkE
K133 ASYAVQSKYGDFNkE
K139-ac SKYGDFNkEVHKSGY
K139 SKYGDFNKEVHKSGY
K143 DFNkEVHKSGYLAGD
S144 FNkEVHKSGYLAGDk
Y146 kEVHKSGYLAGDkLL
K151-ac SGYLAGDkLLPQRVL
K151 SGYLAGDKLLPQRVL
K162 QRVLEQHKLNkDQWE
K165-ac LEQHKLNkDQWEERI
K165 LEQHKLNKDQWEERI
K165 LEQHKLNKDQWEERI
K209 GVNYFSIKNKKGSEL
K211 NYFSIKNKKGSELWL
K212 YFSIKNKKGSELWLG
Y228 DALGLNIYEQNDRLT
K237 QNDRLTPKIGFPWsE
S243-p PKIGFPWsEIRNISF
K253-ac RNISFNDkkFVIkPI
K253 RNISFNDKkFVIkPI
K254-ac NISFNDkkFVIkPID
K258-ac NDkkFVIkPIDKKAP
K263 VIkPIDKKAPDFVFy
Y270-p KAPDFVFyAPRLRIN
Y291 CMGNHELYMRRRKPD
K306 TIEVQQMKAQAREEK
K327 RALLENEKKKRELAE
K344-ac KEKIEREkEELMEKL
K350 EkEELMEKLKQIEEQ
K352 EELMEKLKQIEEQTK
K360 QIEEQTKKAQQELEE
S384-p QERKRAQsEAEkLAK
K388-ac RAQsEAEkLAKERQE
K391 sEAEkLAKERQEAEE
S407-p KEALLQAsRDQKKTQ
T413 AsRDQKKTQEQLASE
S419 KTQEQLASEMAELTA
T425 ASEMAELTARVSQLE
S429 AELTARVSQLEMARK
K448 EAEECHQKAQMVQED
K458 MVQEDLEKTRAELKT
K464 EKTRAELKTAMSTPH
T465 KTRAELKTAMSTPHV
S468 AELKTAMSTPHVAEP
T469 ELKTAMSTPHVAEPA
S491 DENGAEASAELRADA
K523 ERVQKHLKALTSELA
T526 QKHLKALTSELANAR
S527 KHLKALTSELANARD
K537 ANARDESKKTTNDMI
K538 NARDESKKTTNDMIH
Y556 MRLGRDKYKtLRQIR
T558-p LGRDKYKtLRQIRQG
S576-p QRIDEFEsM______
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
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