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Protein Page:
DYRK1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DYRK1A a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a strong candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; Kinase, protein; EC 2.7.12.2; Protein kinase, CMGC; CMGC group; DYRK family; Dyrk1 subfamily
Cellular Component: nucleoplasm; nuclear speck; nucleus; ribonucleoprotein complex
Molecular Function: protein serine/threonine kinase activity; protein binding; protein self-association; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; tau protein binding; ATP binding; protein kinase activity
Biological Process: circadian rhythm; nervous system development; negative regulation of DNA damage response, signal transduction by p53 class mediator; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; mitotic cell cycle; protein amino acid phosphorylation
Reference #:  Q13627 (UniProtKB)
Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYR1A; DYRK; DYRK1; DYRK1A; hMNB; HP86; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; Protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Symbols: DYRK1A
Molecular weight: 85,584 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DYRK1A

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: S529‑p
molecular association, regulation: S529‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S14-p TSACKPSsVRLAPSF
0 2 S22-p VRLAPSFsFHAAGLQ
0 1 N47 YSDRRQPNISDQQVS
0 1 S49 DRRQPNISDQQVSAL
0 1 S57 DQQVSALSYSDQIQQ
0 1 Y104 SVDLIKTYKHINEVy
0 25 Y111-p YKHINEVyYAKKKRR
0 1 Y136-p HKKERKVyNDGYDDD
1 896 Y145-p DGYDDDNyDyIVKNG
1 20 Y147-p YDDDNyDyIVKNGEK
0 5 Y159-p GEKWMDRyEIDSLIG
1 0 Y219 KHDTEMKYYIVHLKR
1 187 Y319-p CQLGQRIyQyIQsRF
5 3712 Y321-p LGQRIyQyIQsRFYR
0 373 S324-p RIyQyIQsRFYRSPE
0 2 K453-ub VADYLKFkDLILRML
2 2 S529-p SNSGRARsDPTHQHR
0 2 S538-p PTHQHRHsGGHFTAA
0 3 S555-p AMDCETHsPQVRQQF
0 4 Y705-p MDVNLTVysNPRQET
0 1 S706-p DVNLTVysNPRQETG
0 9 S748-p QGADREEsPMTGVCV
0 22 S758-p TGVCVQQsPVAsS__
0 1 S762-p VQQsPVAsS______
  DYRK1A iso2  
S14 TSACKPSSVRLAPSF
S22 VRLAPSFSFHAAGLQ
N47 YSDRRQPNISDQQVS
S49 DRRQPNISDQQVSAL
S57-p DQQVSALsYSDQIQQ
Y95 SVDLIKTYKHINEVY
Y102 YKHINEVYYAKKKRR
Y127 HKKERKVYNDGYDDD
Y136-p DGYDDDNyDYIVKNG
Y138 YDDDNyDYIVKNGEK
Y150 GEKWMDRYEIDSLIG
Y210 KHDTEMKYYIVHLKR
Y310 CQLGQRIYQYIQSRF
Y312 LGQRIYQYIQSRFYR
S315 RIYQYIQSRFYRSPE
K444 VADYLKFKDLILRML
S520 SNSGRARSDPTHQHR
S529 PTHQHRHSGGHFTAA
S546 AMDCETHSPQVRQQF
Y696 MDVNLTVYSNPRQET
S697 DVNLTVYSNPRQETG
S739 QGADREESPMTGVCV
S749 TGVCVQQSPVASS__
S753 VQQSPVASS______
  DYRK1A iso4  
S14 TSACKPSSVRLAPSF
S22 VRLAPSFSFHAAGLQ
N47 YSDRRQPNISDQQVS
S49 DRRQPNISDQQVSAL
S57 DQQVSALSYSDQIQQ
Y104 SVDLIKTYKHINEVY
Y111 YKHINEVYYAKKKRR
Y136 HKKERKVYNDGYDDD
Y145-p DGYDDDNyDyIVKNG
Y147-p YDDDNyDyIVKNGEK
Y159 GEKWMDRYEIDSLIG
Y219 KHDTEMKYYIVHLKR
Y319-p CQLGQRIyQyIQSRF
Y321-p LGQRIyQyIQSRFYR
S324 RIyQyIQSRFYRSPE
K453 VADYLKFKDLILRML
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S14 TSACKPSSVRLAPSF
S22-p VRLAPSFsFHAAGLQ
S47-p YSDRRQPsIsDQQVS
S49-p DRRQPsIsDQQVSAL
P57 DQQVSALPYSDQIQQ
Y104 SVDLIKTYKHINEVy
Y111-p YKHINEVyYAKKKRR
Y136 HKKERKVYNDGYDDD
Y145-p DGYDDDNyDyIVKNG
Y147-p YDDDNyDyIVKNGEK
Y159 GEKWMDRYEIDSLIG
Y219 KHDTEMKYYIVHLKR
Y319-p CQLGQRIyQyIQsRF
Y321-p LGQRIyQyIQsRFYR
S324-p RIyQyIQsRFYRSPE
K453-ub VADYLKFkDLILRML
S529-p SNSGRARsDPTHQHR
S538-p PTHQHRHsGGHFAAA
S555-p AMDCETHsPQVRQQF
Y705 MDVNLTVYSNPRQET
S706 DVNLTVYSNPRQETG
S748-p QGADREEsPMTGVCV
S758-p TGVCVQQsPVASS__
S762 VQQsPVASS______
  rat

 
S14 TSACKPSSVRLAPSF
S22 VRLAPSFSFHAAGLQ
N47 YSDRRQPNISDQQVS
S49 DRRQPNISDQQVSAL
S57 DQQVSALSYSDQIQQ
Y104-p SVDLIKTyKHINEVy
Y111-p yKHINEVyYAKKKRR
Y136 HKKERKVYNDGYDDD
Y145-p DGYDDDNyDyIVKNG
Y147-p YDDDNyDyIVKNGEK
Y159 GEKWMDRYEIDSLIG
Y219-p KHDTEMKyYIVHLKR
Y319-p CQLGQRIyQyIQsRF
Y321-p LGQRIyQyIQsRFYR
S324-p RIyQyIQsRFYRSPE
K453 VADYLKFKDLILRML
S529 SNSGRARSDPTHQHR
S538 PTHQHRHSGGHFAAA
S555 AMDCETHSPQVRQQF
Y705 MDVNLTVYSNPRQET
S706 DVNLTVYSNPRQETG
S748 QGADREESPMTGVCV
S758 TGVCVQQSPVASS__
S762 VQQSPVASS______
  rabbit

 
- gap
- gap
S3 _____QPSISDQQVS
S5 ___QPSISDQQVSAL
- gap
- gap
- gap
- gap
- gap
- gap
Y41 QRRWMDRYEIDSLIG
Y76 RHDTEMKYYIVHLKI
- gap
- gap
- gap
K144 GGPGGRFKDLILRML
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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