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DYRK1A (human)

Overview DYRK1A a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a strong candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; Protein kinase, dual-specificity; EC 2.7.12.2; CMGC group; DYRK family; Dyrk1 subfamily Cellular Component: nucleoplasm; nuclear speck; ribonucleoprotein complex; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; protein self-association; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; tau protein binding; ATP binding; protein kinase activity Biological Process: nervous system development; negative regulation of DNA damage response, signal transduction by p53 class mediator; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; mitotic cell cycle; protein amino acid phosphorylation Reference #:  Q13627 (UniProtKB) Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYR1A; DYRK; DYRK1; DYRK1A; hMNB; HP86; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; Protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase Gene Symbols: DYRK1A Molecular weight: 85,584 Da Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DYRK1A 2VX3 - A/D/C/B=127-485 (human) 2WO6 - A/B=127-485 (human) 3ANQ - A/D/C/B=126-490 (human) 3ANR - A/D/C/B=126-490 (human) 4AZE - A/C/B=128-485 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2VX3 2WO6 3ANQ 3ANR 4AZE  |  ENZYME 2.7.12.1 2.7.12.2  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S529‑p molecular association, regulation: S529‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S22	VRLAPSFSFHAAGLQ
0	1		S57	DQQVSALSYSDQIQQ
0	1		Y104	SVDLIKTYKHINEVy
0	25		Y111-p	YKHINEVyYAKKKRR
0	1		Y136-p	HKKERKVyNDGYDDD
1	907		Y145-p	DGYDDDNyDyIVKNG
1	20		Y147-p	YDDDNyDyIVKNGEK
0	5		Y159-p	GEKWMDRyEIDSLIG
1	0		Y219	KHDTEMKYYIVHLKR
1	194		Y319-p	CQLGQRIyQyIQsRF
3	3719		Y321-p	LGQRIyQyIQsRFYR
0	363		S324-p	RIyQyIQsRFYRSPE
0	2		K453-u	VADYLKFkDLILRML
2	0		S529-p	SNSGRARsDPTHQHR
0	2		S538-p	PTHQHRHsGGHFTAA
0	2		S555-p	AMDCETHsPQVRQQF
0	4		Y705-p	MDVNLTVysNPRQET
0	1		S706-p	DVNLTVysNPRQETG
0	7		S748-p	QGADREEsPMTGVCV
0	16		S758-p	TGVCVQQsPVASS__

	DYRK1A iso2
S22	VRLAPSFSFHAAGLQ
S57-p	DQQVSALsYSDQIQQ
Y95	SVDLIKTYKHINEVY
Y102	YKHINEVYYAKKKRR
Y127	HKKERKVYNDGYDDD
Y136-p	DGYDDDNyDYIVKNG
Y138	YDDDNyDYIVKNGEK
Y150	GEKWMDRYEIDSLIG
Y210	KHDTEMKYYIVHLKR
Y310	CQLGQRIYQYIQSRF
Y312	LGQRIYQYIQSRFYR
S315	RIYQYIQSRFYRSPE
K444	VADYLKFKDLILRML
S520	SNSGRARSDPTHQHR
S529	PTHQHRHSGGHFTAA
S546	AMDCETHSPQVRQQF
Y696	MDVNLTVYSNPRQET
S697	DVNLTVYSNPRQETG
S739	QGADREESPMTGVCV
S749	TGVCVQQSPVASS__

	DYRK1A iso4
S22	VRLAPSFSFHAAGLQ
S57	DQQVSALSYSDQIQQ
Y104	SVDLIKTYKHINEVY
Y111	YKHINEVYYAKKKRR
Y136	HKKERKVYNDGYDDD
Y145-p	DGYDDDNyDyIVKNG
Y147-p	YDDDNyDyIVKNGEK
Y159	GEKWMDRYEIDSLIG
Y219	KHDTEMKYYIVHLKR
Y319-p	CQLGQRIyQyIQSRF
Y321-p	LGQRIyQyIQSRFYR
S324	RIyQyIQSRFYRSPE
K453	VADYLKFKDLILRML
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
S22-p	VRLAPSFsFHAAGLQ
P57	DQQVSALPYSDQIQQ
Y104	SVDLIKTYKHINEVy
Y111-p	YKHINEVyYAKKKRR
Y136	HKKERKVYNDGYDDD
Y145-p	DGYDDDNyDyIVKNG
Y147-p	YDDDNyDyIVKNGEK
Y159	GEKWMDRYEIDSLIG
Y219	KHDTEMKYYIVHLKR
Y319-p	CQLGQRIyQyIQsRF
Y321-p	LGQRIyQyIQsRFYR
S324-p	RIyQyIQsRFYRSPE
K453-u	VADYLKFkDLILRML
S529	SNSGRARSDPTHQHR
S538-p	PTHQHRHsGGHFAAA
S555-p	AMDCETHsPQVRQQF
Y705	MDVNLTVYSNPRQET
S706	DVNLTVYSNPRQETG
S748-p	QGADREEsPMTGVCV
S758-p	TGVCVQQsPVASS__

	rat
S22	VRLAPSFSFHAAGLQ
S57	DQQVSALSYSDQIQQ
Y104-p	SVDLIKTyKHINEVy
Y111-p	yKHINEVyYAKKKRR
Y136	HKKERKVYNDGYDDD
Y145-p	DGYDDDNyDyIVKNG
Y147-p	YDDDNyDyIVKNGEK
Y159	GEKWMDRYEIDSLIG
Y219-p	KHDTEMKyYIVHLKR
Y319-p	CQLGQRIyQyIQSRF
Y321-p	LGQRIyQyIQSRFYR
S324	RIyQyIQSRFYRSPE
K453	VADYLKFKDLILRML
S529	SNSGRARSDPTHQHR
S538	PTHQHRHSGGHFAAA
S555	AMDCETHSPQVRQQF
Y705	MDVNLTVYSNPRQET
S706	DVNLTVYSNPRQETG
S748	QGADREESPMTGVCV
S758	TGVCVQQSPVASS__

	rabbit
-	gap
P13	DQQVSALPYSDQIQQ
-	gap
-	gap
-	gap
-	gap
-	gap
Y41	QRRWMDRYEIDSLIG
Y76	RHDTEMKYYIVHLKI
-	gap
-	gap
-	gap
K144	GGPGGRFKDLILRML
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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