Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SCD (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SCD Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Belongs to the fatty acid desaturase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Membrane protein, integral; Lipid Metabolism - unsaturated fatty acid biosynthesis; EC 1.14.19.1; Endoplasmic reticulum
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: iron ion binding; stearoyl-CoA 9-desaturase activity
Biological Process: fatty acid biosynthetic process
Reference #:  O00767 (UniProtKB)
Alt. Names/Synonyms: ACOD; Acyl-CoA desaturase; Delta(9)-desaturase; delta-9-desaturase; FADS5; Fatty acid desaturase; MSTP008; predicted protein of HQ0998; SCD; SCD1; SCDOS; Stearoyl-CoA desaturase; stearoyl-CoA desaturase (delta-9-desaturase); stearoyl-CoA desaturase opposite strand
Gene Symbols: SCD
Molecular weight: 41,523 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SCD
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 Y14-p QDDISSSyTTTTTIT
0 3 K34-u VLQNGGDkLETMPLy
0 1 E36 QNGGDkLETMPLyLE
0 2 Y41-p kLETMPLyLEDDIRP
0 2 K51-u DDIRPDIkDDIyDPT
0 6 Y55-p PDIkDDIyDPTykDk
0 2 Y59-p DDIyDPTykDkEGPS
0 3 K60-u DIyDPTykDkEGPSP
0 2 K62-u yDPTykDkEGPSPkV
0 2 K68-u DkEGPSPkVEYVWRN
0 1 S80-p WRNIILMsLLHLGAL
0 2 T91-p LGALYGItLIPtCKF
0 2 T95-p YGItLIPtCKFYTWL
0 26 K162-u RDHRAHHkFSETHAD
0 1 K189-u VGWLLVRkHPAVKEk
0 1 K196 kHPAVKEKGstLDLs
0 10 K196-u kHPAVKEkGstLDLs
0 2 S198-p PAVKEkGstLDLsDL
0 2 T199-p AVKEkGstLDLsDLE
0 3 T199 AVKEkGsTLDLsDLE
0 1 S203-p kGstLDLsDLEAEkL
0 3 E206 tLDLsDLEAEkLVMF
0 11 K209-u LsDLEAEkLVMFQRR
0 3 K338-u GLAYDRKkVSkAAIL
0 13 K341-u YDRKkVSkAAILARI
0 1 T351-p ILARIKRtGDGNYkS
0 1 K357-u RtGDGNYkSG_____
  mouse

 
Y13 LQEISSSYTTTTTIT
K30-u PSGNEREkVkTVPLH
K32-u GNEREkVkTVPLHLE
H37 kVkTVPLHLEEDIRP
K47-u EDIRPEMkEDIHDPT
H51 PEMkEDIHDPTYQDE
Y55 EDIHDPTYQDEEGPP
Q56 DIHDPTYQDEEGPPP
E58 HDPTYQDEEGPPPkL
K64-u DEEGPPPkLEYVWRN
V76 WRNIILMVLLHLGGL
I87 LGGLYGIILVPSCKL
S91 YGIILVPSCKLYTCL
K158-u RDHRAHHkFSETHAD
K185 VGWLLVRKHPAVKEk
K192-a KHPAVKEkGGkLDMS
K192 KHPAVKEKGGkLDMS
G194 PAVKEkGGkLDMSDL
K195 AVKEkGGKLDMSDLk
K195-u AVKEkGGkLDMSDLk
S199 kGGkLDMSDLkAEkL
K202-u kLDMSDLkAEkLVMF
K205-u MSDLkAEkLVMFQRR
K334-u GLAYDRKkVSkATVL
K337-u YDRKkVSkATVLARI
T347 VLARIKRTGDGSHKS
K353 RTGDGSHKSS_____
  rat

 
Y13 LQEISSSYTTTTTIT
K33 NLQNGREKMKKVPLY
K35 QNGREKMKKVPLYLE
Y40 KMKKVPLYLEEDIRP
R50 EDIRPEMREDIHDPS
H54 PEMREDIHDPSYQDE
Y58 EDIHDPSYQDEEGPP
Q59 DIHDPSYQDEEGPPP
E61 HDPSYQDEEGPPPKL
K67 DEEGPPPKLEYVWRN
A79 WRNIILMALLHVGAL
T90 VGALYGITLIPSSKV
S94 YGITLIPSSKVYTLL
K161-u RDHRAHHkFSETHAD
K188 VGWLLVRKHPAVKEK
K195 KHPAVKEKGGKLDMS
K195 KHPAVKEKGGKLDMS
G197 PAVKEKGGKLDMSDL
K198 AVKEKGGKLDMSDLK
K198 AVKEKGGKLDMSDLK
S202 KGGKLDMSDLKAEKL
K205 KLDMSDLKAEKLVMF
K208 MSDLKAEKLVMFQRR
K337 GLAYDRKKVSKAAVL
K340 YDRKKVSKAAVLARI
T350 VLARIKRTGDGSHKS
K356 RTGDGSHKSS_____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.